INT50420

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.71
First Reported 1995
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 30
Total Number 34
Disease Relevance 13.21
Pain Relevance 18.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1) enzyme binding (Grin1) cytoplasm (Grin1)
Anatomy Link Frequency
midbrain 4
spinal cord 2
striatum 2
cingulate cortex 2
hippocampus 2
Grin1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 277 100.00 Very High Very High Very High
Dorsal horn 19 99.98 Very High Very High Very High
Morphine 64 99.92 Very High Very High Very High
amygdala 19 99.92 Very High Very High Very High
Nucleus accumbens 38 99.76 Very High Very High Very High
Spinal cord 86 99.74 Very High Very High Very High
midbrain 4 99.52 Very High Very High Very High
substance P 27 99.36 Very High Very High Very High
Hippocampus 35 99.32 Very High Very High Very High
Central grey 32 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoxia 432 99.40 Very High Very High Very High
Urological Neuroanatomy 41 99.16 Very High Very High Very High
Ganglion Cysts 27 98.76 Very High Very High Very High
Dyspepsia 32 97.24 Very High Very High Very High
Injury 71 96.88 Very High Very High Very High
INFLAMMATION 116 96.36 Very High Very High Very High
Neuropathic Pain 33 95.60 Very High Very High Very High
Anxiety Disorder 6 95.36 Very High Very High Very High
Diabetic Retinopathy 12 94.40 High High
Nociception 83 94.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The density and distribution of N-methyl-D-aspartate receptor (NMDAR1) mRNA expression in the rat midbrain periaqueductal gray (PAG) following exposure to unilateral peripheral inflammation or chronic constrictive injury (CCI) as models for chronic peripheral nociception were examined using in situ hybridization technique.
Transcription (expression) of NMDAR1 in midbrain associated with nociception, inflammation, nmda receptor, injury, midbrain and central grey
1) Confidence 0.71 Published 1998 Journal Neurobiology (Bp) Section Abstract Doc Link 9778652 Disease Relevance 0.86 Pain Relevance 0.32
The density and distribution of N-methyl-D-aspartate receptor (NMDAR1) mRNA expression in the rat midbrain Periaqueductal gray (PAG) following exposure to unilateral peripheral inflammation or chronic constrictive injury (CCI) as models for chronic peripheral nociception were examined using the in situ hybridization technique.
Transcription (expression) of NMDAR1 in midbrain associated with nociception, inflammation, nmda receptor, injury, midbrain and central grey
2) Confidence 0.71 Published 1998 Journal Ir J Med Sci Section Abstract Doc Link 9780569 Disease Relevance 0.86 Pain Relevance 0.32
The acute effects of subcutaneously injected morphine on transcripts of the NMDA receptor subunits NR1, NR2A and NR2B in certain areas of the central nervous system of male rats were examined by Northern blot analysis.
Transcription (transcripts) of NR1 in central nervous system associated with nmda receptor, central nervous system and morphine
3) Confidence 0.69 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9543234 Disease Relevance 0 Pain Relevance 0.60
RESULTS: The main results are the postpubertal onset of increased NR1 mRNA expression in all cortical regions and decreased dopamine D2 receptor, substance P and enkephalin mRNA expression in the striatum only in rats lesioned as neonates.
Transcription (expression) of NR1 in striatum
4) Confidence 0.69 Published 2009 Journal Schizophr. Res. Section Body Doc Link 19500946 Disease Relevance 0 Pain Relevance 0
The density and distribution of N-methyl-D-aspartate receptor (NMDAR1) mRNA expression in the rat midbrain periaqueductal gray (PAG) following exposure to unilateral peripheral inflammation or chronic constrictive injury (CCI) as models for chronic peripheral nociception were examined using in situ hybridization technique.
Transcription (expression) of N-methyl-D-aspartate receptor in midbrain associated with nociception, inflammation, nmda receptor, injury, midbrain and central grey
5) Confidence 0.68 Published 1998 Journal Neurobiology (Bp) Section Abstract Doc Link 9778652 Disease Relevance 0.86 Pain Relevance 0.32
The density and distribution of N-methyl-D-aspartate receptor (NMDAR1) mRNA expression in the rat midbrain Periaqueductal gray (PAG) following exposure to unilateral peripheral inflammation or chronic constrictive injury (CCI) as models for chronic peripheral nociception were examined using the in situ hybridization technique.
Transcription (expression) of N-methyl-D-aspartate receptor in midbrain associated with nociception, inflammation, nmda receptor, injury, midbrain and central grey
6) Confidence 0.68 Published 1998 Journal Ir J Med Sci Section Abstract Doc Link 9780569 Disease Relevance 0.86 Pain Relevance 0.32
Parallel to the protein expression, the mRNA of NR1-N1 plus and NR1-C1 were also present at 14, 21 and 28 days after TNBS treatment.
Transcription (present) of NR1
7) Confidence 0.67 Published 2006 Journal Mol Pain Section Body Doc Link PMC1402265 Disease Relevance 0.51 Pain Relevance 0.28
Finally, repeated dosing with MTEP (2 mg/kg i.p.) caused significant reductions in expression of the mRNA encoding the NR1 subunit of the N-methyl-D-aspartate receptor and the GluR2 subunit of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor in the cingulate cortex.
Transcription (expression) of N-methyl-D-aspartate receptor in cingulate cortex associated with nmda receptor
8) Confidence 0.67 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16014750 Disease Relevance 0.76 Pain Relevance 0.53
Both populations of striatal interneurons examined express lower levels of NMDAR1 and NMDAR2B subunit mRNA than enkephalin-positive neurons.
Transcription (express) of NMDAR1 in neurons associated with enkephalin
9) Confidence 0.67 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7623152 Disease Relevance 0.08 Pain Relevance 0.70
In the genetic section, the mRNA expression of NMDA receptor subunits (NR1 and NR2A) was measured in certain areas of the male rat brain (striatum, prefrontal cortex, hippocampus, hypothalamus and amygdala).
Transcription (expression) of NR1 in prefrontal associated with nmda receptor, hippocampus and amygdala
10) Confidence 0.66 Published 2008 Journal Pharmacology Section Abstract Doc Link 18391508 Disease Relevance 0 Pain Relevance 0.64
In contrast to the case for NAcc, in CeA we found an increased mRNA level for the NR1 subunit only but unchanged protein levels of all three subunits in morphine-dependent rats.
Transcription (found) of NR1 subunit in CeA associated with nucleus accumbens, amygdala and morphine
11) Confidence 0.65 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16453311 Disease Relevance 0.07 Pain Relevance 1.65
Under these conditions, mRNA and protein levels of NR1, NR2A and NR2B subunits did not change in the spinal cord of chronic ethanol-fed rats.
Transcription (levels) of NR1 in spinal cord associated with spinal cord
12) Confidence 0.63 Published 2007 Journal Life Sci. Section Abstract Doc Link 17156796 Disease Relevance 0.49 Pain Relevance 0.78
The NR1-C1 splice variant mRNA was not detected in untreated and saline control rats, or 2 and 7 days following TNBS treatment.
Neg (not) Transcription (detected) of NR1
13) Confidence 0.61 Published 2006 Journal Mol Pain Section Body Doc Link PMC1402265 Disease Relevance 0.40 Pain Relevance 0.08
Parallel to the protein expression, the mRNA of NR1-N1 plus and NR1-C1 were also present at 14, 21 and 28 days after TNBS treatment.
Transcription (present) of NR1
14) Confidence 0.58 Published 2006 Journal Mol Pain Section Body Doc Link PMC1402265 Disease Relevance 0.51 Pain Relevance 0.29
Finally, repeated dosing with MTEP (2 mg/kg i.p.) caused significant reductions in expression of the mRNA encoding the NR1 subunit of the N-methyl-D-aspartate receptor and the GluR2 subunit of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor in the cingulate cortex.
Transcription (expression) of NR1 in cingulate cortex associated with nmda receptor
15) Confidence 0.58 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16014750 Disease Relevance 0.76 Pain Relevance 0.52
Our results focused on mRNA expression and not protein expression or functional NMDAR changes after hypoxia and recovery.
Transcription (expression) of NMDAR associated with hypoxia
16) Confidence 0.58 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 0.55 Pain Relevance 0.12
To analyze NR1 and NR2 protein a sample of the denaturing buffer containing 20 ?
Spec (analyze) Transcription (analyze) of NR1
17) Confidence 0.56 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0 Pain Relevance 0
The expression of the transcript of the NR1 was enhanced in hippocampus and nucleus accumbens but attenuated in spinal cord.
Transcription (transcript) of NR1 in hippocampus associated with nucleus accumbens, hippocampus and spinal cord
18) Confidence 0.53 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10978586 Disease Relevance 0.23 Pain Relevance 1.07
We have previously, demonstrated an increase in the C1 cassette of NR1 mRNA expression at 14, 21, and 28 days following TNBS administration.
Transcription (expression) of NR1
19) Confidence 0.52 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16942839 Disease Relevance 0.65 Pain Relevance 0.38
Only NR1 mRNA expression could be detected in bipolar cells, and no NMDAR subunit mRNA expression was detected in rods [74].
Transcription (expression) of NR1
20) Confidence 0.52 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 1.12 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox