INT5055

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Context Info
Confidence 0.69
First Reported 1992
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 89
Total Number 96
Disease Relevance 64.03
Pain Relevance 23.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IFNG) extracellular region (IFNG)
Anatomy Link Frequency
monocytes 5
blood 4
T cells 4
Plasma 2
macrophage 2
IFNG (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 344 100.00 Very High Very High Very High
Anterior cingulate cortex 168 100.00 Very High Very High Very High
Multiple sclerosis 94 99.84 Very High Very High Very High
chemokine 52 99.84 Very High Very High Very High
monoamine 4 99.84 Very High Very High Very High
Inflammation 293 99.78 Very High Very High Very High
Morphine 33 99.76 Very High Very High Very High
Enkephalin 1 99.44 Very High Very High Very High
depression 16 99.24 Very High Very High Very High
antidepressant 10 99.18 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 721 100.00 Very High Very High Very High
Necrosis 48 100.00 Very High Very High Very High
Common Cold 88 99.84 Very High Very High Very High
Pressure And Volume Under Development 69 99.84 Very High Very High Very High
Demyelinating Disease 48 99.84 Very High Very High Very High
Acute Coronary Syndrome 15 99.82 Very High Very High Very High
INFLAMMATION 338 99.78 Very High Very High Very High
Myasthenia Gravis 2 99.70 Very High Very High Very High
Systemic Lupus Erythematosus 143 99.68 Very High Very High Very High
Alzheimer's Dementia 30 99.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, treatment with morphine resulted in a 31% and 36% increase in IFN gamma and IL-2 levels, respectively, during dual infection.
Positive_regulation (increase) of IFN gamma associated with infection and morphine
1) Confidence 0.69 Published 2003 Journal J. Acquir. Immune Defic. Syndr. Section Abstract Doc Link 12640199 Disease Relevance 1.31 Pain Relevance 1.14
Although IFN-gamma is a potent anti-tumor and inflammatory cytokine, increased levels of IFN-gamma were not associated with irAEs in our patients.
Positive_regulation (increased) of IFN-gamma associated with inflammation, cancer and cytokine
2) Confidence 0.67 Published 2008 Journal Cancer Immun. Section Abstract Doc Link 18503261 Disease Relevance 0.66 Pain Relevance 0.32
In the present study, we report that administration of double-stranded RNA, a classical inducer of interferon-gamma (IFN-gamma), causes rapid and persistent activation of microglia and astrocytes, as well as induction of interleukin-1beta (IL-beta) and nitric oxide synthase.
Positive_regulation (inducer) of interferon-gamma in astrocytes
3) Confidence 0.67 Published 2003 Journal Glia Section Abstract Doc Link 12951652 Disease Relevance 0.94 Pain Relevance 0.22
In the present study, we report that administration of double-stranded RNA, a classical inducer of interferon-gamma (IFN-gamma), causes rapid and persistent activation of microglia and astrocytes, as well as induction of interleukin-1beta (IL-beta) and nitric oxide synthase.
Positive_regulation (inducer) of IFN-gamma in astrocytes
4) Confidence 0.67 Published 2003 Journal Glia Section Abstract Doc Link 12951652 Disease Relevance 0.94 Pain Relevance 0.23
They highlight the importance of the co-activation of both the IFG and the posterior MTG in syntactic processing, but only in the left-hemisphere (Caplan et al., 1996; Just et al., 1996; Tyler and Marslen-Wilson, 2008; Tyler et al., 2010).
Positive_regulation (activation) of IFG in posterior
5) Confidence 0.66 Published 2010 Journal Brain Section Body Doc Link PMC2965424 Disease Relevance 0.14 Pain Relevance 0
Increased transforming growth factor-beta, interleukin-4, and interferon-gamma in multiple sclerosis.
Positive_regulation (Increased) of interferon-gamma associated with multiple sclerosis
6) Confidence 0.64 Published 1994 Journal Ann. Neurol. Section Title Doc Link 8080246 Disease Relevance 0.92 Pain Relevance 0.63
Furthermore, tenidap was found to inhibit IFN-gamma production as well as the induction of mRNA encoding IFN-gamma or TNF-alpha.
Positive_regulation (induction) of IFN-gamma
7) Confidence 0.63 Published 1995 Journal Scand. J. Immunol. Section Abstract Doc Link 8552993 Disease Relevance 0.56 Pain Relevance 0.50
During animal negative valence picture view, vegans activated the IFG bilaterally (MNI space coordinates: 54, 16, ?
Positive_regulation (activated) of IFG
8) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877098 Disease Relevance 0 Pain Relevance 0.07
On the other hand, the activation of the inferior prefrontal cortex (IFG) seen in vegans during animal suffering, which is consistent with a role of such a region in different emotional tasks [20], may be related to aspects of cognitive control during emotion processing.
Positive_regulation (activation) of IFG in IFG associated with cognitive disorder
9) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877098 Disease Relevance 0.35 Pain Relevance 0.36
In a previous study investigating age-related changes in language comprehension using the same task (Tyler et al., 2010) ageing was associated with increased right IFG activation homologous to the left-hemisphere activation produced by younger subjects in the context of syntactic processing.
Positive_regulation (activation) of IFG associated with aging
10) Confidence 0.57 Published 2010 Journal Brain Section Body Doc Link PMC2965424 Disease Relevance 0.15 Pain Relevance 0
Additionally, although good syntactic performance was associated with increasing activity in the left IFG, it was not associated with increasing activity in the right IFG.
Positive_regulation (increasing) of IFG
11) Confidence 0.57 Published 2010 Journal Brain Section Body Doc Link PMC2965424 Disease Relevance 0.17 Pain Relevance 0
Additional evidence for the role of the motor cortex in emotion perception comes from two studies showing that viewing an emotional facial expression interferes with a simple facial motor task, which translates into an increase of activity in the vPMC/IFG that is correlated with the intensity of the emotion (Wild et al. 2003; Lee et al. 2008).
Positive_regulation (increase) of IFG in cortex
12) Confidence 0.54 Published 2009 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2865077 Disease Relevance 0 Pain Relevance 0.12
We interpret our observed IFG activity accordingly: during periods when higher order action strategies are in greater flux, increased activity results in the IFG.
Positive_regulation (results) of IFG
13) Confidence 0.51 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762366 Disease Relevance 0 Pain Relevance 0.05
In addition, naloxone had an apparent additive effect on the morphine-associated enhancement of IFN gamma and IL-2 expression in the dual-infection model.
Positive_regulation (enhancement) of IFN gamma associated with narcan, infection and morphine
14) Confidence 0.50 Published 2003 Journal J. Acquir. Immune Defic. Syndr. Section Abstract Doc Link 12640199 Disease Relevance 1.25 Pain Relevance 1.22
HIV-1 infection of monocytes induced low levels of Quin while lipopolysaccharide (LPS) or interferon-gamma (IFN-gamma) activation of the virus-infected cells elicited 10-fold higher levels.
Positive_regulation (activation) of interferon-gamma in monocytes associated with acquired immune deficiency syndrome or hiv infection and infection
15) Confidence 0.50 Published 1996 Journal J. Neurovirol. Section Abstract Doc Link 8799202 Disease Relevance 1.38 Pain Relevance 0.09
HIV-1 infection of monocytes induced low levels of Quin while lipopolysaccharide (LPS) or interferon-gamma (IFN-gamma) activation of the virus-infected cells elicited 10-fold higher levels.
Positive_regulation (activation) of IFN-gamma in monocytes associated with acquired immune deficiency syndrome or hiv infection and infection
16) Confidence 0.50 Published 1996 Journal J. Neurovirol. Section Abstract Doc Link 8799202 Disease Relevance 1.37 Pain Relevance 0.08
We found a significant increase of IFNgamma and TNFalpha production (P<0.01) and a significant decrease of IL10 production (P<0.05) in cultures of lymphomonocytes taken from patients with AMI and UA compared with SA patients and controls.
Positive_regulation (increase) of IFNgamma associated with angina and myocardial infarction
17) Confidence 0.49 Published 2006 Journal Clin. Exp. Med. Section Abstract Doc Link 16550343 Disease Relevance 1.58 Pain Relevance 0.60
Proinflammatory cytokines such as interleukin (IL)-1, IL-6, and IL-18, interferon-gamma, tumor necrosis factor, and macrophage colony-stimulating factor are elevated in patients with adult-onset Still's disease and are thought to have a major role in the pathogenesis of the disease.
Positive_regulation (elevated) of interferon-gamma in macrophage associated with necrosis, cancer, disease and cytokine
18) Confidence 0.49 Published 2007 Journal Nature clinical practice. Rheumatology Section Abstract Doc Link 17538564 Disease Relevance 1.47 Pain Relevance 0.39
Antidepressants suppress production of the Th1 cytokine interferon-gamma, independent of monoamine transporter blockade.
Neg (independent) Positive_regulation (independent) of interferon-gamma associated with antidepressant, monoamine and cytokine
19) Confidence 0.49 Published 2006 Journal Eur Neuropsychopharmacol Section Title Doc Link 16388933 Disease Relevance 0.24 Pain Relevance 0.98
Interaction of a synthetic amyloid plaque (fibrillar Abeta) with microglia leads to a strong pro-inflammatory response, indicating that priming of immune cells with beta-amyloid potentiates their response to secondary stimuli such as AGE and cytokines such as interferon-gamma.
Positive_regulation (response) of interferon-gamma in plaque associated with inflammatory response, alzheimer's dementia, amyloid plaque, cytokine and abeta
20) Confidence 0.49 Published 2003 Journal Biochem. Soc. Trans. Section Abstract Doc Link 14641072 Disease Relevance 0.80 Pain Relevance 0.22

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