INT50454

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Context Info
Confidence 0.44
First Reported 1995
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.56
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (DNAH8) cytoskeleton (DNAH8) cilium (DNAH8)
cytoplasm (DNAH8)
Anatomy Link Frequency
erythrocytes 2
Caco-2 2
DNAH8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 6 100.00 Very High Very High Very High
cytokine 44 97.00 Very High Very High Very High
Inflammation 77 96.60 Very High Very High Very High
Inflammatory mediators 40 81.56 Quite High
abdominal pain 1 80.80 Quite High
agonist 10 60.64 Quite High
Dopamine 2 55.40 Quite High
aspirin 3 48.52 Quite Low
cINOD 11 47.80 Quite Low
tetrodotoxin 1 37.68 Quite Low
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 18 100.00 Very High Very High Very High
Hyperoxia 7 98.00 Very High Very High Very High
INFLAMMATION 122 96.60 Very High Very High Very High
Diarrhoea 18 92.96 High High
Death 1 92.60 High High
Disease 19 92.56 High High
Parkinson's Disease 2 92.00 High High
Infection 2 87.44 High High
Immune System Diseases 2 86.88 High High
Hypersensitivity 8 86.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Changes in demands for Na+ transport alter expression of the Na+,K+ -ATPase subunit isoforms.
Regulation (alter) of Gene_expression (expression) of ATPase
1) Confidence 0.44 Published 2000 Journal Mol. Cell. Biochem. Section Abstract Doc Link 11055550 Disease Relevance 0 Pain Relevance 0
The effects of acetaminophen (0.3-14.5 microM) on methemoglobin levels, superoxide dismutase and Na(+)-K+ ATPase activities of normal and vitamin E or vitamin C pretreated erythrocytes were investigated.
Regulation (effects) of Gene_expression (activities) of ATPase in erythrocytes associated with paracetamol
2) Confidence 0.34 Published 1995 Journal Biochem. Mol. Biol. Int. Section Abstract Doc Link 7627122 Disease Relevance 0 Pain Relevance 0.50
The effect of UC on the expression of apical Na+ channels (ENaC) and basolateral Na+, K+-ATPase, the critical determinants of electrogenic Na+ transport, was therefore investigated in this study.
Spec (investigated) Regulation (effect) of Gene_expression (expression) of ATPase associated with inflammatory bowel disease
3) Confidence 0.11 Published 2004 Journal J. Pathol. Section Abstract Doc Link 15307141 Disease Relevance 0.78 Pain Relevance 0.08
Another study however noted that interferon gamma reduced Na/K ATPase activity without change in Na K ATPase expression in human intestinal Caco-2 cells [59].
Neg (without) Regulation (change) of Gene_expression (expression) of ATPase in Caco-2
4) Confidence 0.04 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.23 Pain Relevance 0
Specific H,K-ATPase activity was calculated as the difference in microsomal ATPase activities in the presence and absence of the specific reversible gastric H,K-ATPase inhibitor SCH28080, and was expressed as ?
Regulation (difference) of Gene_expression (activities) of ATPase
5) Confidence 0.03 Published 2004 Journal BMC Gastroenterol Section Body Doc Link PMC368434 Disease Relevance 0 Pain Relevance 0
This down regulation affects not only protein function but also gene expression of ENaC and/or Na/K ATPase.
Regulation (affects) of Gene_expression (expression) of ATPase
6) Confidence 0.02 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.93 Pain Relevance 0.39
Hyperoxia results in an uncoupled oxidative phosphorylation in the mitochondrial respiration chain through a change in the expression levels of Cytochrome b, an important component of Complex III, and ATPase 6, 8, important components of enzyme complex V [35].
Regulation (change) of Gene_expression (expression) of ATPase associated with hyperoxia
7) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834759 Disease Relevance 0.63 Pain Relevance 0

General Comments

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