INT50539

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Context Info
Confidence 0.60
First Reported 1994
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.05
Pain Relevance 1.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Pvalb)
Anatomy Link Frequency
neurons 2
neuronal 1
inner nuclear layer 1
tooth pulp 1
lateral division 1
Pvalb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 6 99.80 Very High Very High Very High
dexamethasone 128 99.78 Very High Very High Very High
Hippocampus 14 98.90 Very High Very High Very High
trigeminal ganglion 5 97.88 Very High Very High Very High
Cholecystokinin 2 97.86 Very High Very High Very High
substance P 2 97.44 Very High Very High Very High
Neuronal excitability 4 95.98 Very High Very High Very High
Enkephalin 1 94.48 High High
GABAergic 1 94.14 High High
Neuropeptide 4 93.52 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 71 99.08 Very High Very High Very High
Depression 32 17.64 Low Low
Cognitive Disorder 25 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 24 5.00 Very Low Very Low Very Low
Body Weight 9 5.00 Very Low Very Low Very Low
Li-fraumeni Syndrome 6 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Frailty 4 5.00 Very Low Very Low Very Low
Shock 3 5.00 Very Low Very Low Very Low
Pulmonary Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given that GABAergic disinhibition may serve as a mechanism for generalized enhancement of neuronal excitability and parvalbumin-expressing interneurons have been reported to play a key role in coordinating of neuronal network excitability of the hippocampus [28], we then examined whether neonatal DEX treatment affects parvalbumin-expressing interneurons.
Spec (whether) Regulation (affects) of parvalbumin in neuronal associated with neuronal excitability, gabaergic, hippocampus and dexamethasone
1) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943478 Disease Relevance 0 Pain Relevance 0.54
Approximately 30 and 50% of the labeled cells were immunoreactive for parvalbumin and calcitonin gene-related peptide (CGRP), respectively.
Regulation (immunoreactive) of parvalbumin associated with calcitonin gene-related peptide
2) Confidence 0.32 Published 1995 Journal Brain Res. Section Abstract Doc Link 7633881 Disease Relevance 0.10 Pain Relevance 0.30
Morphometric analysis confirmed that the number of parvalbumin-immunoreactive neurons was not markedly changed (4.6%; NS) by oxaliplatin treatment, but their size was reduced as evident from significant changes in their mean cell body area (-29%; P = 0.047) and in the percentage of large neurons (>1750 ?
Neg (not) Regulation (changed) of parvalbumin in neurons
3) Confidence 0.21 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785764 Disease Relevance 0.36 Pain Relevance 0.18
Moreover, as many as 41% of the VRL-1-immunoreactive tooth pulp neurons co-expressed parvalbumin immunoreactivity.
Regulation (immunoreactivity) of parvalbumin in tooth pulp
4) Confidence 0.16 Published 2000 Journal Neuroscience Section Abstract Doc Link 11113320 Disease Relevance 0.21 Pain Relevance 0.23
Parvalbumin immunoreactivity was never detected in the VRL-1-immunoreactive cutaneous neurons.
Regulation (immunoreactivity) of Parvalbumin in neurons
5) Confidence 0.14 Published 2000 Journal Neuroscience Section Abstract Doc Link 11113320 Disease Relevance 0.20 Pain Relevance 0.23
Parvalbumin immunoreactivity was observed mainly in the retinal inner part, and in particular in the inner nuclear layer (Fig. 3B).
Regulation (immunoreactivity) of Parvalbumin in inner nuclear layer
6) Confidence 0.13 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2576503 Disease Relevance 0.18 Pain Relevance 0
In contrast, substance P- and cholecystokinin-immunoreactive neurons were more abundant in the medial division, whereas carbonic anhydrase activity and parvalbumin immunoreactivity were stronger in the lateral division.
Regulation (immunoreactivity) of parvalbumin in lateral division associated with cholecystokinin and substance p
7) Confidence 0.02 Published 1994 Journal J. Comp. Neurol. Section Abstract Doc Link 7884044 Disease Relevance 0 Pain Relevance 0.41

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