INT50387

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Context Info
Confidence 0.45
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 67
Total Number 67
Disease Relevance 26.31
Pain Relevance 6.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (AR) transport (AR) enzyme binding (AR)
DNA binding (AR) cell-cell signaling (AR) cytoplasm (AR)
Anatomy Link Frequency
Caco-2 4
nucleus 2
plasma 1
SH-SY5Y 1
erythrocytes 1
AR (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 154 100.00 Very High Very High Very High
Potency 113 100.00 Very High Very High Very High
agonist 360 99.88 Very High Very High Very High
withdrawal 37 99.84 Very High Very High Very High
Acupuncture 221 99.80 Very High Very High Very High
beta blocker 4 99.50 Very High Very High Very High
medulla 21 99.48 Very High Very High Very High
Morphine 3 99.30 Very High Very High Very High
addiction 8 98.94 Very High Very High Very High
tolerance 11 98.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rhinitis 129 100.00 Very High Very High Very High
Reprotox - General 2 101 100.00 Very High Very High Very High
Graft Vs Host Disease 26 100.00 Very High Very High Very High
Colon Cancer 27 99.92 Very High Very High Very High
Cancer 1063 99.84 Very High Very High Very High
Prostate Cancer 578 99.14 Very High Very High Very High
Reprotox - General 1 260 98.90 Very High Very High Very High
Apoptosis 226 98.84 Very High Very High Very High
Bladder Cancer 92 98.72 Very High Very High Very High
Myeloid Leukemia 2 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In C4-2 cells, the AR protein level was markedly reduced 2 days after transfection (Figure 3A, grey box plots).
Negative_regulation (reduced) of AR
1) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994591 Disease Relevance 0.49 Pain Relevance 0
Androgen withdrawal and/or AR blockade is the main choice of treatment of nonorgan-confined prostate cancer.
Negative_regulation (blockade) of AR associated with prostate cancer and withdrawal
2) Confidence 0.43 Published 2001 Journal Eur. Urol. Section Abstract Doc Link 11684838 Disease Relevance 0.71 Pain Relevance 0.14
Transcriptional activity of the androgen receptor, which was inhibited in the presence of bicalutamide, was then turned on.


Negative_regulation (inhibited) of androgen receptor
3) Confidence 0.42 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2615041 Disease Relevance 0.29 Pain Relevance 0.24
Cell cycle analysis suggests that inhibition of AR prevents growth factor-induced proliferation of Caco-2 cells at S phase.
Negative_regulation (inhibition) of AR in Caco-2
4) Confidence 0.40 Published 2006 Journal Cancer Res. Section Abstract Doc Link 17018629 Disease Relevance 0.30 Pain Relevance 0.21
Collectively, these observations suggest that AR is an obligatory mediator of growth factor-induced up-regulation of COX-2, PGE(2), and growth of Caco-2 cells, indicating that inhibition of AR may be a novel therapeutic approach in preventing the progression of colon cancer.
Negative_regulation (inhibition) of AR in Caco-2 associated with colon cancer
5) Confidence 0.40 Published 2006 Journal Cancer Res. Section Abstract Doc Link 17018629 Disease Relevance 0.36 Pain Relevance 0.09
Inhibition of AR prevented growth factor-induced COX-2 activity, protein, and mRNA and significantly decreased activation of nuclear factor-kappaB and protein kinase C (PKC) and phosphorylation of PKC-beta2 as well as progression of Caco-2 cell growth but had no effect on COX-1 activity.
Negative_regulation (Inhibition) of AR in Caco-2 associated with kinase c
6) Confidence 0.40 Published 2006 Journal Cancer Res. Section Abstract Doc Link 17018629 Disease Relevance 0.34 Pain Relevance 0.22
Inhibition of AR prevented HNE- or GS-HNE-induced but not GS-DHN-induced up-regulation of COX-2 and PGE(2).
Negative_regulation (Inhibition) of AR
7) Confidence 0.40 Published 2006 Journal Cancer Res. Section Abstract Doc Link 17018629 Disease Relevance 0.41 Pain Relevance 0.17
The effect of OCM on transcriptional activity of the AR was inhibited by an antiandrogen.
Negative_regulation (inhibited) of AR
8) Confidence 0.39 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15014041 Disease Relevance 0.06 Pain Relevance 0
Inhibition of aldose reductase (AR; EC. 1.1.1.21.) by sorbinil or by antisense ablation prevented fibroblast growth factor-induced and platelet-derived growth factor-induced up-regulation of PGE(2) synthesis in human colon cancer cells, Caco-2.
Negative_regulation (Inhibition) of AR in Caco-2 associated with colon cancer
9) Confidence 0.35 Published 2006 Journal Cancer Res. Section Abstract Doc Link 17018629 Disease Relevance 0.37 Pain Relevance 0.19
Despite the relative increase in basal AC activity due to the development of tolerance/dependence, chronic morphine treatment was found to completely abolish spontaneous beta(2)-AR activity by reducing basal receptor/G protein precoupling.
Negative_regulation (abolish) of AR associated with addiction, tolerance and morphine
10) Confidence 0.34 Published 2000 Journal FEBS Lett. Section Abstract Doc Link 11094159 Disease Relevance 0.31 Pain Relevance 0.73
Three mutations (R779A, R779Q and R779S) of the human AR were tested for trans-activation in COS cells and were found to lead to complete inactivation of AR [21].
Negative_regulation (inactivation) of AR
11) Confidence 0.34 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1192819 Disease Relevance 0 Pain Relevance 0
At that time, the Prostate Specific Antigen (PSA) mRNA was strongly repressed in the hAR-siRNA and in the bicalutamide groups, while AR mRNA level was repressed only in the hAR-siRNA treated tumors (Figure 1F).


Negative_regulation (repressed) of AR mRNA associated with cancer
12) Confidence 0.33 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994591 Disease Relevance 0.76 Pain Relevance 0.04
All together, these data demonstrate that the inhibition of AR signaling outside the tumor does not participate in the antitumoral effect, opening promising perspectives for developing tumor-specific treatments with reduced side effects for patients.
Negative_regulation (inhibition) of AR associated with cancer
13) Confidence 0.33 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994591 Disease Relevance 1.02 Pain Relevance 0.05
AR-siRNA directed inhibition of CRCaP growth
Negative_regulation (inhibition) of AR-siRNA
14) Confidence 0.33 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994591 Disease Relevance 0.75 Pain Relevance 0
Specificity of the AR-siRNA induced inhibition of tumor growth
Negative_regulation (inhibition) of AR-siRNA associated with cancer
15) Confidence 0.33 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994591 Disease Relevance 0.72 Pain Relevance 0.04
In 22RV1 cells, the AR-siRNA effect appeared less pronounced: the AR protein level was unaffected until day 3 and the proliferation was reduced only after day 4.
Neg (unaffected) Negative_regulation (unaffected) of AR in 22RV1
16) Confidence 0.33 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994591 Disease Relevance 0.37 Pain Relevance 0
They inhibit the androgen-stimulated translocation of the AR from the cytosol to the nucleus, decrease the AR protein level in part through increased proteasomal degradation, and suppress AR transactivation activity [26,27].
Negative_regulation (decrease) of AR in nucleus
17) Confidence 0.33 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.54 Pain Relevance 0.12
The distinct effect of capsaicin-induced apoptosis on the expression pattern of HepG2 proteins includes the downregulation of some antioxidant enzymes including aldose reductase (AR), catalase, enolase 1, peroxiredoxin 1, but upregulation of peroxiredoxin 6, cytochrome c oxidase, and SOD2.
Negative_regulation (downregulation) of AR associated with qutenza and apoptosis
18) Confidence 0.32 Published 2008 Journal Proteomics Section Abstract Doc Link 18991268 Disease Relevance 0.73 Pain Relevance 0.58
Since the AR pathway is also involved in processes of cellular differentiation and prostate maturation, it is tempting to suggest that PCa cells may eventually gain growth advantage by inhibiting the AR induced differentiation.
Negative_regulation (inhibiting) of AR associated with prostate cancer
19) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.71 Pain Relevance 0
The present study further substantiates this hypothesis by showing a strong down-regulation of AR target genes compared to the parental PC346C (Fig. 2).
Negative_regulation (regulation) of AR
20) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.14 Pain Relevance 0

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