INT50559

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Context Info
Confidence 0.34
First Reported 1995
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.80
Pain Relevance 2.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA binding (A1cf) mRNA processing (A1cf) endoplasmic reticulum (A1cf)
nucleus (A1cf) intracellular (A1cf) cytoplasm (A1cf)
Anatomy Link Frequency
colon 1
brain 1
A1cf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 15 100.00 Very High Very High Very High
anesthesia 2 99.84 Very High Very High Very High
Dopamine 24 99.80 Very High Very High Very High
ketamine 7 99.62 Very High Very High Very High
local anesthetic 18 98.90 Very High Very High Very High
Inflammation 1 92.64 High High
positron emission tomography 1 90.92 High High
COX2 4 90.28 High High
cINOD 1 80.88 Quite High
lidocaine 4 68.96 Quite High
Disease Link Frequency Relevance Heat
Aberrant Crypt Foci 6 100.00 Very High Very High Very High
INFLAMMATION 2 92.64 High High
Body Weight 1 87.60 High High
Cancer 1 85.12 High High
Toxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To assess this possibility the inhibitory effects of nimesulide on the formation of ACF induced by azoxymethane in rat colon were investigated, and compared with those of piroxicam and sulindac.
ACF Binding (formation) of in colon associated with aberrant crypt foci
1) Confidence 0.34 Published 1996 Journal J. Cancer Res. Clin. Oncol. Section Abstract Doc Link 8601574 Disease Relevance 0.80 Pain Relevance 0.21
Of the local anesthetics tested, only dimethocaine showed full displacement of CFT binding (0-30 microM tested) and full inhibition of dopamine uptake (0-100 microM tested).
CFT Binding (binding) of associated with dopamine and local anesthetic
2) Confidence 0.23 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7635175 Disease Relevance 0 Pain Relevance 1.07
Dimethocaine was only slightly less potent than cocaine with an estimated Ki of 1.4 micorM and an IC50 value of 1.2 microM for [3H]CFT binding and dopamine uptake.
CFT Binding (binding) of associated with dopamine and cocaine
3) Confidence 0.23 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7635175 Disease Relevance 0 Pain Relevance 1.23
The effects of ketamine anesthesia on the binding of [(11)C]-labeled cocaine analogs, [(11)C]beta-CFT (2beta-carbomethoxy-3beta-(4-fluorophenyl)tropane) and [(11)C]beta-CIT-FE (N-(2-fluoroethyl)-2beta-carbomethoxy-3beta-(4-iodophenyl)tropane), to the striatal dopamine transporter (DAT) were evaluated in the monkey brain using positron emission tomography (PET).
beta-CFT Binding (binding) of in brain associated with dopamine, anesthesia, ketamine, positron emission tomography and cocaine
4) Confidence 0.02 Published 2001 Journal Synapse Section Abstract Doc Link 11746726 Disease Relevance 0 Pain Relevance 0.46

General Comments

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