INT50453

Context Info Confidence 0.45 First Reported 1995 Last Reported 2011 Negated 2 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 1.60 Pain Relevance 0.86

cytosol (HBG2) transport (HBG2)

Anatomy Link Frequency blood 2 erythrocytes 2 HBG2 (Homo sapiens)

Pain Link Frequency Relevance Heat Paracetamol 8 100.00 Antihistamine 2 86.56 alcohol 2 84.40 lidocaine 15 84.20 Acute pain 1 50.00 local anesthetic 1 38.72 Pain 8 10.00 headache 2 5.84 cva 11 5.00 ischemia 4 5.00

Disease Link Frequency Relevance Heat Cv Unclassified Under Development 4 99.38 Anaemia 4 98.32 Respiratory Disease 1 94.68 Toxicity 23 93.24 Methemoglobinemia 48 92.00 Nicotine Addiction 9 90.68 Obesity 1 78.56 Reprotox - General 1 4 74.08 Overdose 1 63.44 Body Weight 2 55.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Meta-analytic techniques revealed that methemoglobin concentrations did not differ between EMLA-treated and placebo-treated infants (weighted mean di

Neg (not) Regulation (differ) of Gene_expression (concentrations) of methemoglobin

1) Confidence 0.45 Published 1998 Journal Pediatrics Section Body Doc Link 9445511 Disease Relevance 0 Pain Relevance 0

Of these, 233 (65%) used medications that could affect methemoglobin levels including those classified as "nitrosatable" drugs (i.e. a therapeutic drug that contains amides or amines).

Regulation (affect) of Gene_expression (levels) of methemoglobin

2) Confidence 0.43 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0.31 Pain Relevance 0.17

To achieve this goal, we analyzed blood pressure changes and blood nitrite, nitrate, S-nitrosothiols and methemoglobin levels of each subject before the infusion, during and after the infusion to determine the safe dose for future trials.

Regulation (nitrosothiols) of Gene_expression (levels) of methemoglobin in blood associated with cv unclassified under development

3) Confidence 0.41 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018414 Disease Relevance 0.26 Pain Relevance 0

The effects of acetaminophen (0.3-14.5 microM) on methemoglobin levels, superoxide dismutase and Na(+)-K+ ATPase activities of normal and vitamin E or vitamin C pretreated erythrocytes were investigated.

Regulation (effects) of Gene_expression (levels) of methemoglobin in erythrocytes associated with paracetamol

4) Confidence 0.39 Published 1995 Journal Biochem. Mol. Biol. Int. Section Abstract Doc Link 7627122 Disease Relevance 0 Pain Relevance 0.49

This trend was still evident after mean methemoglobin levels were controlled or adjusted for covariates, ?

Regulation (controlled) of Gene_expression (levels) of methemoglobin

5) Confidence 0.38 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0 Pain Relevance 0

Although hemoglobin level does not directly affect the production of methemoglobin, it does affect the amount of functional anemia.

Neg (not) Regulation (affect) of Gene_expression (production) of methemoglobin associated with anaemia

6) Confidence 0.13 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2263062 Disease Relevance 1.03 Pain Relevance 0.19

General Comments

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