INT50419

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Context Info
Confidence 0.25
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 6.11
Pain Relevance 6.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal cord 2
spinal 1
nerve 1
striatum 1
adrenal gland 1
Grina (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 226 100.00 Very High Very High Very High
projection neuron 2 99.84 Very High Very High Very High
Spinal cord 93 99.68 Very High Very High Very High
Morphine 3 99.14 Very High Very High Very High
central sensitization 51 98.68 Very High Very High Very High
Hippocampus 23 98.52 Very High Very High Very High
Inflammation 132 97.00 Very High Very High Very High
Dorsal horn 24 96.56 Very High Very High Very High
nud 51 96.16 Very High Very High Very High
carrageenan induced 2 94.72 High High
Disease Link Frequency Relevance Heat
Colitis 25 99.36 Very High Very High Very High
Nociception 81 98.80 Very High Very High Very High
Neuropathic Pain 37 98.28 Very High Very High Very High
INFLAMMATION 134 97.00 Very High Very High Very High
Frailty 8 96.88 Very High Very High Very High
Dyspepsia 51 96.16 Very High Very High Very High
Hypersensitivity 19 92.32 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

31 91.16 High High
Pressure And Volume Under Development 4 91.08 High High
Pain 38 91.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among all GAD65-immunoreactive terminals counted, 37% express the NMDA receptor subunit NR1; 28% are immunopositive using an antibody for the GluR2/4 subunits of the AMPA receptor; and 20-35% are immunopositive using antibodies for the kainate receptor subunits GluR5, GluR6/7, KA1, or KA2.
Gene_expression (express) of NMDA receptor subunit associated with nmda receptor
1) Confidence 0.25 Published 2005 Journal J. Comp. Neurol. Section Abstract Doc Link 15844209 Disease Relevance 0.05 Pain Relevance 0.61
NMDA receptor subunit mRNA expression by projection neurons and interneurons in rat striatum.
Gene_expression (expression) of NMDA receptor subunit in striatum associated with nmda receptor and projection neuron
2) Confidence 0.24 Published 1995 Journal J. Neurosci. Section Title Doc Link 7623152 Disease Relevance 0.09 Pain Relevance 0.58
Mechanistic studies revealed that MIF upregulated the expression of the spinal NMDA receptor subunit NR2B via the MAPK signaling pathway.
Gene_expression (expression) of NMDA receptor subunit in spinal associated with nmda receptor
3) Confidence 0.24 Published 2010 Journal Pain Section Abstract Doc Link 20005040 Disease Relevance 0.53 Pain Relevance 0.60
Our approach was to compare spinal NMDA receptor subunit expression and especially subunit 1 phosphorylation, assessed with immunohistochemistry and Western blot at late postoperative times, between nerve-injured rats with marked signs of neuropathy in terms of mechanical and cold hypersensitivity and nerve-injured rats that lacked robust behavioral signs of neuropathy.
Gene_expression (expression) of NMDA receptor subunit in nerve associated with nmda receptor, hypersensitivity and neuropathic pain
4) Confidence 0.22 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16469445 Disease Relevance 0.97 Pain Relevance 0.67
Formalin-induced changes of NMDA receptor subunit expression in the spinal cord of the rat.
Gene_expression (expression) of NMDA receptor subunit in spinal cord associated with nmda receptor and spinal cord
5) Confidence 0.19 Published 2002 Journal Amino Acids Section Title Doc Link 12373534 Disease Relevance 0.09 Pain Relevance 0.43
Primers of NR1 pan, NR1-Exon 21(C1), NR1-Exon 22 (C2) and NR1-Exon 5 (N1) were used to monitor NMDA receptor subunit mRNA expression following TNBS colitis.
Gene_expression (expression) of NMDA receptor subunit mRNA associated with colitis and nmda receptor
6) Confidence 0.15 Published 2006 Journal Mol Pain Section Body Doc Link PMC1402265 Disease Relevance 0.40 Pain Relevance 0.05
However, it is unclear if extended periods of central sensitization are maintained by NMDA receptor phosphorylation or if changes in NMDA receptor subunit protein expression contribute to the continuance of the sensitized state as was observed in the spinal cord injury model [16].
Gene_expression (expression) of NMDA receptor subunit in spinal cord associated with central sensitization, nmda receptor and spinal cord
7) Confidence 0.14 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.55 Pain Relevance 0.82
The goal was to determine if there is a transition from NMDA receptor subunit phosphorylation to changes in NMDA receptor subunit protein expression during an extended period of nociceptive input and the relationship of these changes to central sensitization.


Gene_expression (expression) of NMDA receptor subunit associated with nociception, central sensitization and nmda receptor
8) Confidence 0.14 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.40 Pain Relevance 0.64
Single dose of morphine influences plasma corticosterone and gene expression of main NMDA receptor subunit in the adrenal gland but not in the hippocampus.
Gene_expression (expression) of NMDA receptor subunit in adrenal gland associated with nmda receptor, hippocampus and morphine
9) Confidence 0.14 Published 2001 Journal Endocr Regul Section Title Doc Link 11858765 Disease Relevance 0 Pain Relevance 0.42
Given that the mRNA profiles for NR1, NR2A, and NR2B subunits were not significantly altered following prolonged UCB exposure, it seems likely that UCB-induced decrease in NMDA receptor subunit expression is not due to the change in gene expression mechanisms.
Gene_expression (expression) of NMDA receptor subunit associated with nmda receptor
10) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690688 Disease Relevance 0.32 Pain Relevance 0.57
Thus, UCB-induced decrease in NMDA receptor subunit protein expression is not due to the change of gene expression profiles.
Gene_expression (expression) of NMDA receptor subunit associated with nmda receptor
11) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690688 Disease Relevance 0.26 Pain Relevance 0.37
NMDA receptor subunit expression and PAR2 receptor activation in colospinal afferent neurons (CANs) during inflammation induced visceral hypersensitivity

Background

Gene_expression (expression) of NMDA receptor subunit in afferent neurons associated with inflammation, nmda receptor and nud
12) Confidence 0.04 Published 2009 Journal Mol Pain Section Title Doc Link PMC2758842 Disease Relevance 1.06 Pain Relevance 0.62
The receptor-binding B subunit is protective antigen (PA), which is initially synthesized as an 83-kD precursor.
Gene_expression (synthesized) of receptor-binding B subunit
13) Confidence 0.01 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC2000967 Disease Relevance 1.17 Pain Relevance 0.05

General Comments

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