INT50410

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Context Info
Confidence 0.03
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.79
Pain Relevance 3.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Zbtb38) nucleus (Zbtb38) intracellular (Zbtb38)
DNA binding (Zbtb38)
Anatomy Link Frequency
neurons 2
sensory neurons 1
IAN 1
IB4 1
hippocampus 1
Zbtb38 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 243 100.00 Very High Very High Very High
narcan 6 99.98 Very High Very High Very High
Calcitonin gene-related peptide 288 99.80 Very High Very High Very High
inferior alveolar nerve 151 99.50 Very High Very High Very High
Hippocampus 14 98.92 Very High Very High Very High
ischemia 67 97.56 Very High Very High Very High
Peripheral nerve injury 4 96.72 Very High Very High Very High
Opioid 4 95.68 Very High Very High Very High
substance P 16 94.12 High High
Neuropeptide 35 93.44 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 288 100.00 Very High Very High Very High
Cv General 4 Under Development 59 97.56 Very High Very High Very High
Nervous System Injury 23 96.72 Very High Very High Very High
Apoptosis 11 87.20 High High
Neuropathic Pain 8 54.24 Quite High
Disease 8 53.60 Quite High
Pain 19 51.24 Quite High
Death 6 48.12 Quite Low
Cv Unclassified Under Development 6 40.84 Quite Low
Middle Cerebral Artery Infarction 3 40.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conscious 21 d pregnant rats naloxone increased the number of neurons expressing Fos (an indicator of neuronal activity) in the supraoptic nucleus (SON) but had no effect on 16 d pregnant or virgin rats.
Positive_regulation (increased) of of neurons expressing in neurons associated with narcan
1) Confidence 0.03 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7623133 Disease Relevance 0 Pain Relevance 0.68
In the case of IAN transection for example, IAN fibers show significant increases in background activity and also trigeminal ganglion (TG) neurons show a change in the expression of several types of Na+ channels [33-37].
Positive_regulation (increases) of neurons in IAN associated with ganglion cysts, inferior alveolar nerve and trigeminal ganglion
2) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829527 Disease Relevance 0.65 Pain Relevance 0.79
Furthermore, E2-induces ERK activation in the CA1 region after GCI, which is critical for its neuroprotective effects as treatment with a MEK inhibitor blocked E2-induced ERK activation and E2 neuroprotection in the hippocampus [27] Likewise, a role for the prosurvival serine kinase Akt in E2 neuroprotection has been implicated, as E2 rapidly up-regulates Akt activation in cortical neurons in vitro [28], and in the hippocampus CA1 in vivo following GCI [29], while treatment with a PI3K inhibitor attenuates the neuroprotective effects of E2 both in vitro and in vivo [28], [29].
Positive_regulation (activation) of neurons in hippocampus associated with ischemia and hippocampus
3) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.32 Pain Relevance 0.34
Because there were differences in neuron numbers between growth factor conditions, we examined under each condition the proportion of neurons that were positive for CGRP, TRPV1 or IB4.
Positive_regulation (positive) of neurons in IB4 associated with calcitonin gene-related peptide
4) Confidence 0.00 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.08 Pain Relevance 0.78
The addition of GDNF or BDNF to the culture medium here may have re-supplied, at least partially, the withdrawn glial-supplied trophic factors that maintain sensory neurons in vivo, thereby increasing the number of neurons in culture at 5 days.
Positive_regulation (increasing) of neurons in sensory neurons
5) Confidence 0.00 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.67 Pain Relevance 0.38
The proportion of neurons positive for CGRP, TRPV1 or IB4 are shown in Table 1.
Positive_regulation (positive) of neurons in neurons associated with calcitonin gene-related peptide
6) Confidence 0.00 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.07 Pain Relevance 0.81

General Comments

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