INT50453

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Context Info
Confidence 0.45
First Reported 1995
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.60
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HBG2) transport (HBG2)
Anatomy Link Frequency
blood 2
erythrocytes 2
HBG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 8 100.00 Very High Very High Very High
Antihistamine 2 86.56 High High
alcohol 2 84.40 Quite High
lidocaine 15 84.20 Quite High
Acute pain 1 50.00 Quite Low
local anesthetic 1 38.72 Quite Low
Pain 8 10.00 Low Low
headache 2 5.84 Low Low
cva 11 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 4 99.38 Very High Very High Very High
Anaemia 4 98.32 Very High Very High Very High
Respiratory Disease 1 94.68 High High
Toxicity 23 93.24 High High
Methemoglobinemia 48 92.00 High High
Nicotine Addiction 9 90.68 High High
Obesity 1 78.56 Quite High
Reprotox - General 1 4 74.08 Quite High
Overdose 1 63.44 Quite High
Body Weight 2 55.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Meta-analytic techniques revealed that methemoglobin concentrations did not differ between EMLA-treated and placebo-treated infants (weighted mean di


Neg (not) Regulation (differ) of Gene_expression (concentrations) of methemoglobin
1) Confidence 0.45 Published 1998 Journal Pediatrics Section Body Doc Link 9445511 Disease Relevance 0 Pain Relevance 0
Of these, 233 (65%) used medications that could affect methemoglobin levels including those classified as "nitrosatable" drugs (i.e. a therapeutic drug that contains amides or amines).
Regulation (affect) of Gene_expression (levels) of methemoglobin
2) Confidence 0.43 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0.31 Pain Relevance 0.17
To achieve this goal, we analyzed blood pressure changes and blood nitrite, nitrate, S-nitrosothiols and methemoglobin levels of each subject before the infusion, during and after the infusion to determine the safe dose for future trials.
Regulation (nitrosothiols) of Gene_expression (levels) of methemoglobin in blood associated with cv unclassified under development
3) Confidence 0.41 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018414 Disease Relevance 0.26 Pain Relevance 0
The effects of acetaminophen (0.3-14.5 microM) on methemoglobin levels, superoxide dismutase and Na(+)-K+ ATPase activities of normal and vitamin E or vitamin C pretreated erythrocytes were investigated.
Regulation (effects) of Gene_expression (levels) of methemoglobin in erythrocytes associated with paracetamol
4) Confidence 0.39 Published 1995 Journal Biochem. Mol. Biol. Int. Section Abstract Doc Link 7627122 Disease Relevance 0 Pain Relevance 0.49
This trend was still evident after mean methemoglobin levels were controlled or adjusted for covariates, ?
Regulation (controlled) of Gene_expression (levels) of methemoglobin
5) Confidence 0.38 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0 Pain Relevance 0
Although hemoglobin level does not directly affect the production of methemoglobin, it does affect the amount of functional anemia.
Neg (not) Regulation (affect) of Gene_expression (production) of methemoglobin associated with anaemia
6) Confidence 0.13 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2263062 Disease Relevance 1.03 Pain Relevance 0.19

General Comments

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