INT50568

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Context Info
Confidence 0.44
First Reported 1995
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 5.56
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 1
brain 1
HCA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 12 100.00 Very High Very High Very High
Serotonin 5 98.72 Very High Very High Very High
fluoxetine 6 98.56 Very High Very High Very High
adenocard 4 98.52 Very High Very High Very High
sSRI 5 98.32 Very High Very High Very High
cva 20 96.24 Very High Very High Very High
Pain 12 88.00 High High
headache 8 85.72 High High
abdominal pain 13 81.76 Quite High
imagery 11 79.12 Quite High
Disease Link Frequency Relevance Heat
Liver Cell Adenoma 60 100.00 Very High Very High Very High
Focal Nodular Hyperplasia 10 99.96 Very High Very High Very High
Spontaneous Rupture 5 99.64 Very High Very High Very High
Cancer 28 98.68 Very High Very High Very High
Malignant Neoplastic Disease 11 98.68 Very High Very High Very High
Appetite Loss 4 97.00 Very High Very High Very High
Necrosis 8 96.72 Very High Very High Very High
Weight Loss 80 96.56 Very High Very High Very High
Cv General 3 Under Development 20 96.24 Very High Very High Very High
Body Weight 52 93.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A few of the studies reported a positive effect of HCA on the blood lipid profile [6, 24, 29–31], while one did not find any significant difference between HCA and placebo on this blood parameter [2].
Positive_regulation (effect) of HCA in blood
1) Confidence 0.44 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC3010674 Disease Relevance 0.23 Pain Relevance 0.11
It is not clear if the higher HCA dosage ensures a higher bioavailability of HCA.
Positive_regulation (bioavailability) of HCA associated with bioavailability
2) Confidence 0.44 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC3010674 Disease Relevance 0.17 Pain Relevance 0.13
Two included studies which differed widely in results [25, 29] also differed widely in dosage of HCA.
Positive_regulation (dosage) of HCA
3) Confidence 0.44 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC3010674 Disease Relevance 0.12 Pain Relevance 0.09
HCA has also been reported to increase the release or availability of serotonin in the brain, thereby leading to appetite suppression [7].
Positive_regulation (increase) of HCA in brain associated with appetite loss and serotonin
4) Confidence 0.41 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC3010674 Disease Relevance 0.86 Pain Relevance 0.10
The dose of the HCA was increased to maximize efficacy and minimize side effects.
Positive_regulation (increased) of HCA
5) Confidence 0.39 Published 1995 Journal J Clin Psychiatry Section Body Doc Link 7635848 Disease Relevance 0 Pain Relevance 0
Unlike FNH, HCA is often symptomatic and is noted for its spontaneous rupture and malignant transformation.
Positive_regulation (noted) of HCA associated with malignant neoplastic disease, spontaneous rupture, focal nodular hyperplasia and liver cell adenoma
6) Confidence 0.36 Published 2005 Journal BMC Surg Section Body Doc Link PMC1087495 Disease Relevance 1.76 Pain Relevance 0.25
Colour Doppler US may provide some clues for distinguishing HCA from FNH, since the former shows a continuous venous flow in the central portion and either a pulsatile or continuous peripheral flow ('basket pattern').
Positive_regulation (distinguishing) of HCA associated with liver cell adenoma
7) Confidence 0.19 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1950307 Disease Relevance 1.55 Pain Relevance 0.22
During the last 30–40 years, there has been an increase in the incidence of hepatocellular adenoma (HCA), a rare primary benign hepatic tumour, in young and middle-aged women, which has been associated with the use of oral contraceptives (OCs) [1].
Positive_regulation (increase) of HCA associated with cancer and liver cell adenoma
8) Confidence 0.18 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1950307 Disease Relevance 0.82 Pain Relevance 0.18
The selective serotonin reuptake inhibitors (SSRI) fluoxetine, sertraline and citalopram have been investigated for their ability to activate two carbonic anhydrase (CA) isozymes, hCA I and hCA II, in parallel with two standard activators for which the X-ray structure (in complex with isozyme II) has been resolved: histamine and phenylalanine.
Spec (investigated) Positive_regulation (activate) of hCA I associated with ssri and fluoxetine
9) Confidence 0.00 Published 2003 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 12873510 Disease Relevance 0.05 Pain Relevance 0.54

General Comments

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