INT505

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Context Info
Confidence 0.67
First Reported 1979
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 89
Total Number 89
Disease Relevance 69.38
Pain Relevance 14.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GPT) small molecule metabolic process (GPT) biosynthetic process (GPT)
cellular nitrogen compound metabolic process (GPT) cytoplasm (GPT)
Anatomy Link Frequency
liver 11
blood 7
upper 6
plasma 3
thorax 1
GPT (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 10 99.98 Very High Very High Very High
peripheral neuropathy 3 99.78 Very High Very High Very High
Pain 79 99.74 Very High Very High Very High
anesthesia 41 99.44 Very High Very High Very High
withdrawal 13 99.32 Very High Very High Very High
abdominal pain 16 99.04 Very High Very High Very High
Bile 60 99.00 Very High Very High Very High
Paracetamol 34 98.16 Very High Very High Very High
cINOD 113 97.92 Very High Very High Very High
headache 39 97.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Vomiting 65 99.96 Very High Very High Very High
Congenital Anomalies 50 99.96 Very High Very High Very High
Pressure Volume 2 Under Development 10 99.96 Very High Very High Very High
Exanthema 12 99.90 Very High Very High Very High
Thrombocytopenia 8 99.90 Very High Very High Very High
Neutropenia 16 99.88 Very High Very High Very High
Peripheral Neuropathy 3 99.78 Very High Very High Very High
Myalgia 17 99.74 Very High Very High Very High
Hepatotoxicity 41 99.66 Very High Very High Very High
Liver Disease 36 99.66 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
"Severe liver disease" was defined as a patient having both elevated alanine aminotransferase and aspartate aminotransferase 5 times above the normal reference values.
Positive_regulation (elevated) of alanine aminotransferase in liver associated with liver disease
1) Confidence 0.67 Published 2010 Journal AIDS Res Ther Section Body Doc Link PMC3001414 Disease Relevance 0.80 Pain Relevance 0.09
Laboratory tests showed high levels of serum amylase, GOT, GPT and total bilirubin.
Positive_regulation (levels) of GPT
2) Confidence 0.67 Published 2005 Journal Allergol Immunopathol (Madr) Section Abstract Doc Link 15946633 Disease Relevance 0.92 Pain Relevance 0.57
Laboratory abnormalities were recorded in 125(7.75%) of 1,279 adults and 85(19.23%) of 442 children, which included eosinophilia, neutropenia, and increases of GOT and GPT, and so on.
Positive_regulation (increases) of GPT associated with neutropenia, congenital anomalies and eosinophilia
3) Confidence 0.67 Published 2000 Journal Jpn J Antibiot Section Abstract Doc Link 12572096 Disease Relevance 0.58 Pain Relevance 0.09
We experienced transient increases of AST/ALT in a few cases, subcutaneous emphysema in one case, pleural effusion and ascites in two cases, but conservative treatments were effective for all cases.
Positive_regulation (increases) of ALT associated with pleural effusion, pressure and volume under development and subcutaneous emphysema
4) Confidence 0.67 Published 2001 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 11707986 Disease Relevance 0.63 Pain Relevance 0.10
Slight elevations of GOT, GPT and LDH in laboratory tests were observed in 1 patient (2.4%), but these values returned to normal after the completion of treatment.
Positive_regulation (elevations) of GPT
5) Confidence 0.67 Published 1999 Journal Jpn J Antibiot Section Abstract Doc Link 10202685 Disease Relevance 0.58 Pain Relevance 0.09
INVESTIGATIONS: Biochemical tests were unremarkable except for an increased GPT concentration, slight fasting hyperglycemia and hypertriglyceridemia.
Neg (except) Positive_regulation (increased) of GPT
6) Confidence 0.67 Published 1998 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 9861888 Disease Relevance 0.19 Pain Relevance 0
As for abnormal laboratory test, transient increases in GOT, GPT, Al-P, LDH, serum Na, Cl and decrease in serum K were observed in 9 patients (11.4%).
Positive_regulation (increases) of GPT
7) Confidence 0.67 Published 1996 Journal Jpn J Antibiot Section Abstract Doc Link 8851308 Disease Relevance 1.38 Pain Relevance 0.10
The serum LDH, GOT, GPT, ALP and gamma-GTP levels were elevated, and antibodies to Epstein-Barr viral capsid, early, and nuclear antigens were diagnostic of a primary Epstein-Barr virus infection.
Positive_regulation (elevated) of GPT associated with infection
8) Confidence 0.67 Published 1996 Journal Rinsho Ketsueki Section Abstract Doc Link 8827884 Disease Relevance 0.52 Pain Relevance 0.10
Abnormal laboratory findings noted were 6 cases of increased GOT, GPT, LDH, total bilirubin and/or creatinine, but none of these was serious or clinically problematic in particular.
Positive_regulation (increased) of GPT
9) Confidence 0.67 Published 1995 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 7611760 Disease Relevance 0.93 Pain Relevance 0.10
The most common adverse reactions were pyrexia, abdominal pain, queasiness and blood pressure increase;abnormalities in clinical laboratory data included hepatic function with increased AST (GOT), increased ALT (GPT), decreased cholinesterase, increased LDH and increased total bilirubin.
Positive_regulation (increased) of GPT in blood associated with adverse drug reaction, abdominal pain, congenital anomalies and fever
10) Confidence 0.67 Published 2005 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 16227743 Disease Relevance 1.18 Pain Relevance 0.10
Preoperative serum examination revealed increases in GOT, GPT, LDH and total bilirubin, decreases in cholinesterase and albumin, and prolongation of prothrombin time.
Positive_regulation (increases) of GPT
11) Confidence 0.67 Published 2007 Journal Masui Section Abstract Doc Link 17243650 Disease Relevance 0.37 Pain Relevance 0.66
Acute liver failure was defined as increased total bilirubin and/or prothrombin time greater than 60 s and/or International Normalized Ratio above 1.8 and/or hepatic encephalopathy developing up to 8 weeks after the beginning of liver disease associated with increased aspartate aminotransferase and alanine aminotransferase levels.
Positive_regulation (increased) of alanine aminotransferase in liver associated with liver disease, hepatic encephalopathy and acute liver failure
12) Confidence 0.67 Published 2006 Journal Crit Care Section Body Doc Link PMC1550879 Disease Relevance 0.90 Pain Relevance 0.05
Persistent increases of alanine aminotransferase to four times the upper limit of normal were rare, and no significant difference was found between the treatment groups (14 [0·2%] allocated 80 mg simvastatin vs ten [0·2%] allocated 20 mg simvastatin; p=0·5; table 4).
Positive_regulation (increases) of alanine aminotransferase in upper
13) Confidence 0.67 Published 2010 Journal Lancet Section Body Doc Link PMC2988223 Disease Relevance 0.97 Pain Relevance 0.06
Other AEs were reported in 20 of 234 patients, including nausea (2 patients), pain at the injection site (1), increased systolic/diastolic blood pressure (2), increased blood glucose (2), decreased white blood cell count (2), increased blood bilirubin (3), increased blood phosphorus (1), increased alanine aminotransferase (1), increased aspartate aminotransferase (1), hypertension (4), and hypotension (2).46

Effect of hepatic and renal impairment

Positive_regulation (increased) of alanine aminotransferase in blood associated with pain, pressure volume 2 under development, hypertension and vomiting
14) Confidence 0.67 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2921257 Disease Relevance 0.45 Pain Relevance 0.10
Liver function test abnormalities were defined as elevation of aspartate aminotransferase (AST) or alanine aminotransferase (ALT) above the upper range of reference values (40 IU/mL).
Positive_regulation (elevation) of ALT in upper associated with congenital anomalies
15) Confidence 0.67 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2826747 Disease Relevance 0.36 Pain Relevance 0.71
Liver function test abnormalities were defined as elevation of aspartate aminotransferase (AST) or alanine aminotransferase (ALT) above the upper range of reference values (40 IU/mL).
Positive_regulation (elevation) of alanine aminotransferase in upper associated with congenital anomalies
16) Confidence 0.67 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2826747 Disease Relevance 0.36 Pain Relevance 0.71
Group A comprised percutaneous liver biopsies in 14 patients with mildly elevated alanine aminotransferase in whom all causes of liver disease had been ruled out.
Positive_regulation (elevated) of alanine aminotransferase in liver associated with liver disease
17) Confidence 0.67 Published 2008 Journal Hepatology (Baltimore, Md.) Section Abstract Doc Link PMC2816363 Disease Relevance 0.16 Pain Relevance 0.03
Group A comprised percutaneous normal liver biopsy specimens, obtained from 14 adults with mildly elevated serum alanine aminotransferase activity addressed to Beaujon Hospital (Clichy, France), in whom all causes of liver disease had been ruled out (medication, alcohol, chronic viral hepatitis, autoimmune processes, and metabolic disease).
Positive_regulation (elevated) of alanine aminotransferase in liver associated with liver disease, metabolic disorder, hepatitis virus infection and alcohol
18) Confidence 0.67 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 1.26 Pain Relevance 0.35
Peng (1999) described patients receiving levofloxacin who experienced elevated alanine aminotransferase, potassium, blood urea nitrogen, and hemoglobin, but these laboratory changes were not attributed to levofloxacin therapy.
Positive_regulation (elevated) of alanine aminotransferase in blood
19) Confidence 0.67 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621400 Disease Relevance 1.37 Pain Relevance 0.13
Inclusion criteria were age above 18 years, symptoms (fever or jaundice) lasting less than 21 days, and elevated serum alanine aminotransferase (ALT) ?
Positive_regulation (elevated) of alanine aminotransferase associated with jaundice and fever
20) Confidence 0.67 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605267 Disease Relevance 0.96 Pain Relevance 0

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