INT50335

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Context Info
Confidence 0.69
First Reported 1995
Last Reported 2010
Negated 4
Speculated 2
Reported most in Body
Documents 20
Total Number 22
Disease Relevance 5.11
Pain Relevance 2.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Foxm1) embryo development (Foxm1) DNA binding (Foxm1)
transcription factor binding (Foxm1) cytoplasm (Foxm1)
Anatomy Link Frequency
endocrine cell 2
pancreas 1
striatum 1
lungs 1
appendix 1
Foxm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid receptor 19 100.00 Very High Very High Very High
Serotonin 15 98.60 Very High Very High Very High
Cannabinoid 52 97.44 Very High Very High Very High
Inflammation 96 93.72 High High
Morphine 11 93.40 High High
narcan 3 93.16 High High
agonist 29 92.64 High High
antagonist 13 91.80 High High
Substantia nigra 2 86.16 High High
opioid receptor 1 84.96 Quite High
Disease Link Frequency Relevance Heat
Lung Cancer 93 100.00 Very High Very High Very High
Disease 18 99.90 Very High Very High Very High
Cancer 128 98.84 Very High Very High Very High
Hyperplasia 38 98.20 Very High Very High Very High
Hyperglycemia 24 96.36 Very High Very High Very High
INFLAMMATION 93 93.72 High High
Malignant Neoplastic Disease 18 89.48 High High
Diabetes Mellitus 72 86.44 High High
Hypertrophy 12 84.96 Quite High
Injury 76 81.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, Foxm1 upregulation corresponded with the peak of ?
Positive_regulation (upregulation) of Foxm1
1) Confidence 0.69 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.05 Pain Relevance 0
-cells does not require FoxM1, but these cells later switch to a FoxM1-dependent state.
Neg (not) Positive_regulation (require) of FoxM1
2) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0 Pain Relevance 0
Here, we show that Foxm1 and some of its transcriptional targets were upregulated within islets following PPx during the period of peak regeneration and that endocrine cell proliferation and regeneration of ?
Positive_regulation (upregulated) of Foxm1 in endocrine cell
3) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.25 Pain Relevance 0
These data suggest that another pathway(s), which may mimic that utilized during embryonic pancreas development, compensates for loss of FoxM1 during regeneration, as FoxM1 was also not required for embryonic ?
Neg (not) Positive_regulation (required) of FoxM1 in pancreas
4) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.34 Pain Relevance 0
S3A and B), revealing that FoxM1 is specifically required for endocrine cell proliferation.


Positive_regulation (required) of FoxM1 in endocrine cell
5) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.08 Pain Relevance 0
Sixty percent PPx upregulated Foxm1 and select targets within islets while maintaining normoglycemia.
Positive_regulation (upregulated) of Foxm1
6) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0 Pain Relevance 0
-Cells similarly required FoxM1 for PPx-stimulated proliferation (Fig. 5K).
Positive_regulation (required) of FoxM1
7) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.06 Pain Relevance 0
Elevated FOXM1 levels have been found in numerous human tumors [44-46], suggesting that FOXM1 is required for cellular proliferation in human cancer cells.
Positive_regulation (Elevated) of FOXM1 associated with cancer and hyperplasia
8) Confidence 0.49 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 0.52 Pain Relevance 0
Among these, Cdk1 is the main kinase player during G2/M transition [39] which controls execution of a transcriptional program required for mitosis through phosphorylation of Plk1 and Aurora B and subsequent activation of FoxM1, a key transcription factor during G2/M transition [35], [40].
Positive_regulation (activation) of FoxM1
9) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0 Pain Relevance 0
In addition, the activation of cannabinoid receptors with WIN 55,212-2 increased [35S]GTP gamma S binding in most of the structures examined.
Positive_regulation (activation) of WIN associated with cannabinoid receptor
10) Confidence 0.45 Published 1998 Journal Drug Alcohol Depend Section Abstract Doc Link 9649978 Disease Relevance 0.08 Pain Relevance 1.23
-cell proliferation did not require FoxM1 (online appendix Fig.
Neg (not) Positive_regulation (require) of FoxM1 in appendix
11) Confidence 0.43 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0 Pain Relevance 0
Sham-operated FoxM1?
Positive_regulation (operated) of FoxM1
12) Confidence 0.43 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.08 Pain Relevance 0
-cell regeneration, we performed 60% partial pancreatectomy (PPx) on adult female FoxM1?
Spec (partial) Positive_regulation (pancreatectomy) of FoxM1
13) Confidence 0.43 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.26 Pain Relevance 0
-cells seemingly exhibit a stronger requirement for FoxM1 than new ?
Positive_regulation (requirement) of FoxM1
14) Confidence 0.43 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.27 Pain Relevance 0
-cell neogenesis does not require FoxM1.
Neg (not) Positive_regulation (require) of FoxM1
15) Confidence 0.43 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0 Pain Relevance 0
Consistent with the induction of proliferation observed by immunohistochemistry (Fig. 3), transcripts for genes that promote cell cycle progression, including Foxm1, cyclin A2, cyclin B1, cyclin D1, and cyclin E1, were increased in lungs of CCSPrtTA/tetO-Sox17 mice after 3 days of Dox treatment (Fig. 5).
Positive_regulation (increased) of Foxm1 in lungs
16) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
This therapeutic effect is interesting because those who suffer from such disease can consume MPM during crisis and will benefit of its effect.
Positive_regulation (consume) of MPM associated with disease
17) Confidence 0.36 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1845142 Disease Relevance 1.04 Pain Relevance 0.42
Spiroperidol (a D2 receptor blocker), (+)-SCH 23390 (a D1 receptor blocker), or prior 6-OHDA lesions of the striatum blocked Win 55212-2- and CP 55940-induced turning, thus suggesting the involvement of DA transmission in cannabinoid-induced turning.
Positive_regulation (55940-induced) of Win in striatum associated with cannabinoid
18) Confidence 0.35 Published 1995 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 7617730 Disease Relevance 0 Pain Relevance 0.38
On the other hand, WIN 55212-2-induced CPP was reinstated by priming injections of MDMA, although WIN did not reinstate the MDMA-induced CPP.


Positive_regulation (induced) of WIN
19) Confidence 0.35 Published 2010 Journal Behav Brain Funct Section Abstract Doc Link PMC2858089 Disease Relevance 0.08 Pain Relevance 0.37
In our analysis, the FOXM1 gene was found up-regulated in skin from K14E6 as compared to nontransgenic mice, but we did not find significant modulation of Forkhead box family in cervix from K14E6 mice.
Positive_regulation (regulated) of FOXM1 gene in cervix
20) Confidence 0.33 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 0.57 Pain Relevance 0

General Comments

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