INT5056

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Context Info
Confidence 0.78
First Reported 1986
Last Reported 2011
Negated 7
Speculated 6
Reported most in Abstract
Documents 216
Total Number 222
Disease Relevance 137.52
Pain Relevance 74.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IFNG) extracellular region (IFNG)
Anatomy Link Frequency
T cells 43
mononuclear cells 13
blood 13
natural killer cells 8
CSF 7
IFNG (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 1548 100.00 Very High Very High Very High
Inflammation 986 100.00 Very High Very High Very High
cINOD 123 100.00 Very High Very High Very High
methotrexate 21 100.00 Very High Very High Very High
agonist 100 99.92 Very High Very High Very High
Morphine 70 99.92 Very High Very High Very High
Enkephalin 21 99.92 Very High Very High Very High
nud 19 99.84 Very High Very High Very High
fluoxetine 15 99.84 Very High Very High Very High
antidepressant 69 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1125 100.00 Very High Very High Very High
Cancer 644 100.00 Very High Very High Very High
Recurrence 69 100.00 Very High Very High Very High
Endemic Invasive Fungal Infection 68 100.00 Very High Very High Very High
Necrosis 65 100.00 Very High Very High Very High
Disease 810 99.84 Very High Very High Very High
Diabetes Mellitus 177 99.84 Very High Very High Very High
Mycobacterial Infection 154 99.84 Very High Very High Very High
Inflammatory Breast Neoplasms 134 99.84 Very High Very High Very High
Bladder Cancer 22 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Circulating IFN-gamma was detectable at 3-12 h after an injection of 1.8 mg of rIFN-gamma, the highest dose given.
Gene_expression (detectable) of IFN-gamma
1) Confidence 0.78 Published 1994 Journal J Immunother Emphasis Tumor Immunol Section Abstract Doc Link 8061901 Disease Relevance 0.38 Pain Relevance 0.08
IFN-gamma was not detectable in ELF after subcutaneous injection.
Neg (not) Gene_expression (detectable) of IFN-gamma
2) Confidence 0.78 Published 1994 Journal J Immunother Emphasis Tumor Immunol Section Abstract Doc Link 8061901 Disease Relevance 0.34 Pain Relevance 0.06
These freshly isolated mononuclear cells had a significantly impaired capacity to generate superoxide anion (O2-) in response to phorbol myristate acetate (PMA), while production of IFN-gamma by concanavalin A-stimulated cells was intact.
Gene_expression (production) of IFN-gamma in mononuclear cells
3) Confidence 0.77 Published 1989 Journal J. Infect. Dis. Section Abstract Doc Link 2536791 Disease Relevance 0.07 Pain Relevance 0.64
Recent studies have shown that in vitro exposure of peripheral blood mononuclear cells (PBMC) to morphine results in suppressed respiratory-burst activity of monocytes and impaired interferon-gamma (IFN-gamma) production by lymphocytes.
Gene_expression (production) of interferon-gamma in respiratory associated with morphine
4) Confidence 0.77 Published 1989 Journal J. Infect. Dis. Section Abstract Doc Link 2536791 Disease Relevance 0 Pain Relevance 0.54
Recent studies have shown that in vitro exposure of peripheral blood mononuclear cells (PBMC) to morphine results in suppressed respiratory-burst activity of monocytes and impaired interferon-gamma (IFN-gamma) production by lymphocytes.
Gene_expression (production) of IFN-gamma in respiratory associated with morphine
5) Confidence 0.77 Published 1989 Journal J. Infect. Dis. Section Abstract Doc Link 2536791 Disease Relevance 0 Pain Relevance 0.54
Interferon-gamma (IFN-gamma) is produced by activated T cells and probably by NK cells.
Gene_expression (produced) of IFN-gamma in NK cells
6) Confidence 0.77 Published 1994 Journal Acta Haematol Pol Section Abstract Doc Link 8209610 Disease Relevance 0.11 Pain Relevance 0.03
Interferon-gamma (IFN-gamma) is produced by activated T cells and probably by NK cells.
Gene_expression (produced) of Interferon-gamma in NK cells
7) Confidence 0.77 Published 1994 Journal Acta Haematol Pol Section Abstract Doc Link 8209610 Disease Relevance 0.11 Pain Relevance 0.03
Despite the high levels of IFN gamma expression, the viability of the coinfected cells in the presence of morphine was maintained.
Gene_expression (expression) of IFN gamma associated with morphine
8) Confidence 0.77 Published 2003 Journal J. Acquir. Immune Defic. Syndr. Section Abstract Doc Link 12640199 Disease Relevance 1.20 Pain Relevance 1.22
Enhanced interferon-gamma production by lymphocytes induced by a mitogen from mycoplasma arthritidis in patients with ankylosing spondylitis.
Gene_expression (production) of interferon-gamma in lymphocytes associated with spinal inflammation and bacterial respiratory disease
9) Confidence 0.75 Published 1989 Journal Rheumatol. Int. Section Title Doc Link 2510239 Disease Relevance 0.66 Pain Relevance 0.38
BACKGROUND: Unstable angina (UA) is associated with systemic inflammation and with expansion of interferon-gamma-producing T lymphocytes.
Gene_expression (producing) of interferon-gamma in T lymphocytes associated with angina and inflammation
10) Confidence 0.75 Published 2000 Journal Circulation Section Abstract Doc Link 10869258 Disease Relevance 0.27 Pain Relevance 0.15
This study was carried out to examine the effects of antidepressive agents, i.e., imipramine, venlafaxine, L-5-hydroxytryptophan, and fluoxetine on the production of interferon-gamma (IFN-gamma), a proinflammatory cytokine, and interleukin-10 (IL-10), a negative immunoregulatory cytokine.
Gene_expression (production) of interferon-gamma associated with cytokine and fluoxetine
11) Confidence 0.75 Published 2001 Journal J Clin Psychopharmacol Section Abstract Doc Link 11270917 Disease Relevance 0.61 Pain Relevance 0.71
IL-18 is a cytokine which plays an important role in Th-1 response through its ability to induce IFN-gamma production in T cells and NK cells.
Gene_expression (production) of IFN-gamma in NK cells associated with cytokine
12) Confidence 0.75 Published 2001 Journal Acta Neurol. Scand. Section Abstract Doc Link 11551238 Disease Relevance 0.22 Pain Relevance 0.16
Antidepressants suppress production of the Th1 cytokine interferon-gamma, independent of monoamine transporter blockade.
Gene_expression (production) of interferon-gamma associated with antidepressant, monoamine and cytokine
13) Confidence 0.75 Published 2006 Journal Eur Neuropsychopharmacol Section Title Doc Link 16388933 Disease Relevance 0.24 Pain Relevance 0.97
Flow cytometric detection of intracellular IFN-gamma/IL-4/IL-17 cytokine production was employed to investigate Th1, Th2 and Th17 cells in colonic lamina propria and peripheral blood.
Gene_expression (production) of IFN-gamma in lamina
14) Confidence 0.75 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 20058616 Disease Relevance 0.08 Pain Relevance 0
We found a significant increase of IFNgamma and TNFalpha production (p<0.01) and a significant decrease of IL-10 production (p<0.01) in cultures of lymphomonocytes taken from patients with AMI and UA compared with SA patients and controls.
Gene_expression (production) of IFNgamma associated with angina and myocardial infarction
15) Confidence 0.75 Published 2005 Journal Int. J. Cardiol. Section Abstract Doc Link 16216352 Disease Relevance 1.90 Pain Relevance 1.01
Expression of interferon-gamma- inducible protein-10 and its receptor CXCR3 in chronic pancreatitis.
Gene_expression (Expression) of interferon-gamma associated with chronic pancreatitis
16) Confidence 0.75 Published 2007 Journal Pancreatology Section Title Doc Link 17912012 Disease Relevance 0.28 Pain Relevance 0.42
These immunocompetent cells produce cytokines such as TNF-a, IL-1-b, IL-6, IL- 8, IL-12, IL-23, and IFN-g, which further stimulate the local inflammation [25-29].
Gene_expression (produce) of IFN-g associated with inflammation and cytokine
17) Confidence 0.75 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2914086 Disease Relevance 1.33 Pain Relevance 0.46
We have examined proliferation of and interferon-gamma (IFN-gamma) production by peripheral blood lymphocytes induced by a purified mitogen derived from mycoplasma arthritidis (MAS) in patients with seronegative spondylo-arthropathies and healthy individuals.
Gene_expression (production) of interferon-gamma in lymphocytes associated with bacterial respiratory disease and arthropathy
18) Confidence 0.75 Published 1989 Journal Rheumatol. Int. Section Abstract Doc Link 2510239 Disease Relevance 0.49 Pain Relevance 0.22
We found a significant increase of IFNgamma and TNFalpha production (P<0.01) and a significant decrease of IL10 production (P<0.05) in cultures of lymphomonocytes taken from patients with AMI and UA compared with SA patients and controls.
Gene_expression (production) of IFNgamma associated with angina and myocardial infarction
19) Confidence 0.75 Published 2006 Journal Clin. Exp. Med. Section Abstract Doc Link 16550343 Disease Relevance 1.58 Pain Relevance 0.61
Relationships were significant between activated NK and T cell percentage and depression, anxiety, and overall distress (r = -0.54, -0.49, and -0.47, respectively, P < 0.03) and between interferon-gamma production and anxiety (r = -0.45, P < 0.03).
Gene_expression (production) of interferon-gamma in T cell associated with depression and anxiety disorder
20) Confidence 0.75 Published 2002 Journal Biol Res Nurs Section Abstract Doc Link 12363280 Disease Relevance 0.52 Pain Relevance 0.47

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