INT50454

Context Info Confidence 0.44 First Reported 1995 Last Reported 2010 Negated 1 Speculated 1 Reported most in Body Documents 6 Total Number 7 Disease Relevance 2.56 Pain Relevance 0.97

ATPase activity (DNAH8) cytoskeleton (DNAH8) cilium (DNAH8) cytoplasm (DNAH8)

Anatomy Link Frequency erythrocytes 2 Caco-2 2 DNAH8 (Homo sapiens)

Pain Link Frequency Relevance Heat Paracetamol 6 100.00 cytokine 44 97.00 Inflammation 77 96.60 Inflammatory mediators 40 81.56 abdominal pain 1 80.80 agonist 10 60.64 Dopamine 2 55.40 aspirin 3 48.52 cINOD 11 47.80 tetrodotoxin 1 37.68

Disease Link Frequency Relevance Heat Inflammatory Bowel Disease 18 100.00 Hyperoxia 7 98.00 INFLAMMATION 122 96.60 Diarrhoea 18 92.96 Death 1 92.60 Disease 19 92.56 Parkinson's Disease 2 92.00 Infection 2 87.44 Immune System Diseases 2 86.88 Hypersensitivity 8 86.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Changes in demands for Na+ transport alter expression of the Na+,K+ -ATPase subunit isoforms.

Regulation (alter) of Gene_expression (expression) of ATPase

1) Confidence 0.44 Published 2000 Journal Mol. Cell. Biochem. Section Abstract Doc Link 11055550 Disease Relevance 0 Pain Relevance 0

The effects of acetaminophen (0.3-14.5 microM) on methemoglobin levels, superoxide dismutase and Na(+)-K+ ATPase activities of normal and vitamin E or vitamin C pretreated erythrocytes were investigated.

Regulation (effects) of Gene_expression (activities) of ATPase in erythrocytes associated with paracetamol

2) Confidence 0.34 Published 1995 Journal Biochem. Mol. Biol. Int. Section Abstract Doc Link 7627122 Disease Relevance 0 Pain Relevance 0.50

The effect of UC on the expression of apical Na+ channels (ENaC) and basolateral Na+, K+-ATPase, the critical determinants of electrogenic Na+ transport, was therefore investigated in this study.

Spec (investigated) Regulation (effect) of Gene_expression (expression) of ATPase associated with inflammatory bowel disease

3) Confidence 0.11 Published 2004 Journal J. Pathol. Section Abstract Doc Link 15307141 Disease Relevance 0.78 Pain Relevance 0.08

Another study however noted that interferon gamma reduced Na/K ATPase activity without change in Na K ATPase expression in human intestinal Caco-2 cells [59].

Neg (without) Regulation (change) of Gene_expression (expression) of ATPase in Caco-2

4) Confidence 0.04 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.23 Pain Relevance 0

Specific H,K-ATPase activity was calculated as the difference in microsomal ATPase activities in the presence and absence of the specific reversible gastric H,K-ATPase inhibitor SCH28080, and was expressed as ?

Regulation (difference) of Gene_expression (activities) of ATPase

5) Confidence 0.03 Published 2004 Journal BMC Gastroenterol Section Body Doc Link PMC368434 Disease Relevance 0 Pain Relevance 0

This down regulation affects not only protein function but also gene expression of ENaC and/or Na/K ATPase.

Regulation (affects) of Gene_expression (expression) of ATPase

6) Confidence 0.02 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.93 Pain Relevance 0.39

Hyperoxia results in an uncoupled oxidative phosphorylation in the mitochondrial respiration chain through a change in the expression levels of Cytochrome b, an important component of Complex III, and ATPase 6, 8, important components of enzyme complex V [35].

Regulation (change) of Gene_expression (expression) of ATPase associated with hyperoxia

7) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834759 Disease Relevance 0.63 Pain Relevance 0

General Comments

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