INT50535

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Context Info
Confidence 0.51
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 25
Total Number 25
Disease Relevance 9.25
Pain Relevance 2.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (CA3) cytoplasm (CA3)
Anatomy Link Frequency
neurons 10
hippocampus 3
neuronal 2
CAR 2
pyramidal cell 1
CA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 144 100.00 Very High Very High Very High
hyperexcitability 26 99.44 Very High Very High Very High
Glutamate 150 99.40 Very High Very High Very High
long-term potentiation 88 99.00 Very High Very High Very High
ischemia 106 98.20 Very High Very High Very High
Chronic pancreatitis 2 97.70 Very High Very High Very High
Pyramidal cell 62 97.48 Very High Very High Very High
Inflammatory response 56 96.56 Very High Very High Very High
Inflammation 82 93.52 High High
nMDA receptor 35 91.84 High High
Disease Link Frequency Relevance Heat
Injury 61 99.66 Very High Very High Very High
Stress 1144 99.52 Very High Very High Very High
Hypoxia 22 99.34 Very High Very High Very High
Pancreatic Cancer 10 99.04 Very High Very High Very High
Drug Induced Neurotoxicity 8 98.84 Very High Very High Very High
Cv Unclassified Under Development 94 98.20 Very High Very High Very High
Cancer 27 98.20 Very High Very High Very High
Convulsion 40 98.06 Very High Very High Very High
Pancreatitis 2 97.70 Very High Very High Very High
Disease 407 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After treatment with ROS-generating agents, such as duroquinone, stress-response genes in CA1 are consistently expressed at higher levels than their counterparts in CA3, indicating that the stress level stays higher in vulnerable neurons before reaching the point of neuronal death (Wang et al., 2007).
Gene_expression (expressed) of CA3 in neuronal associated with stress and death
1) Confidence 0.51 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.62 Pain Relevance 0.06
Despite their physical proximity and cell morphological similarity, CA1 and CA3 neurons respond to OS very differently.
Gene_expression (neurons) of CA3 in neurons associated with stress
2) Confidence 0.50 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 1.02 Pain Relevance 0.19
This MoAb, which defines a mucin-like antigen (CAR-3) expressed by a large fraction of pancreatic cancers, shows in fact favourable in vivo localizing properties in the experimental animal model of human tumor xenograft. 131I-AR-3-IgG1 was injected i.v. into 5 patients with suspected pancreatic cancer.
Gene_expression (expressed) of CAR-3 in CAR associated with cancer and pancreatic cancer
3) Confidence 0.45 Published 1994 Journal J Nucl Biol Med Section Abstract Doc Link 7632759 Disease Relevance 0.46 Pain Relevance 0
Currently available evidence shows that mitochondria isolated from CA1 neurons release more ROS than those from CA3 neurons (Mattiasson et al., 2003a).
Gene_expression (neurons) of CA3 in neurons
4) Confidence 0.44 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.53 Pain Relevance 0.03
For example, CA1 neurons, but not CA3 neurons, require superoxide for LTP, and the use of scavengers of superoxide leads to impaired LTP in CA1 but not in CA3 (Klann, 1998; Thiels et al., 2000; Knapp and Klann, 2002; Huddleston et al., 2008).
Gene_expression (neurons) of CA3 in neurons associated with long-term potentiation
5) Confidence 0.44 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.14 Pain Relevance 0.23
Consistent with the higher ROS production and selective vulnerability of hippocampal CA1, neurons in this region exhibit lower expression of Ucp2 compared with those in CA3 (Richard et al., 2001).


Gene_expression (expression) of CA3 in neurons
6) Confidence 0.44 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.92 Pain Relevance 0.29
In another study, real-time monitoring of glutamate release from ischemic hippocampal slices also showed more glutamate being released from CA1 than CA3 neurons, with CA1 neurons being more susceptible to ischemia (Uchino et al., 2001).
Gene_expression (neurons) of CA3 in neurons associated with glutamate and ischemia
7) Confidence 0.44 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.63 Pain Relevance 0.55
A mapping of basal condition CA1/CA3 microarray data to an OS response pathway that consists of induced antioxidant and repressed ROS-producing genes (Morel and Barouki, 1999), showed that CA1 neurons express both anti-oxidant and ROS-producing genes at significantly higher levels than those in CA3 (Wang et al., 2005).
Gene_expression (express) of CA3 in neurons associated with stress
8) Confidence 0.39 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.59 Pain Relevance 0
The significantly higher expression of this gene in CA1 than in CA3 is an additional indication of endogenously higher levels of OS status in the CA1 region.
Gene_expression (expression) of CA3 associated with stress
9) Confidence 0.39 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.47 Pain Relevance 0
Surgery confirmed pancreatic cancer in 3 out of the 5 patients (chronic pancreatitis and periampullary cancer in one each); in all these 3 patients immunostaining with the MoAb AR-3 demonstrated the presence of the CAR-3 antigen (with a cytoplasmic and endoluminal/secretory pattern of distribution).
Gene_expression (presence) of CAR-3 in CAR associated with cancer, pancreatic cancer and chronic pancreatitis
10) Confidence 0.39 Published 1994 Journal J Nucl Biol Med Section Abstract Doc Link 7632759 Disease Relevance 0.60 Pain Relevance 0.10
The brain regions thought to be most sensitive to hypoxic/ischemic injury are the CA1 and CA3 regions of the hippocampus, cortical layers 3 and 5, medium spiny neurons of the striatum, and the Purkinje layer of the cerebellum.
Gene_expression (regions) of CA3 in neurons associated with hypoxia, injury and hippocampus
11) Confidence 0.39 Published 2008 Journal The Open Neuroimaging Journal Section Body Doc Link PMC2577938 Disease Relevance 1.31 Pain Relevance 0.18
Our results indicated that these cells were highly associated with thioflavin S-positive plaques in ITG sections, but not in DG or CA3 regions of the hippocampus.
Neg (not) Gene_expression (regions) of CA3 in hippocampus associated with hippocampus
12) Confidence 0.22 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 0.83 Pain Relevance 0.22
In the CA3 region, we started counting at the CA3 boundary, and counted 5 consecutive, 1-mm2 reticle fields covering the pyramidal cell layers.
Gene_expression (boundary) of CA3 in pyramidal cell associated with pyramidal cell
13) Confidence 0.22 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 0.23 Pain Relevance 0.07
Despite this dose being insufficient to produce seizure or any clinical signs of neurotoxicity, it did induce morphologic changes, predominately in the CA3 region of the hippocampus, including: cytoplasmic vacuolization of neurons and astrocytes, as well as injury to the mitochondria in the pyramidal cells.
Gene_expression (region) of CA3 in hippocampus associated with drug induced neurotoxicity, convulsion, pyramidal cell, injury and hippocampus
14) Confidence 0.14 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0.47 Pain Relevance 0.14
Most of the experiments were carried out in CA1; however, in some experiments recordings were made in CA3.
Gene_expression (made) of CA3
15) Confidence 0.13 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1950312 Disease Relevance 0 Pain Relevance 0
The measures of ripples were similar between CA1 and CA3 as well, although the ripple episodes were slightly longer in CA1 than in CA3, but not significantly so.
Gene_expression (similar) of CA3
16) Confidence 0.13 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1950312 Disease Relevance 0 Pain Relevance 0
L of Ca3 dye containing 2.5?
Gene_expression (dye) of Ca3
17) Confidence 0.12 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2947157 Disease Relevance 0 Pain Relevance 0.15
In the CA3 area of the hippocampus, Caspr2 (A and B) is strongly expressed in the stratum radiatum (rad), whereas Kv1.1 (A) and Lgi1 (B) are most prominent in the mossy fibre layer (mf) where Caspr2 is almost absent.
Gene_expression (expressed) of CA3 in hippocampus associated with hippocampus
18) Confidence 0.12 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.12 Pain Relevance 0.24
The three T-channel subtypes present in CA3 neurons, CaV3.1, CaV3.2 and CaV3.3, exhibit distinct functional properties [29], [39].
Gene_expression (neurons) of CA3 in neurons
19) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2323611 Disease Relevance 0 Pain Relevance 0.03
Mechanisms of CA3 bursting
Gene_expression (bursting) of CA3
20) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2323611 Disease Relevance 0.09 Pain Relevance 0.06

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