INT50440

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Context Info
Confidence 0.36
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.14
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pnp) extracellular region (Pnp) transferase activity, transferring glycosyl groups (Pnp)
cytoskeleton (Pnp) nucleus (Pnp) intracellular (Pnp)
Anatomy Link Frequency
B cells 1
lumen 1
Pnp (Mus musculus)
Pain Link Frequency Relevance Heat
endometriosis 13 100.00 Very High Very High Very High
diabetic neuropathy 6 100.00 Very High Very High Very High
unmyelinated 2 86.60 High High
visual analogue scale 1 82.56 Quite High
Bile 1 75.68 Quite High
nociceptor 2 25.00 Low Low
pain pelvic 1 25.00 Low Low
Analgesic 3 10.00 Low Low
agonist 10 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis (extended) 13 100.00 Very High Very High Very High
Diabetic Neuropathy 6 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 3 99.62 Very High Very High Very High
Immunization 30 98.52 Very High Very High Very High
Disease 3 96.04 Very High Very High Very High
Pruritus 2 95.08 Very High Very High Very High
Diabetes Mellitus 1 91.96 High High
Adhesions 2 86.28 High High
Nociception 1 86.08 High High
Reprotox - General 3 5 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, histamine induced vasodilatation was significantly impaired in all stages of PNP.
Negative_regulation (impaired) of PNP associated with diabetic neuropathy and increased venous pressure under development
1) Confidence 0.36 Published 1995 Journal Acta Neurol. Scand. Section Abstract Doc Link 7625149 Disease Relevance 0.95 Pain Relevance 0.37
Nevertheless, dalargin associated with PBCA NP and polysorbate 80 induced a potent and prolonged analgesia, which could not be obtained using PS NP in place of PBCA NP.
Negative_regulation (using) of NP
2) Confidence 0.34 Published 1999 Journal Pharm. Res. Section Body Doc Link 10644071 Disease Relevance 0 Pain Relevance 0
Although a similar reduction in NP-specific IgM was not observed at day 7 after immunization, this time point coincided with the return of MZ B cells to the spleen after integrin treatment and MZ B cell depletion (Fig.
Negative_regulation (reduction) of NP-specific in B cells associated with immunization
3) Confidence 0.02 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.28 Pain Relevance 0
This might lead to a reduced amount of VSV-NP or SV-NP entering the ER lumen for surface presentation through human TAP heterodimers.
Negative_regulation (reduced) of VSV-NP in lumen
4) Confidence 0.01 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.06 Pain Relevance 0
Group 1 target genes are up-regulated during the normal window of implantation but significantly decreased in women with endometriosis: IL-15, proline-rich protein, B61, Dickkopf-1, glycodelin, N-acetylglucosamine-6-O-sulfotransferase, G0S2 protein, and purine nucleoside phosphorylase.
Negative_regulation (decreased) of purine nucleoside phosphorylase associated with endometriosis
5) Confidence 0.01 Published 2003 Journal Endocrinology Section Abstract Doc Link 12810542 Disease Relevance 0.85 Pain Relevance 0.28

General Comments

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