INT50558

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Context Info
Confidence 0.57
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 31
Total Number 31
Disease Relevance 13.97
Pain Relevance 2.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PCNA) nucleoplasm (PCNA) nucleolus (PCNA)
nucleus (PCNA) DNA binding (PCNA) transcription factor binding (PCNA)
Anatomy Link Frequency
liver 1
colon 1
pituitary 1
epithelial cell 1
PCNA (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 24 100.00 Very High Very High Very High
aspirin 26 98.96 Very High Very High Very High
Analgesic 3 98.96 Very High Very High Very High
Inflammation 110 96.00 Very High Very High Very High
cocaine 292 93.08 High High
COX-2 inhibitor 110 88.56 High High
Potency 8 87.72 High High
cINOD 78 87.32 High High
Pain 8 87.16 High High
headache 1 82.88 Quite High
Disease Link Frequency Relevance Heat
Breast Cancer 175 100.00 Very High Very High Very High
Repression 27 100.00 Very High Very High Very High
Hypertrophy 3 100.00 Very High Very High Very High
Sleep Disorders 81 99.84 Very High Very High Very High
Cancer 752 99.76 Very High Very High Very High
Suicidal Behaviour 54 99.22 Very High Very High Very High
Colon Cancer 216 98.92 Very High Very High Very High
Hepatocellular Cancer 94 98.64 Very High Very High Very High
Pituitary Cancer 15 98.22 Very High Very High Very High
Apoptosis 656 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The S phase block was accompanied by a reduction in the protein levels of cyclin A, cyclin B1, cyclin D1, cdc2, PCNA and the c-jun AP-1 component.
Negative_regulation (reduction) of PCNA
1) Confidence 0.57 Published 2003 Journal Int. J. Cancer Section Abstract Doc Link 14566835 Disease Relevance 0.53 Pain Relevance 0.06
Immunohistochemical analysis was used to define the different hormone types of the tumors and the expression of various immunologic targets, including the pituitary tumor transforming gene, basic fibroblast growth factor-2, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and proliferating cell nuclear antigen.
Negative_regulation (inhibitor) of proliferating cell nuclear antigen in pituitary associated with cancer, pituitary cancer and metalloproteinase
2) Confidence 0.42 Published 2009 Journal J Clin Neurosci Section Abstract Doc Link 19046883 Disease Relevance 1.11 Pain Relevance 0.18
CONCLUSIONS: Inducing apoptosis and inhibiting proliferation contribute to the anticancer activity of indomethacin via COX-2 independent pathway of Bfl-1, WISP-1 and PCNA.
Negative_regulation (pathway) of PCNA
3) Confidence 0.39 Published 2006 Journal Chin J Dig Dis Section Body Doc Link 17054584 Disease Relevance 0.06 Pain Relevance 0
increased in most cancer specimens versus mucosa, with a decrease in c-Myc and in PCNA proteins, suggesting that colon cancer growth is due to increased cell survival rather than increased proliferation.
Negative_regulation (decrease) of PCNA in colon associated with cancer and colon cancer
4) Confidence 0.33 Published 2007 Journal PPAR Research Section Abstract Doc Link PMC1852897 Disease Relevance 0.92 Pain Relevance 0.03
This effect was associated with a reduction of cyclin D level, a key protein involved in G1-S transition [54], and PCNA, thus increasing the processivity of DNA polymerase [82].
Negative_regulation (reduction) of PCNA
5) Confidence 0.25 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.70 Pain Relevance 0.13
Interestingly, meloxicam was also able to downregulate PCNA and cyclin A in HepG2 cell line (hepatocellular carcinoma cells), leading to an inhibition of the cell proliferation and an accumulation of the cells in G0/G1 phase of cell cycle [84].
Negative_regulation (downregulate) of PCNA associated with hepatocellular cancer
6) Confidence 0.25 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.98 Pain Relevance 0.20
In invasive human colonocytes butyrate inhibited urokinase plasminogen activator (uPA) activity, and downregulated PCNA and TP53 levels after exposure for 12–18 hours [77].
Negative_regulation (downregulated) of PCNA
7) Confidence 0.23 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.37 Pain Relevance 0.60
PCNA and KI-67 PIs of adenomatous and flat mucosa were significantly reduced (Wilcoxon's test, P < 0.05).
Negative_regulation (reduced) of PCNA
8) Confidence 0.21 Published 1995 Journal Dis. Colon Rectum Section Body Doc Link 7634976 Disease Relevance 0.13 Pain Relevance 0
PCNA, involved in DNA replication, was also downregulated by curcumin.
Negative_regulation (downregulated) of PCNA
9) Confidence 0.20 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.49 Pain Relevance 0
Salicylate-induced growth arrest is associated with inhibition of p70s6k and down-regulation of c-myc, cyclin D1, cyclin A, and proliferating cell nuclear antigen.
Negative_regulation (inhibition) of proliferating cell nuclear antigen associated with analgesic
10) Confidence 0.18 Published 2000 Journal J. Biol. Chem. Section Title Doc Link 10993886 Disease Relevance 0.28 Pain Relevance 0.34
Expression of cell growth related genes PCNA and IGFBP7 was downregulated by the high concentration of curcumin (Table 2).
Negative_regulation (downregulated) of PCNA
11) Confidence 0.17 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.05 Pain Relevance 0
M for 7 d) cell proliferation inhibition has been suggested to be related to increased expression of p21, a major transcriptional target of p53, as well as down-regulation of nuclear antigen (PCNA), an essential DNA replication factor [11].
Negative_regulation (down-regulation) of PCNA
12) Confidence 0.13 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.32 Pain Relevance 0.42
Adding to the earlier described findings, the increase of megalocytosis percentage, the decrease of PCNA-positive cells and cells showing mitosis phenotype also suggest anti-mitotic effects.
Negative_regulation (decrease) of PCNA
13) Confidence 0.08 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2862927 Disease Relevance 0.23 Pain Relevance 0.06
on both the expression and activity of cyclin-dependent kinase inhibitors [CDKI] such as p21 and p27.
Negative_regulation (inhibitors) of cyclin
14) Confidence 0.08 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208869 Disease Relevance 0.46 Pain Relevance 0
Gallic acid treatment significantly attenuated some alterations (i.e. increased levels of aspartate transaminase, alanine transaminase, alkaline phosphatase, acid phosphatase, lactate dehydrogenase, gamma-glutamyltransferase, 5'-nucleotidase, bilirubin, alpha-fetoprotein, carcinoembryonic antigen) and decreased the levels of argyophillic nucleolar organizing regions (AgNORs) and proliferating cell nuclear antigen (PCNA) [90].
Negative_regulation (decreased) of PCNA
15) Confidence 0.07 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 0.06 Pain Relevance 0
The reduction of cyclin
Negative_regulation (reduction) of cyclin
16) Confidence 0.07 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.14 Pain Relevance 0
The p21WAF1/CIP1 is a cyclin kinase inhibitor that can induce cell growth arrest by inactivating cyclin-dependent kinase (Cdk) or by inhibiting the activity of proliferating cell nuclear antigen (PCNA).
Negative_regulation (inhibiting) of PCNA
17) Confidence 0.06 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.25 Pain Relevance 0
It is unclear at this time why the coordinate activation of a suicide receptor and a hormone receptor would decrease both PCNA and p21/waf1, potentially compromising DNA repair capacity.
Negative_regulation (decrease) of PCNA associated with suicidal behaviour
18) Confidence 0.06 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.77 Pain Relevance 0
The lack of PCNA as a proliferative marker in monkeys may indicate some differences in the mechanism for liver hypertrophy between trout and primates and should be further explored.
Negative_regulation (explored) of PCNA in liver associated with hypertrophy
19) Confidence 0.05 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2516568 Disease Relevance 0.54 Pain Relevance 0.03
Concurrent exposure to estrogen and to soluble Fas-ligand (sFasL) suppressed p21/waf-1 and PCNA.
Negative_regulation (suppressed) of PCNA
20) Confidence 0.04 Published 2004 Journal BMC Neurosci Section Abstract Doc Link PMC395829 Disease Relevance 0.54 Pain Relevance 0

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