INT5050

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Context Info
Confidence 0.62
First Reported 1985
Last Reported 2010
Negated 52
Speculated 44
Reported most in Abstract
Documents 149
Total Number 196
Disease Relevance 41.25
Pain Relevance 148.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) aging (Calca) extracellular region (Calca)
nucleus (Calca) intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
neurons 34
nerve 28
spinal cord 16
spinal 12
trachea 12
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 1153 100.00 Very High Very High Very High
Glutamate 966 100.00 Very High Very High Very High
qutenza 712 100.00 Very High Very High Very High
Calcium channel 487 100.00 Very High Very High Very High
Neurotransmitter 486 100.00 Very High Very High Very High
antagonist 289 100.00 Very High Very High Very High
Pain 189 100.00 Very High Very High Very High
agonist 175 100.00 Very High Very High Very High
Inflammation 165 100.00 Very High Very High Very High
Spinal cord 122 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 158 100.00 Very High Very High Very High
Pain 142 100.00 Very High Very High Very High
Neurogenic Inflammation 48 100.00 Very High Very High Very High
Neuropathic Pain 35 100.00 Very High Very High Very High
Hypertension 7 100.00 Very High Very High Very High
Natriuresis 2 100.00 Very High Very High Very High
Hyperalgesia 53 99.96 Very High Very High Very High
Myocardial Infarction 1 99.96 Very High Very High Very High
Headache 407 99.84 Very High Very High Very High
Depression 33 99.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Changes in the neurogenic release of calcitonin gene-related peptide (CGRP) by perivascular nerve stimulation (PNS) were investigated in perfused mesenteric vascular beds isolated from spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY).
Spec (investigated) Regulation (Changes) of Localization (release) of CGRP in nerve associated with hypertension and calcitonin gene-related peptide
1) Confidence 0.62 Published 1992 Journal Clin Exp Hypertens A Section Abstract Doc Link 1424225 Disease Relevance 0.17 Pain Relevance 0.35
The purpose of this study is to clarify the effects of 17beta-estradiol and the Japanese herbal medicine Keishi-bukuryo-gan on the release and synthesis of calcitonin gene-related peptide (CGRP) in ovariectomized (OVX) rats.
Regulation (effects) of Localization (release) of calcitonin gene-related peptide associated with calcitonin gene-related peptide
2) Confidence 0.62 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14501156 Disease Relevance 0 Pain Relevance 0.45
However, the capsaicin-induced CGRP release was not affected by pretreatment with 6-hydroxydopamine, a neurotoxin that causes a complete degeneration of adrenergic nerve terminals.
Neg (not) Regulation (affected) of Localization (release) of CGRP in nerve associated with qutenza and calcitonin gene-related peptide
3) Confidence 0.62 Published 1996 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 8957683 Disease Relevance 0 Pain Relevance 1.48
Effect of sympathetic and parasympathetic mediators on the release of calcitonin gene-related peptide and prostaglandin E from rat dura mater, in vitro.
Regulation (Effect) of in parasympathetic Localization (release) of calcitonin gene-related peptide in dura mater associated with pain and calcitonin gene-related peptide
4) Confidence 0.62 Published 2006 Journal Cephalalgia Section Title Doc Link 16472334 Disease Relevance 0.25 Pain Relevance 0.68
The effect of perivascular nerve stimulation (PNS) and capsaicin treatment on the release of calcitonin gene-related peptide (CGRP) was examined by radioimmunoassay (RIA) in isolated, perfused rat mesenteric arteries.
Spec (examined) Regulation (effect) of Localization (release) of CGRP in nerve associated with qutenza and calcitonin gene-related peptide
5) Confidence 0.62 Published 1990 Journal Neurosci. Lett. Section Abstract Doc Link 2359517 Disease Relevance 0 Pain Relevance 0.78
[Effects of some physical and chemical factors on CGRP release from mesenteric arterial bed].
Regulation (Effects) of Localization (release) of CGRP associated with qutenza
6) Confidence 0.62 Published 1995 Journal Sheng Li Xue Bao Section Title Doc Link 8762448 Disease Relevance 0.09 Pain Relevance 0.50
This study investigated the presence of presynaptic CGRP receptors on CGRP nerves and the receptors' role in the regulation of CGRP release from these nerves.
Regulation (regulation) of Localization (release) of CGRP in nerves associated with calcitonin gene-related peptide
7) Confidence 0.62 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7507998 Disease Relevance 0.07 Pain Relevance 0.73
Influence of calcitonin gene-related peptide release on pH-induced mechanical depression in rat atria.
Regulation (Influence) of Localization (release) of calcitonin associated with qutenza, depression and calcitonin gene-related peptide
8) Confidence 0.62 Published 2001 Journal Jpn Heart J Section Title Doc Link 11693286 Disease Relevance 0.18 Pain Relevance 0.41
The effect of perivascular nerve stimulation (PNS) on the release of calcitonin gene-related peptide (CGRP) was examined by radioimmunoassay (RIA) in isolated, perfused rat mesenteric arteries.
Spec (examined) Regulation (effect) of Localization (release) of calcitonin gene-related peptide in nerve associated with calcitonin gene-related peptide
9) Confidence 0.62 Published 1989 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 2610699 Disease Relevance 0.07 Pain Relevance 0.41
OBJECTIVE: The goal of this study was to determine whether the physiological effects of carbon dioxide (CO(2)) involve regulation of CGRP secretion from trigeminal sensory neurons.
Spec (whether) Regulation (regulation) of Localization (secretion) of CGRP in sensory neurons
10) Confidence 0.62 Published 2007 Journal Headache Section Abstract Doc Link 18052948 Disease Relevance 0 Pain Relevance 0.04
Differential effects of the novel analgesic, S 12813-4, on the spinal release of substance P- and calcitonin gene-related peptide-like materials in the rat.
Regulation (effects) of Localization (release) of calcitonin gene-related peptide in spinal associated with analgesic, calcitonin gene-related peptide and substance p
11) Confidence 0.62 Published 1994 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 7520130 Disease Relevance 0 Pain Relevance 1.00
We investigated whether NE also affects stimulus-induced intracutaneous calcitonin gene-related peptide (CGRP) and secondary prostaglandin E2 (PGE2) release.
Spec (whether) Regulation (affects) of Localization (release) of calcitonin gene-related peptide in PGE2 associated with calcitonin gene-related peptide
12) Confidence 0.62 Published 2001 Journal Neuroreport Section Abstract Doc Link 11447314 Disease Relevance 0 Pain Relevance 0.51
Regulation of calcitonin gene-related peptide release from rat trigeminal nucleus caudalis slices in vitro.
Regulation (Regulation) of Localization (release) of calcitonin gene-related peptide in nucleus associated with qutenza and calcitonin gene-related peptide
13) Confidence 0.62 Published 2004 Journal Neurosci. Lett. Section Title Doc Link 15288426 Disease Relevance 0.09 Pain Relevance 0.94
The effect of cannabinoids on capsaicin-evoked calcitonin gene-related peptide (CGRP) release from the isolated paw skin of diabetic and non-diabetic rats.
Regulation (effect) of Localization (release) of CGRP in skin associated with qutenza, diabetes mellitus, cannabinoid and calcitonin gene-related peptide
14) Confidence 0.62 Published 2002 Journal Neuropharmacology Section Title Doc Link 12069907 Disease Relevance 1.17 Pain Relevance 1.61
The effect of extracellular calcium on the release of calcitonin gene-related peptide (CGRP) induced by electrical field stimulation from enteric nerves of isolated rat ileum was studied; the effect of high potassium, veratridine and caffeine was also examined.
Spec (examined) Regulation (effect) of Localization (release) of CGRP in ileum associated with calcitonin gene-related peptide
15) Confidence 0.62 Published 1988 Journal Regul. Pept. Section Abstract Doc Link 2466307 Disease Relevance 0 Pain Relevance 0.42
The data obtained demonstrate the selective effect of opiates on calcitonin secretion.
Regulation (effect) of Localization (secretion) of calcitonin associated with opiate
16) Confidence 0.62 Published 1985 Journal Endocrinologie Section Abstract Doc Link 4048819 Disease Relevance 0 Pain Relevance 0.52
Of the enkephalins, only 5 leuenkephalin had a borderline effect on calcitonin secretion, stimulating to a significant degree the rise of the hormone.
Regulation (effect) of Localization (secretion) of calcitonin associated with enkephalin
17) Confidence 0.62 Published 1985 Journal Endocrinologie Section Abstract Doc Link 4048819 Disease Relevance 0 Pain Relevance 0.53
The effect of some enkephalins on calcitonin secretion.
Regulation (effect) of Localization (secretion) of calcitonin associated with enkephalin
18) Confidence 0.62 Published 1985 Journal Endocrinologie Section Title Doc Link 4048819 Disease Relevance 0 Pain Relevance 0.65
Exposure to high NO donor concentrations did not affect basal or stimulated CGRP release.
Neg (not) Regulation (affect) of Localization (release) of CGRP associated with calcitonin gene-related peptide
19) Confidence 0.61 Published 2009 Journal Neuropeptides Section Abstract Doc Link 19864020 Disease Relevance 0.27 Pain Relevance 0.52
In the present study we investigated the effects of the flurbiprofen enantiomers on the stimulated release of calcitonin gene-related peptide (CGRP) from the isolated rat skin as an indirect measure of peripheral nociceptor activation and 'neurogenic inflammation'.
Spec (investigated) Regulation (effects) of Localization (release) of calcitonin gene-related peptide in nociceptor associated with inflammation, nociceptor, neurogenic inflammation and calcitonin gene-related peptide
20) Confidence 0.61 Published 2003 Journal Inflamm. Res. Section Abstract Doc Link 14991081 Disease Relevance 0.26 Pain Relevance 0.32

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