INT50490

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Context Info
Confidence 0.48
First Reported 1995
Last Reported 2010
Negated 9
Speculated 4
Reported most in Abstract
Documents 80
Total Number 84
Disease Relevance 39.51
Pain Relevance 25.85

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small molecule metabolic process (PTGS2) endoplasmic reticulum (PTGS2) enzyme binding (PTGS2)
protein complex (PTGS2) cytoplasm (PTGS2) lipid binding (PTGS2)
Anatomy Link Frequency
amnion 2
spinal 2
monocytes 2
extracellular matrix 2
macrophage 1
PTGS2 (Homo sapiens)
PTGS2 - R106E (1)
Pain Link Frequency Relevance Heat
cINOD 227 100.00 Very High Very High Very High
Inflammation 208 100.00 Very High Very High Very High
cytokine 131 100.00 Very High Very High Very High
COX2 61 100.00 Very High Very High Very High
aspirin 36 100.00 Very High Very High Very High
Potency 14 100.00 Very High Very High Very High
Paracetamol 13 100.00 Very High Very High Very High
Bile 9 100.00 Very High Very High Very High
Gabapentin 1 100.00 Very High Very High Very High
Analgesic 14 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 330 100.00 Very High Very High Very High
Colon Cancer 59 100.00 Very High Very High Very High
Esophageal Disease 36 99.96 Very High Very High Very High
Hypoxia 30 99.84 Very High Very High Very High
Skin Cancer 17 99.78 Very High Very High Very High
Adenoma 35 99.74 Very High Very High Very High
Cancer 269 99.68 Very High Very High Very High
Hypertension 3 99.68 Very High Very High Very High
Necrosis 13 99.44 Very High Very High Very High
Experimental Autoimmune Neuritis 4 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indomethacin or lysine-acetylsalicylic acid concentration-dependently inhibited prostaglandin E(2) biosynthesis and, at concentrations causing near-complete inhibition, enhanced TNFalpha mRNA and protein expression without significantly influencing cyclooxygenase-2 mRNA.
Neg (without) Regulation (influencing) of cyclooxygenase-2 mRNA associated with aspirin
1) Confidence 0.48 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464057 Disease Relevance 0.14 Pain Relevance 0.28
In addition, in vitro studies indicate possible functional effects of the SNPs rs689466 and rs20417 on PTGS2 promoter activity (evaluated by a luciferase gene reporter system) [9,10] and on COX-2 activity (evaluated by PGE2 production in human monocytes) [47].
Spec (possible) Regulation (effects) of PTGS2 in monocytes
2) Confidence 0.45 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2992523 Disease Relevance 0.34 Pain Relevance 0
The effects of statins, nonsteroidal anti-inflammatory drugs, cyclooxygenase-2 inhibitors, and aspirin on colorectal cancer were estimated with conditional logistic regression adjusted for morbidity, smoking status, body mass index, and socioeconomic status.
Regulation (effects) of cyclooxygenase-2 in body
3) Confidence 0.44 Published 2007 Journal Gastroenterology Section Body Doc Link 17681160 Disease Relevance 0.18 Pain Relevance 0
A significant difference in gastrointestinal event rates was found among patients in this Medicaid population on nonsteroidal anti-inflammatory drug versus cyclooxygenase-2 inhibitors, when the gastroprotective agent use and the medication possession ratio were controlled for.
Regulation (controlled) of cyclooxygenase-2 associated with inflammation and cinod
4) Confidence 0.44 Published 2005 Journal Expert Rev Pharmacoecon Outcomes Res Section Abstract Doc Link 19807588 Disease Relevance 0.32 Pain Relevance 0.39
To determine whether the cyclooxygenase-2 selective inhibitor celecoxib affects CV risk, the incidence of CV events was analyzed in patients treated with celecoxib, placebo, or nonselective NSAIDs in the clinical trial database for celecoxib using defined Antiplatelet Trialists' Collaboration end points of nonfatal myocardial infarction, nonfatal stroke, and CV death.
Spec (whether) Regulation (affects) of cyclooxygenase-2 associated with stroke, cinod, death and myocardial infarction
5) Confidence 0.44 Published 2007 Journal Am. J. Cardiol. Section Abstract Doc Link 17196469 Disease Relevance 0.71 Pain Relevance 0.49
The data with respect to alteration in renal function, lower extremity edema, and hypertension indicates that cyclooxygenase-2 inhibitors affect the kidney in a manner similar to that of nonsteroidal anti-inflammatory drugs.
Regulation (affect) of cyclooxygenase-2 in kidney associated with pressure and volume under development, inflammation, hypertension and cinod
6) Confidence 0.44 Published 2002 Journal Curr Opin Rheumatol Section Abstract Doc Link 11981317 Disease Relevance 0.92 Pain Relevance 0.65
In addition, the biochemical properties of these isozymes, and the differential regulation of the PGHS-1 and PGHS-2 genes, will be examined.
Regulation (regulation) of PGHS-2
7) Confidence 0.42 Published 1995 Journal Semin. Nephrol. Section Abstract Doc Link 7631045 Disease Relevance 0.43 Pain Relevance 0.93
After obtaining the docking models and information about the PGH2 binding pocket, the goal was to compare these four predicted binding pockets and to determine the common features which facilitate the binding of the same substrate, PGH2.
Regulation (facilitate) of PGH2
8) Confidence 0.41 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC3009524 Disease Relevance 0 Pain Relevance 0
OBJECTIVE: To test the effect of selective and non-selective inhibitors of prostaglandin H synthase-2 (PGHS-II) on basal and cytokine-stimulated prostaglandin (PG) production by the immortalized human myometrial cell line, UTLRp16.
Regulation (effect) of prostaglandin H synthase-2 associated with cytokine
9) Confidence 0.40 Published 2002 Journal Eur. J. Obstet. Gynecol. Reprod. Biol. Section Abstract Doc Link 11750956 Disease Relevance 0.07 Pain Relevance 0.16
When comparing the inhibitory effects of a panel of PGHS-inhibitors in a whole cell human and murine PGHS-2 assay carried out under identical conditions, classical NSAIDs with the exception of aspirin and tenoxicam showed similar inhibitory effects on both human and murine PGHS-2 enzymes.
Regulation (effects) of PGHS-2 associated with aspirin and cinod
10) Confidence 0.39 Published 1997 Journal Inflammopharmacology Section Abstract Doc Link 17694360 Disease Relevance 0.08 Pain Relevance 0.19
Human endotoxin-stimulated adherent monocytes were used in order to determine whether or not NSAIDs influence cyclooxygenase-2 and/or tumor necrosis factor (TNF)alpha expression within the range of inhibitor concentrations that are required to suppress prostaglandin biosynthesis.
Neg (not) Spec (whether) Regulation (influence) of cyclooxygenase-2 in monocytes associated with necrosis, cancer and cinod
11) Confidence 0.35 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464057 Disease Relevance 0.20 Pain Relevance 0.13
Three SNPs in PTGS2 modulated esophagitis risk in our patient population: rs20417, rs5275, and rs689470.
Regulation (modulated) of PTGS2 associated with esophageal disease
12) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928273 Disease Relevance 0.95 Pain Relevance 0.14
BACKGROUND AND AIMS: Cyclooxygenase 2 (COX-2) is a target of aspirin and other non-steroidal anti-inflammatory drugs and is implicated in the pathogenesis of colorectal cancer.
Regulation (target) of Cyclooxygenase 2 associated with aspirin, inflammation, colon cancer, cinod and cox2
13) Confidence 0.34 Published 2004 Journal Eur J Gastroenterol Hepatol Section Abstract Doc Link 15167166 Disease Relevance 0.35 Pain Relevance 0.20
To determine whether the cyclooxygenase-2 (COX-2) inhibitor celecoxib affects cardiovascular thrombotic risk, we analyzed the incidence of cardiovascular events for celecoxib, placebo, and nonsteroidal anti-inflammatory drugs (NSAIDs) in the entire controlled, arthritis clinical trial database for celecoxib.
Spec (whether) Regulation (affects) of cyclooxygenase-2 associated with inflammation, cinod and arthritis
14) Confidence 0.33 Published 2003 Journal Am. J. Cardiol. Section Abstract Doc Link 12914871 Disease Relevance 0.45 Pain Relevance 0.33
The role of cyclooxygenase-2 inhibition for the prevention and treatment of prostate carcinoma.
Regulation (role) of cyclooxygenase-2 associated with prostate cancer and cox2
15) Confidence 0.33 Published 2003 Journal Clin Prostate Cancer Section Title Doc Link 15040874 Disease Relevance 0.60 Pain Relevance 0.22
Dexamethasone increases the PGHS-2 activity in confluent amnion cell cultures,62 and has no effect on PGHS-2 activity in freshly cultured amnion cells.63 In addition, dexamethasone suppressed cytokine induced PGHS-?
Neg (no) Regulation (effect) of PGHS-2 in amnion associated with dexamethasone and cytokine
16) Confidence 0.29 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2861440 Disease Relevance 0 Pain Relevance 0.21
In previous studies performed to elucidate acetaminophen mechanism of action, we demonstrated that acetaminophen inhibits prostaglandin E2 production by interleukin (IL)-1beta-stimulated T98G human astrocytic cells, without affecting cyclooxygenase-2 enzymatic activity.
Neg (without) Regulation (affecting) of cyclooxygenase-2 in T98G associated with paracetamol
17) Confidence 0.29 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14664905 Disease Relevance 0 Pain Relevance 0.33
The change in inhibitory potency of NS-398 on hPGHS-2(R106E) was due to a difference in the kinetics of inhibition, with NS-398 displaying time-dependent inhibition of hPGHS-2 but time-independent inhibition of PGHS-2(R106E).
Regulation (change) of hPGHS-2 (R106E) associated with potency
18) Confidence 0.28 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9351974 Disease Relevance 0.07 Pain Relevance 0.65
Various types of NSAIDs used in this study showed similar effects on the changes in PGD(2) release and PGHS-2 protein amounts, except those on PGHS activity in cell homogenates; while indomethacin, aspirin, and NS-398 inhibited it, but nimesulide and acetaminophen did not.
Neg (except) Regulation (effects) of PGHS-2 protein associated with aspirin, paracetamol and cinod
19) Confidence 0.28 Published 2004 Journal Biol. Pharm. Bull. Section Abstract Doc Link 15256727 Disease Relevance 0.14 Pain Relevance 0.78
Effects of the selective cyclooxygenase-2 inhibitor analgesic celecoxib on renal carbonic anhydrase enzyme activity: a randomized, controlled trial.
Regulation (Effects) of cyclooxygenase-2 associated with analgesic
20) Confidence 0.28 Published 2006 Journal Am J Ther Section Title Doc Link 16772765 Disease Relevance 0.60 Pain Relevance 0.15

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