INT50491

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Context Info
Confidence 0.47
First Reported 1995
Last Reported 2009
Negated 3
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 6.00
Pain Relevance 5.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (PTGS1) small molecule metabolic process (PTGS1) aging (PTGS1)
Golgi apparatus (PTGS1) endoplasmic reticulum (PTGS1) lipid metabolic process (PTGS1)
Anatomy Link Frequency
be cell 2
PGE2 2
blood 2
leucocytes 2
stomach 2
PTGS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 18 100.00 Very High Very High Very High
cOX1 12 100.00 Very High Very High Very High
lidocaine 2 100.00 Very High Very High Very High
cytokine 9 99.84 Very High Very High Very High
Perioperative pain 3 99.84 Very High Very High Very High
Pain 10 99.80 Very High Very High Very High
Codeine 2 99.66 Very High Very High Very High
cINOD 89 99.58 Very High Very High Very High
aspirin 11 99.52 Very High Very High Very High
Inflammation 23 98.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 20 100.00 Very High Very High Very High
Post Operative Pain 3 99.84 Very High Very High Very High
Pain 10 99.80 Very High Very High Very High
Cancer 69 99.40 Very High Very High Very High
INFLAMMATION 44 99.30 Very High Very High Very High
Injury 5 99.28 Very High Very High Very High
Asthma 3 98.64 Very High Very High Very High
Nociception 2 97.60 Very High Very High Very High
Hemorrhage 2 96.44 Very High Very High Very High
Toxicity 7 94.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The suppressive effects of propofol were ascribed to its inhibition of cyclooxygenase-2 activity rather than to effects on cyclooxygenase protein expression or substrate availability.
Regulation (effects) of Gene_expression (expression) of cyclooxygenase protein
1) Confidence 0.47 Published 2009 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 19951072 Disease Relevance 0.26 Pain Relevance 0.17
Alternative targets on the cyclooxygenase/prostaglandin signaling axis
Regulation (targets) of Gene_expression (axis) of cyclooxygenase/prostaglandin
2) Confidence 0.36 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206709 Disease Relevance 0.93 Pain Relevance 0.19
The differential effects of bupivacaine and lidocaine on prostaglandin E2 release, cyclooxygenase gene expression and pain in a clinical pain model.
Regulation (effects) of Gene_expression (expression) of cyclooxygenase associated with pain, lidocaine and codeine
3) Confidence 0.32 Published 2008 Journal Anesth. Analg. Section Title Doc Link 18165598 Disease Relevance 0.39 Pain Relevance 0.78
In the present study, we describe the proinflammatory effects of bupivacaine on local prostaglandin E2 (PGE2) production and cyclooxygenase (COX) gene expression that increases postoperative pain in human subjects.
Regulation (effects) of Gene_expression (expression) of cyclooxygenase in PGE2 associated with perioperative pain
4) Confidence 0.28 Published 2008 Journal Anesth. Analg. Section Abstract Doc Link 18165598 Disease Relevance 0.44 Pain Relevance 0.47
If the new PGHS-2 selective NSAIDs can effectively inhibit inflammatory prostaglandin synthesis by PGHS-2, without inhibiting PGHS-1 prostaglandin synthesis required to regulate sodium and water resorption, and renal blood flow, it is likely that these new drugs will also have significantly less renal toxicity than present-day NSAIDs.
Regulation (regulate) of Gene_expression (synthesis) of PGHS-1 in blood associated with toxicity, inflammation and cinod
5) Confidence 0.25 Published 1995 Journal Semin. Nephrol. Section Abstract Doc Link 7631045 Disease Relevance 0.51 Pain Relevance 1.11
Alternative splicing of cyclooxygenase-1 gene: altered expression in leucocytes from patients with bronchial asthma and association with aspirin-induced 15-HETE release.
Regulation (altered) of Gene_expression (expression) of cyclooxygenase-1 in leucocytes associated with asthma and aspirin
6) Confidence 0.19 Published 2007 Journal Allergy Section Title Doc Link 17508966 Disease Relevance 0.70 Pain Relevance 0.45
We provide comprehensive knowledge on the differential regulation of expression and catalysis of cyclooxygenase (COX)-1 and COX-2 in health and disease which represents an essential requirement to read out the clinical consequences of selective and nonselective inhibition of COX-isozymes in humans.
Regulation (regulation) of Gene_expression (expression) of cyclooxygenase associated with disease
7) Confidence 0.16 Published 2007 Journal Prostaglandins Other Lipid Mediat. Section Abstract Doc Link 17164136 Disease Relevance 0.24 Pain Relevance 0.11
Despite inhibiting of PGE2 generation, both nitric oxide-releasing derivatives and native aspirin and naproxen failed to affect expression of cyclooxygenase-1 mRNA but upregulated the cyclooxygenase-2 mRNA.
Neg (failed) Regulation (affect) of Gene_expression (expression) of cyclooxygenase-1 mRNA
8) Confidence 0.10 Published 2000 Journal Dig Liver Dis Section Body Doc Link 11142556 Disease Relevance 0.06 Pain Relevance 0
Cyclooxygenase expression in microglia and neurons in Alzheimer's disease and control brain.
Regulation (control) of in brain Gene_expression (expression) of Cyclooxygenase in microglia associated with disease and cox1
9) Confidence 0.09 Published 2001 Journal Acta Neuropathol. Section Title Doc Link 11194936 Disease Relevance 0.93 Pain Relevance 0.43
At 2 to 4 hours after surgery, PTGS1 expression was slightly decreased (36%, P < .001) and PTGS2 expression was markedly increased (300%, P < .001) with wide interindividual variation; at 48 hours after surgery, little detectable change in PTGS1 and PTGS2 expression was found in the control group.
Neg (little) Regulation (change) of Gene_expression (expression) of PTGS1
10) Confidence 0.09 Published 2006 Journal Clin. Pharmacol. Ther. Section Body Doc Link 16678543 Disease Relevance 0 Pain Relevance 0
Cyclooxygenase, in either isoform cox1 or cox2 control synthesis of PGE2, which regulates expression of MMP-9.
Regulation (isoform) of Gene_expression (synthesis) of Cyclooxygenase
11) Confidence 0.09 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993941 Disease Relevance 0.24 Pain Relevance 0.30
Cyclooxygenase, in either isoform cox1 or cox2 control synthesis of PGE2, which regulates expression of MMP-9.
Regulation (control) of Gene_expression (synthesis) of Cyclooxygenase
12) Confidence 0.09 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993941 Disease Relevance 0.24 Pain Relevance 0.30
The structure of human cyclooxygenase genes and their expression and regulation have been reviewed elsewhere [10].
Regulation (regulation) of Gene_expression (expression) of cyclooxygenase
13) Confidence 0.07 Published 2004 Journal Genome Biol Section Body Doc Link PMC522864 Disease Relevance 0 Pain Relevance 0
Nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to modulate cyclooxygenase (COX)-2 expression, but the mechanisms involved are controversial and may be cell specific.
Regulation (modulate) of Gene_expression (expression) of cyclooxygenase in be cell associated with inflammation and cinod
14) Confidence 0.07 Published 2003 Journal J. Immunol. Section Abstract Doc Link 12517972 Disease Relevance 0.17 Pain Relevance 0.32
At the end of observation, cyclooxygenase-1 mRNA expression was unchanged, whereas cyclooxygenase-2 mRNA was significantly induced.
Neg (unchanged) Regulation (unchanged) of Gene_expression (expression) of cyclooxygenase-1 mRNA
15) Confidence 0.07 Published 2006 Journal Anesthesiology Section Body Doc Link 16394701 Disease Relevance 0 Pain Relevance 0
Differential regulation of interleukin-6 and inducible cyclooxygenase gene expression by cytokines through prostaglandin-dependent and -independent mechanisms in human dental pulp fibroblasts.
Regulation (regulation) of Gene_expression (expression) of cyclooxygenase gene in dental pulp associated with cox2 and cytokine
16) Confidence 0.05 Published 2002 Journal J Endod Section Title Doc Link 12017180 Disease Relevance 0.27 Pain Relevance 0.30
So far NSAIDs-caused mucosal injury was attributed to their inhibitory effects on the activity of cyclooxygenase-1 (COX-1) which is expressed and shown to play a crucial role for the mucosal protection via producing prostaglandin E2 in the stomach.
Regulation (effects) of Gene_expression (expressed) of cyclooxygenase-1 in stomach associated with injury and cinod
17) Confidence 0.01 Published 2003 Journal J Nippon Med Sch Section Abstract Doc Link 12646969 Disease Relevance 0.60 Pain Relevance 0.47

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