INT50392

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Context Info
Confidence 0.54
First Reported 1995
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 3.51
Pain Relevance 2.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Ret)
Anatomy Link Frequency
embryos 2
hippocampus 1
Ret (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 7 99.54 Very High Very High Very High
Analgesic 8 99.52 Very High Very High Very High
fluoxetine 1 99.52 Very High Very High Very High
Desipramine 1 99.22 Very High Very High Very High
Neuropeptide 1 98.72 Very High Very High Very High
antidepressant 2 98.30 Very High Very High Very High
Hippocampus 2 98.08 Very High Very High Very High
substance P 1 97.60 Very High Very High Very High
Calcitonin gene-related peptide 1 97.00 Very High Very High Very High
Lasting pain 1 94.00 High High
Disease Link Frequency Relevance Heat
Gestational Diabetes 18 99.84 Very High Very High Very High
Injury 46 98.94 Very High Very High Very High
Diabetes Mellitus 100 98.64 Very High Very High Very High
Pain 2 94.00 High High
Ganglion Cysts 3 93.00 High High
Apoptosis 67 92.92 High High
Convulsion 11 92.32 High High
Spinal Cord Injury 42 89.20 High High
Neuropathic Pain 3 78.32 Quite High
Optic Nerve Injuries 2 76.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whereas the Ret gene was unaltered by maternal diabetes, we found a diabetes-induced decrease in the Shh mRNA levels in the MD embryos.
Regulation (unaltered) of Ret in embryos associated with diabetes mellitus and gestational diabetes
1) Confidence 0.54 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.55 Pain Relevance 0.03
Reduction of NCAM expression by NCAM antisense oligodeoxynucleotide administration to CCI rats abolished the analgesic effect of GDNF without affecting RET signaling activation.
Neg (without) Regulation (affecting) of RET associated with analgesic and injury
2) Confidence 0.38 Published 2008 Journal Pain Section Abstract Doc Link 17967506 Disease Relevance 0.97 Pain Relevance 1.00
Chronic (14 days) administration of different classes of antidepressant drugs, including tranylcypromine, desipramine, or fluoxetine, did not significantly affect the GDNF, GFRalpha-1, GFRalpha-2, or RET mRNA levels in CA1, CA3, and dentate gyrus areas of hippocampus.
Neg (not) Regulation (affect) of RET mRNA in hippocampus associated with desipramine, antidepressant, hippocampus and fluoxetine
3) Confidence 0.22 Published 2001 Journal Synapse Section Abstract Doc Link 11071708 Disease Relevance 0.82 Pain Relevance 0.30
Shh was decreased, Ret was unaltered, and Bmp-4 mRNA levels were increased in MD embryos compared with N embryos (Fig. 4).
Regulation (unaltered) of Ret in embryos
4) Confidence 0.21 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.36 Pain Relevance 0
We found the simultaneous up-regulation of both co-receptor genes for the neurotrophic factor GDNF (Gfra1 and Ret).
Regulation (regulation) of Ret
5) Confidence 0.16 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2894843 Disease Relevance 0.81 Pain Relevance 0.05
Colocalization of enkephalin immunoreactivity with immunoreactivities for tyrosin hydroxylase, dopamin-beta-hydroxylase, and neuropeptide Y, but not for substance P or calcitonin gene-related peptide were found.
Neg (not) Regulation (immunoreactivities) of tyrosin hydroxylase associated with neuropeptide, enkephalin, calcitonin gene-related peptide and substance p
6) Confidence 0.00 Published 1995 Journal Cell Tissue Res. Section Abstract Doc Link 7621519 Disease Relevance 0 Pain Relevance 0.83

General Comments

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