INT5034

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Context Info
Confidence 0.55
First Reported 1981
Last Reported 2010
Negated 6
Speculated 0
Reported most in Abstract
Documents 100
Total Number 100
Disease Relevance 28.08
Pain Relevance 54.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Insr) endosome (Insr) plasma membrane (Insr)
nucleus (Insr)
Anatomy Link Frequency
lobe 10
plasma 8
pituitary 7
hypothalamus 6
neurons 6
Insr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 148 100.00 Very High Very High Very High
Morphine 59 100.00 Very High Very High Very High
mu opioid receptor 36 100.00 Very High Very High Very High
substance P 20 100.00 Very High Very High Very High
Calcitonin gene-related peptide 11 100.00 Very High Very High Very High
Somatostatin 5 100.00 Very High Very High Very High
antagonist 38 99.98 Very High Very High Very High
Enkephalin 48 99.96 Very High Very High Very High
cocaine 14 99.80 Very High Very High Very High
narcan 88 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypertension 9 100.00 Very High Very High Very High
Diabetes Mellitus 199 99.84 Very High Very High Very High
Stress 44 99.82 Very High Very High Very High
Pain 20 99.66 Very High Very High Very High
Increased Venous Pressure Under Development 7 99.64 Very High Very High Very High
Impaired Glucose Tolerance 8 99.52 Very High Very High Very High
Cancer 10 99.18 Very High Very High Very High
Hemorrhage 8 99.12 Very High Very High Very High
Pancreatitis 4 99.10 Very High Very High Very High
Anorexia 5 99.06 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dyn A-IR, but not LE-IR, was also significantly depleted in some forebrain nuclei in all experimental groups as compared with intact controls, whereas Dyn A-IR in the hypothalamic ventromedial nucleus was elevated only in the sham-control rats.
Negative_regulation (depleted) of LE-IR in nucleus
1) Confidence 0.55 Published 1985 Journal Am. J. Physiol. Section Abstract Doc Link 2863984 Disease Relevance 0.46 Pain Relevance 0.28
Acute morphine administration (10 mg/kg) did not affect levels of ir-beta EP in any tissue, baseline or post-stress; however, naloxone (10 mg/kg) consistently and significantly prevented the reduction in N-IL ir-beta EP otherwise found following prolonged stress.
Negative_regulation (reduction) of N-IL ir-beta EP in N-IL associated with stress, narcan and morphine
2) Confidence 0.53 Published 1983 Journal Neuroendocrinology Section Abstract Doc Link 6300719 Disease Relevance 0.71 Pain Relevance 0.57
Catecholamine neurotoxin, 6-hydroxydopamine, abolished the 5-HT-IR and dramatically reduced the TH-IR in the intermediate lobe nerve fibers.
Negative_regulation (reduced) of TH-IR in lobe associated with catecholamine
3) Confidence 0.50 Published 1995 Journal Brain Res. Section Abstract Doc Link 7712183 Disease Relevance 0 Pain Relevance 0.64
At 24 h after hemorrhage, the neurointermediate lobe (NIL) showed a reduction in Dyn A-IR (52%) and AVP-IR (32%) and an increase in LE-IR (72%); at this time, the anterior lobe also showed decreased Dyn A-IR (50%) and increased LE-IR (210%).
Negative_regulation (decreased) of A-IR in lobe associated with cva
4) Confidence 0.48 Published 1985 Journal Am. J. Physiol. Section Abstract Doc Link 2863984 Disease Relevance 0.45 Pain Relevance 0.28
Treatment with a D(4) R antagonist (L745,870, 1mg/kg) blocked downregulation of MOR IR, showing that the D(4) R agonist effects observed were specific.
Negative_regulation (downregulation) of IR associated with antagonist, agonist and mu opioid receptor
5) Confidence 0.43 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17366605 Disease Relevance 0.08 Pain Relevance 1.14
Ten days after VGX, the density of CGRP-IR or Sub.P-IR fibers in the mucosa was largely reduced, while no reduction of CGRP-IR and Sub.P-IR fibers was seen in submucosal and muscular layers.
Neg (no) Negative_regulation (reduction) of Sub.P-IR associated with calcitonin gene-related peptide
6) Confidence 0.42 Published 1997 Journal Dig. Dis. Sci. Section Abstract Doc Link 9201090 Disease Relevance 0 Pain Relevance 0.65
Insulin resistance in rats induced by excess fructose was associated with the impaired insulin receptor (IR), tyrosine autophosphorylation, and insulin receptor substrate (IRS)-1 protein content in addition to the significant decrease in IRS-1 tyrosine phosphorylation in soleus muscle.
Negative_regulation (impaired) of IR in muscle associated with insulin resistance
7) Confidence 0.41 Published 2004 Journal Horm. Metab. Res. Section Abstract Doc Link 15326568 Disease Relevance 0.46 Pain Relevance 0.22
Insulin resistance in rats induced by excess fructose was associated with the impaired insulin receptor (IR), tyrosine autophosphorylation, and insulin receptor substrate (IRS)-1 protein content in addition to the significant decrease in IRS-1 tyrosine phosphorylation in soleus muscle.
Negative_regulation (impaired) of insulin receptor in muscle associated with insulin resistance
8) Confidence 0.41 Published 2004 Journal Horm. Metab. Res. Section Abstract Doc Link 15326568 Disease Relevance 0.46 Pain Relevance 0.22
When rats were fed from 17:00 to 20:00 hr, plasma IR-beta-end increased and neurohypophysial IR-beta-end and IR-Met-enk decreased at 16:00 hr, one hour before feeding.
Negative_regulation (decreased) of neurohypophysial IR-beta-end in plasma
9) Confidence 0.40 Published 1986 Journal Physiol. Behav. Section Abstract Doc Link 3018810 Disease Relevance 0 Pain Relevance 0.22
Osmopump delivery prevented the decline of NGFR-TrkA, insulin receptor (P < 0.05), and IGF-IR (P < 0.005) expressions in DRGs and improved NGF content (P < 0.05) in sciatic nerve.
Negative_regulation (decline) of insulin receptor in sciatic nerve associated with nerve growth factor and sciatic nerve
10) Confidence 0.39 Published 2006 Journal Diabetes Section Abstract Doc Link 17130507 Disease Relevance 1.36 Pain Relevance 0.46
Osmopump delivery prevented the decline of NGFR-TrkA, insulin receptor (P < 0.05), and IGF-IR (P < 0.005) expressions in DRGs and improved NGF content (P < 0.05) in sciatic nerve.
Negative_regulation (decline) of IGF-IR in sciatic nerve associated with nerve growth factor and sciatic nerve
11) Confidence 0.39 Published 2006 Journal Diabetes Section Abstract Doc Link 17130507 Disease Relevance 1.37 Pain Relevance 0.46
In contrast, the stress-induced reduction found in N-IL ir-beta EP was influenced neither by acute nor chronic treatment with dexamethasone or deoxycorticosterone.
Negative_regulation (reduction) of N-IL ir-beta EP in N-IL associated with stress and dexamethasone
12) Confidence 0.38 Published 1983 Journal Neuroendocrinology Section Abstract Doc Link 6300719 Disease Relevance 0.65 Pain Relevance 0.67
Plasma levels of immunoreactive beta-endorphin (IR-BE) were significantly reduced in STZ-induced diabetic female rats, as were the content and concentration of IR-BE in the neurointermediate lobe of the pituitary (NIL) and the content of IR-BE in the hypothalamus.
Negative_regulation (reduced) of IR-BE in Plasma associated with diabetes mellitus
13) Confidence 0.38 Published 1986 Journal Diabetes Section Abstract Doc Link 2945745 Disease Relevance 0.58 Pain Relevance 0.25
Rats sustaining VB lesions displayed a parallel depletion in neurointermediate, but not anterior, lobe levels of immunoreactive-(ir-dynorphin (DYN), ir-DYN, ir-alpha-neo-endorphin (ir-alpha-NE) and ir-vasopressin (ir-VP) whereas those of ir-Met-enkephalin (ir-ME) were unaffected.
Negative_regulation (depletion) of ir-alpha-neo-endorphin in lobe associated with dynorphin and enkephalin
14) Confidence 0.37 Published 1984 Journal Brain Res. Section Abstract Doc Link 6144361 Disease Relevance 0.06 Pain Relevance 1.04
Rats sustaining VB lesions displayed a parallel depletion in neurointermediate, but not anterior, lobe levels of immunoreactive-(ir-dynorphin (DYN), ir-DYN, ir-alpha-neo-endorphin (ir-alpha-NE) and ir-vasopressin (ir-VP) whereas those of ir-Met-enkephalin (ir-ME) were unaffected.
Neg (unaffected) Negative_regulation (unaffected) of ir-ME in lobe associated with dynorphin and enkephalin
15) Confidence 0.37 Published 1984 Journal Brain Res. Section Abstract Doc Link 6144361 Disease Relevance 0.07 Pain Relevance 1.12
Rats that had intravenously self-administrated heroin for 5 consecutive daily sessions of 6 h, and were decapitated immediately after the last session, showed a decreased concentration of beta E-IR in the anterior lobe (AL) of the pituitary while rats that had taken cocaine showed a decreased concentration of beta E-IR in the septum.
Negative_regulation (decreased) of beta E-IR in pituitary associated with cocaine
16) Confidence 0.36 Published 1989 Journal Life Sci. Section Abstract Doc Link 2523016 Disease Relevance 0.21 Pain Relevance 0.56
Rats that had intravenously self-administrated heroin for 5 consecutive daily sessions of 6 h, and were decapitated immediately after the last session, showed a decreased concentration of beta E-IR in the anterior lobe (AL) of the pituitary while rats that had taken cocaine showed a decreased concentration of beta E-IR in the septum.
Negative_regulation (decreased) of beta E-IR in pituitary associated with cocaine
17) Confidence 0.36 Published 1989 Journal Life Sci. Section Abstract Doc Link 2523016 Disease Relevance 0.14 Pain Relevance 0.48
The reduction of Fos-IR neurons by morphine pretreatment suggests that the appearance of Fos-IR neurons in the PBN may be partly due to the noxious stimulation and/or stress arising from tooth movement.
Negative_regulation (reduction) of Fos-IR in PBN associated with stress and morphine
18) Confidence 0.36 Published 2001 Journal Brain Res. Section Abstract Doc Link 11454327 Disease Relevance 0.09 Pain Relevance 0.28
In contrast, low pain threshold correlated with decreased IR-SP and IR-ME.
Negative_regulation (decreased) of IR-ME associated with pain threshold and substance p
19) Confidence 0.36 Published 1985 Journal Peptides Section Abstract Doc Link 2413427 Disease Relevance 0.50 Pain Relevance 1.39
In contrast, low pain threshold correlated with decreased IR-SP and IR-ME.
Negative_regulation (decreased) of IR-SP associated with pain threshold and substance p
20) Confidence 0.36 Published 1985 Journal Peptides Section Abstract Doc Link 2413427 Disease Relevance 0.50 Pain Relevance 1.38

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