INT504

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Context Info
Confidence 0.75
First Reported 1979
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 42
Total Number 43
Disease Relevance 27.54
Pain Relevance 3.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GPT) small molecule metabolic process (GPT) biosynthetic process (GPT)
cellular nitrogen compound metabolic process (GPT) cytoplasm (GPT)
Anatomy Link Frequency
liver 12
blood 4
kidney 4
upper 2
hepatocytes 1
GPT (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 1 100.00 Very High Very High Very High
abdominal pain 13 99.58 Very High Very High Very High
agonist 129 99.52 Very High Very High Very High
analgesia 2 99.12 Very High Very High Very High
epidural 2 98.92 Very High Very High Very High
Pain 26 98.74 Very High Very High Very High
ketamine 5 98.24 Very High Very High Very High
halothane 1 97.52 Very High Very High Very High
anesthesia 15 97.46 Very High Very High Very High
headache 13 91.16 High High
Disease Link Frequency Relevance Heat
Fever 58 100.00 Very High Very High Very High
Jaundice 6 100.00 Very High Very High Very High
Hepatitis C Virus Infection 85 99.92 Very High Very High Very High
Congenital Anomalies 17 99.92 Very High Very High Very High
Abdominal Pain 13 99.58 Very High Very High Very High
Disorders Of Creatine Metabolism 14 99.40 Very High Very High Very High
Hepatotoxicity 14 99.36 Very High Very High Very High
Death 46 99.04 Very High Very High Very High
Pain 18 98.74 Very High Very High Very High
Disease 133 98.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The influence of four different types of anaesthesia -- halothane and enflurane inhalation anaestheis, neurolept analgesia and epidural analgesia with single shot technique -- on the serum levels of GOT, GPT, GLDH, LDH, AP, LAP, gamma-GT, total protein and bilirubin was examined in 104 comparable cases undergoing gynaecological surgery.
Gene_expression (levels) of GPT associated with epidural, halothane and analgesia
1) Confidence 0.75 Published 1979 Journal Prakt Anaesth Section Abstract Doc Link 42895 Disease Relevance 0 Pain Relevance 0.30
The principal problem with bosentan is hepatotoxicity initially manifest as elevated levels of alanine aminotransferase and aspartate aminotransferase.
Gene_expression (levels) of alanine aminotransferase associated with hepatotoxicity
2) Confidence 0.75 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2725793 Disease Relevance 0.35 Pain Relevance 0.17
To follow the liver function repeated measurements of liver aminotransferase levels such as alanine aminotransferase (ALT), aspartate aminotransferase (AST) and bilirubin levels up to 7 days after the last dose of study medication were performed.
Gene_expression (levels) of alanine aminotransferase in liver
3) Confidence 0.65 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597756 Disease Relevance 0.19 Pain Relevance 0
Inclusion criteria were age above 18 years, symptoms (fever or jaundice) lasting less than 21 days, and elevated serum alanine aminotransferase (ALT) ?
Gene_expression (age) of alanine aminotransferase associated with jaundice and fever
4) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605267 Disease Relevance 0.98 Pain Relevance 0
Complete blood count, liver function tests (AST, ALT, APH, ?
Gene_expression (function) of ALT in liver
5) Confidence 0.65 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699810 Disease Relevance 0.32 Pain Relevance 0.04
A detailed clinical examination was performed and blood samples were drawn to repeat the anti-HCV tests, serum ALT estimations, HCV RNA determinations and ultrasound liver examinations.
Spec (examinations) Gene_expression (estimations) of ALT in blood associated with hepatitis c virus infection
6) Confidence 0.65 Published 2009 Journal Virol J Section Body Doc Link PMC2806292 Disease Relevance 0.78 Pain Relevance 0
Serum alanine aminotransferase (ALT) and creatinine were tested at each vaccination and on days 3 and 14 following vaccination.
Gene_expression (tested) of ALT
7) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809736 Disease Relevance 0.97 Pain Relevance 0.18
Grade I and II toxicities were observed in four patients (2 abdominal pain, 1 fever, and 1 AST/ALT elevation).
Gene_expression (elevation) of ALT associated with abdominal pain and fever
8) Confidence 0.65 Published 2005 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2810594 Disease Relevance 0.83 Pain Relevance 0.10
Sixteen patients had elevated levels of aspartate aminotransferase or alanine aminotransferase.
Gene_expression (levels) of alanine aminotransferase
9) Confidence 0.65 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2844980 Disease Relevance 1.45 Pain Relevance 0.17
Plasma aspartate aminotransferase (AST)/alanine aminotransferase (ALT) and BUN were evaluated to reflect liver and kidney function, respectively; none of these parameters were affected by OA-NO2 treatment (AST: 156.8 ± 18.4 versus 159 ± 7.7?
Gene_expression (reflect) of alanine aminotransferase in kidney
10) Confidence 0.65 Published 2010 Journal PPAR Research Section Body Doc Link PMC2910468 Disease Relevance 0.84 Pain Relevance 0
Plasma aspartate aminotransferase (AST)/alanine aminotransferase (ALT) and BUN were evaluated to reflect liver and kidney function, respectively; none of these parameters were affected by OA-NO2 treatment (AST: 156.8 ± 18.4 versus 159 ± 7.7?
Gene_expression (/) of alanine aminotransferase in kidney
11) Confidence 0.65 Published 2010 Journal PPAR Research Section Body Doc Link PMC2910468 Disease Relevance 0.83 Pain Relevance 0
Plasma aspartate aminotransferase (AST)/alanine aminotransferase (ALT) and BUN were evaluated to reflect liver and kidney function, respectively; none of these parameters were affected by OA-NO2 treatment (AST: 156.8 ± 18.4 versus 159 ± 7.7?
Gene_expression (evaluated) of alanine aminotransferase in kidney
12) Confidence 0.65 Published 2010 Journal PPAR Research Section Body Doc Link PMC2910468 Disease Relevance 0.84 Pain Relevance 0
Hence, incipient myopathy was retrospectively defined as creatine kinase more than both three times the upper limit of normal and five times the participant's baseline value plus alanine aminotransferase more than 1·7 times their baseline value.12

Statistical analysis

Gene_expression (analysis) of alanine aminotransferase in upper associated with muscle disease
13) Confidence 0.65 Published 2010 Journal Lancet Section Body Doc Link PMC2988223 Disease Relevance 0.62 Pain Relevance 0
60 mLs/min), hepatic (alanine aminotransferase and aspartate aminotransferase ?
Gene_expression (hepatic) of alanine aminotransferase
14) Confidence 0.65 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998804 Disease Relevance 1.01 Pain Relevance 0
2.0 mg/dL, aspartate aminotransferase (AST)/alanine aminotransferase (ALT) < 3 × upper limit of normal), and kidney (serum creatinine (Crt) ?
Gene_expression (/) of alanine aminotransferase in kidney
15) Confidence 0.65 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3014873 Disease Relevance 0.41 Pain Relevance 0
Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), and ceruloplasmin levels were measured in serum samples of rats using the commercial kit, Abbott Architect C–8000 Autoanalyzer (Abbott Laboratories, USA).
Gene_expression (levels) of alanine aminotransferase
16) Confidence 0.65 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020349 Disease Relevance 0.29 Pain Relevance 0.21
Other laboratory data evaluated were total blood count, aspartate aminotransaminase (AST), and alanine aminotransaminase (ALT).
Gene_expression (count) of ALT in blood
17) Confidence 0.65 Published 2010 Journal Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine Section Body Doc Link PMC3021827 Disease Relevance 1.25 Pain Relevance 0
Also an increased in his aminotranferases enzymes was observed Alanine Aminotranseferase (ALT) 555, and Apartate Aminotransferase (ALT) 2292.
Gene_expression (observed) of ALT
18) Confidence 0.65 Published 2008 Journal Cases J Section Body Doc Link PMC2561012 Disease Relevance 0.36 Pain Relevance 0.30
100 × 109/L, and hemoglobin > 10 g/dL), hepatic function (aspartate aminotransferase/alanine aminotransferase, AST/ALT) ?
Gene_expression (/) of ALT
19) Confidence 0.65 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1906828 Disease Relevance 0.59 Pain Relevance 0
100 × 109/L), bilirubin under 1.25 times upper normal value (UNV), aspartate aminotransferase/alanine aminotransferase (AST/ALT) under 2 times UNV, and renal function (creatinine level under 120 ?
Gene_expression (/) of ALT in upper
20) Confidence 0.65 Published 2004 Journal BMC Cancer Section Body Doc Link PMC526296 Disease Relevance 1.21 Pain Relevance 0.13

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