INT5040

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 1988
Last Reported 2008
Negated 2
Speculated 4
Reported most in Abstract
Documents 42
Total Number 47
Disease Relevance 12.72
Pain Relevance 21.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Gal) Golgi apparatus (Gal) response to stress (Gal)
cytoplasm (Gal)
Anatomy Link Frequency
neurons 8
DRG 4
nucleus 2
spinal 2
lateral 2
Gal (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 62 100.00 Very High Very High Very High
Morphine 23 100.00 Very High Very High Very High
substance P 21 100.00 Very High Very High Very High
Calcitonin gene-related peptide 20 100.00 Very High Very High Very High
withdrawal 14 100.00 Very High Very High Very High
intrathecal 14 100.00 Very High Very High Very High
narcan 14 100.00 Very High Very High Very High
Enkephalin 9 100.00 Very High Very High Very High
Neurotransmitter 7 100.00 Very High Very High Very High
Dorsal horn neuron 7 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 12 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 3 99.98 Very High Very High Very High
Nervous System Injury 23 99.84 Very High Very High Very High
Ganglion Cysts 44 99.44 Very High Very High Very High
Aids-related Complex 8 99.44 Very High Very High Very High
Injury 8 99.42 Very High Very High Very High
Hyperalgesia 5 99.20 Very High Very High Very High
INFLAMMATION 11 99.16 Very High Very High Very High
Status Epilepticus 2 99.04 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

10 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Behavioral effect of galanin and its fragments, galanin1-15 and galanin16-29 (200 ng, 1 and 5 micrograms), after intracerebroventricular (i.c.v.) administration was studied in rats.
Regulation (effect) of galanin associated with intracerebroventricular
1) Confidence 0.60 Published 1995 Journal J. Neural Transm. Gen. Sect. Section Abstract Doc Link 8788071 Disease Relevance 0.07 Pain Relevance 0.36
We examined the effects of LIF on capsaicin sensitivity, heat responsiveness, and galanin immunoreactivity in rat dorsal root ganglion neurons cultured for up to 6 days without supplemented NGF.
Regulation (immunoreactivity) of galanin in neurons associated with ganglion cysts, nerve growth factor, qutenza and root ganglion neuron
2) Confidence 0.60 Published 2008 Journal Neuropeptides Section Abstract Doc Link 18258298 Disease Relevance 0.68 Pain Relevance 0.72
Although long-term adaptations of LC neurons have previously been implicated in the development of morphine tolerance, dependence, and withdrawal, alterations in the levels of TH, GAL, or NPY mRNA in the LC apparently do not underlie this process.
Regulation (alterations) of GAL in neurons associated with addiction, locus ceruleus, tolerance, withdrawal and morphine
3) Confidence 0.60 Published 1995 Journal Synapse Section Abstract Doc Link 7540319 Disease Relevance 0.05 Pain Relevance 1.53
The present results show that galanin and galanin receptors are present in sensory and local dorsal horn neurons and are regulated by nerve injury and inflammation.
Regulation (regulated) of galanin in neurons associated with nervous system injury, inflammation and dorsal horn neuron
4) Confidence 0.55 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9928186 Disease Relevance 0.91 Pain Relevance 0.98
The objective of the present study was to determine the rostrocaudal distribution and the effect of reduced food intake (60% of the average daily food intake for 1-4 weeks) on the amount of leucine-enkephalin (Leu-enk), neuropeptide Y (NPY) and galanin (Gal) in the lateral septum of male rat brain.
Regulation (effect) of Gal in lateral associated with neuropeptide and enkephalin
5) Confidence 0.45 Published 2005 Journal Acta. Biol. Hung. Section Abstract Doc Link 16196194 Disease Relevance 0 Pain Relevance 0.19
The objective of the present study was to determine the rostrocaudal distribution and the effect of reduced food intake (60% of the average daily food intake for 1-4 weeks) on the amount of leucine-enkephalin (Leu-enk), neuropeptide Y (NPY) and galanin (Gal) in the lateral septum of male rat brain.
Regulation (effect) of galanin in lateral associated with neuropeptide and enkephalin
6) Confidence 0.45 Published 2005 Journal Acta. Biol. Hung. Section Abstract Doc Link 16196194 Disease Relevance 0 Pain Relevance 0.19
To address the question of postsynaptic action, we examined the effects of IT galanin upon IT SP-induced thermal hyperalgesia and spinal PGE2 release.
Spec (examined) Regulation (effects) of galanin in spinal associated with thermal hyperalgesia, substance p and intrathecal
7) Confidence 0.44 Published 2005 Journal Neuropeptides Section Abstract Doc Link 15944014 Disease Relevance 0.24 Pain Relevance 1.09
Varicosities immunoreactive for calcitonin gene-related peptide (CGRP), vasoactive intestinal polypeptide (VIP), enkephalin (ENK), substance P (SP) and galanin (GAL) appear to be associated with principal neurons.
Regulation (immunoreactive) of GAL in neurons associated with enkephalin, increased venous pressure under development, substance p and calcitonin gene-related peptide
8) Confidence 0.44 Published 1996 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 8816365 Disease Relevance 0.95 Pain Relevance 0.54
The effects of galanin (GAL) on magnocellular neurosecretory cells (MNCs) were examined during microelectrode recordings from supraoptic neurons in superfused hypothalamic explants.
Regulation (effects) of GAL in neurosecretory cells
9) Confidence 0.44 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9236216 Disease Relevance 0 Pain Relevance 0.06
The effects of galanin (GAL) on magnocellular neurosecretory cells (MNCs) were examined during microelectrode recordings from supraoptic neurons in superfused hypothalamic explants.
Regulation (effects) of galanin in neurosecretory cells
10) Confidence 0.44 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9236216 Disease Relevance 0 Pain Relevance 0.06
The changes of preprogalanin mRNA levels in the superficial dorsal horn neurons (laminae I and II) of the trigeminal nucleus caudalis in response to orofacial pain induced by the injection of 5% formalin into the lips of rats was investigated and compared to those of preproenkephalin A mRNA and preprodynorphin mRNA in the same region by means of in situ hybridization histochemistry.
Spec (investigated) Regulation (changes) of galanin in dorsal horn associated with face pain and dorsal horn neuron
11) Confidence 0.44 Published 1992 Journal Peptides Section Abstract Doc Link 1283628 Disease Relevance 0.17 Pain Relevance 0.22
Lack of effect of chronic morphine treatment and naloxone-precipitated withdrawal on tyrosine hydroxylase, galanin, and neuropeptide Y mRNA levels in the rat locus coeruleus.
Regulation (effect) of galanin in locus coeruleus associated with locus ceruleus, neuropeptide, narcan, withdrawal and morphine
12) Confidence 0.44 Published 1995 Journal Synapse Section Title Doc Link 7540319 Disease Relevance 0.10 Pain Relevance 1.65
This suggests a possible involvement of NPY and Gal in the regulation of sympathetic nerve activity in medulla oblongata.
Spec (possible) Regulation (involvement) of Gal in nerve associated with medulla
13) Confidence 0.43 Published 1990 Journal Am. J. Hypertens. Section Abstract Doc Link 1699553 Disease Relevance 0 Pain Relevance 0.70
In addition, we show regionally specific and subtype specific regulation of galanin receptors.
Regulation (regulation) of galanin
14) Confidence 0.42 Published 2005 Journal Neuropeptides Section Abstract Doc Link 15944003 Disease Relevance 0.33 Pain Relevance 0.28
The effect of ethanol on GAL, ENK, and DYN mRNA was measured using real-time quantitative polymerase chain reaction and radiolabeled in situ hybridization, while radioimmunoassay was used to measure peptide levels.
Regulation (effect) of GAL
15) Confidence 0.41 Published 2007 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 17250616 Disease Relevance 0 Pain Relevance 0
The effects of intrathecal galanin and C-fiber stimulation on the flexor reflex in the rat.
Regulation (effects) of galanin associated with c fibre, neuropeptide and intrathecal
16) Confidence 0.39 Published 1989 Journal Brain Res. Section Title Doc Link 2471574 Disease Relevance 0.22 Pain Relevance 0.56
Changes in the magnocellular region of the hypothalamic paraventricular nucleus suggest a role for galanin neural circuits at this level in fluoxetine-induced hydro-osmotic impairment.
Regulation (role) of galanin in nucleus associated with fluoxetine
17) Confidence 0.39 Published 2004 Journal Nutr Neurosci Section Abstract Doc Link 15526991 Disease Relevance 0.48 Pain Relevance 0.50
Morphological alterations and changes in peptide [calcitonin gene-related peptide (CGRP), substance P, galanin (Gal), and somatostatin] concentration were studied in the DRG, the spinal cord, and the sciatic nerve.
Regulation (changes) of Gal in DRG associated with somatostatin, sciatic nerve, spinal cord, substance p and calcitonin gene-related peptide
18) Confidence 0.39 Published 1996 Journal Exp. Neurol. Section Abstract Doc Link 8593900 Disease Relevance 0.13 Pain Relevance 0.51
The aim of the present study was to evaluate the effects of a synthetic porcine galanin sequence, Gal(1-16), on stimulated pancreatic secretion in hyperglycemic anesthetized and conscious rats.
Regulation (effects) of galanin
19) Confidence 0.38 Published 2000 Journal Res Exp Med (Berl) Section Abstract Doc Link 10815756 Disease Relevance 0.07 Pain Relevance 0.04
Effects of galanin on the opossum internal anal sphincter: structure-activity relationship.
Regulation (Effects) of galanin in internal anal sphincter associated with neuropeptide
20) Confidence 0.38 Published 1991 Journal Gastroenterology Section Title Doc Link 1704327 Disease Relevance 0 Pain Relevance 0.21

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox