INT50569

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Context Info
Confidence 0.59
First Reported 1995
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 13
Disease Relevance 3.76
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

HCA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 8 99.32 Very High Very High Very High
Bioavailability 12 93.56 High High
Lasting pain 1 89.68 High High
Potency 4 87.92 High High
GABAergic 34 87.88 High High
adenocard 4 74.24 Quite High
Dorsal horn 6 65.68 Quite High
Serotonin 5 64.96 Quite High
Spinal cord 148 59.28 Quite High
imagery 7 53.52 Quite High
Disease Link Frequency Relevance Heat
Liver Cell Adenoma 23 100.00 Very High Very High Very High
Cv General 3 Under Development 8 99.32 Very High Very High Very High
Rupture 8 98.28 Very High Very High Very High
Generalized Anxiety Disorder 24 98.04 Very High Very High Very High
Body Weight 124 97.44 Very High Very High Very High
Dermatitis 2 97.20 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 97.00 Very High Very High Very High
Cancer 16 95.76 Very High Very High Very High
Appetite Loss 8 93.76 High High
Sprains And Strains 10 91.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Garcinia cambogia was the main source of HCA in most studies, with Garcinia atroviridis being the source of HCA in one included study [2].
Gene_expression (source) of HCA
1) Confidence 0.59 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC3010674 Disease Relevance 0.24 Pain Relevance 0.13
Garcinia cambogia was the main source of HCA in most studies, with Garcinia atroviridis being the source of HCA in one included study [2].
Gene_expression (source) of HCA
2) Confidence 0.59 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC3010674 Disease Relevance 0.24 Pain Relevance 0.13
The dosage of HCA used ranged from 1?
Gene_expression (dosage) of HCA
3) Confidence 0.59 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC3010674 Disease Relevance 0.06 Pain Relevance 0.07
HCA is a derivative of citric acid and can be found in plant species native to South Asia such as Garcinia cambogia, Garcinia indica, and Garcinia atroviridis [2].
Gene_expression (found) of HCA
4) Confidence 0.52 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC3010674 Disease Relevance 0.64 Pain Relevance 0.07
When using this drug combination, the clinician is cautioned to prescribe low doses of the HCA and monitor serum levels closely since fluoxetine can raise serum HCA levels.


Gene_expression (levels) of HCA
5) Confidence 0.51 Published 1995 Journal J Clin Psychiatry Section Body Doc Link 7635848 Disease Relevance 0 Pain Relevance 0
Elective resection of HCA has a mortality rate of less than 1%, whereas the mortality rate with free rupture is 5 to 10%.
Gene_expression (resection) of HCA associated with rupture and liver cell adenoma
6) Confidence 0.25 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1950307 Disease Relevance 1.44 Pain Relevance 0.17
In the single administration experiments, food intake were analyzed for the crossover experiments by a four-way ANOVA test with the factors, group of treatment order, animals within group, period and type of vehicle treatment, all per HCA preparation.
Gene_expression (preparation) of HCA
7) Confidence 0.20 Published 2005 Journal Nutr Metab (Lond) Section Body Doc Link PMC1242253 Disease Relevance 0.21 Pain Relevance 0
As most of the (ineffective) human studies used low dose CitriMax preparations, the present study may indicate that low doses of a relatively low-effective HCA preparation may have contributed to the lack of efficacy in several human studies.


Gene_expression (preparation) of HCA
8) Confidence 0.20 Published 2005 Journal Nutr Metab (Lond) Section Body Doc Link PMC1242253 Disease Relevance 0.07 Pain Relevance 0.04
It should be noted, however, that a decrease in food intake as a result of induction of malaise or discomfort by any of the used HCA sources cannot be excluded.
Gene_expression (sources) of HCA
9) Confidence 0.18 Published 2005 Journal Nutr Metab (Lond) Section Body Doc Link PMC1242253 Disease Relevance 0.09 Pain Relevance 0.03
To enable comparison between the effects of the different HCA treatments, the difference between 24 hrs cumulative food intake after component treatment and after vehicle treatment was calculated for each HCA source (defined as delta, data shown in table 2).
Gene_expression (source) of HCA
10) Confidence 0.18 Published 2005 Journal Nutr Metab (Lond) Section Body Doc Link PMC1242253 Disease Relevance 0.13 Pain Relevance 0
This is the reaction pattern expected for non-photosensitizing allergens such as NI (and HCA) and our in vitro results were in complete agreement with its clinical relevance (induction of allergic contact dermatitis) or its use as a model for metal allergens [40], [41], [42].
Gene_expression (results) of HCA associated with dermatitis
11) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.10 Pain Relevance 0
By 3–6 mo, ~ 5% of grafted HNu (+) cells in the avulsion cases and a slightly higher proportion of cells in HCA (?)
Gene_expression (proportion) of HCA
12) Confidence 0.12 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1796906 Disease Relevance 0 Pain Relevance 0.09
At that time point, a significant percentage of HNu (+) cells in all three experimental groups (avulsion: 60.5% ± 0.47%; HCA lesion: 56.4% ± 3.19%; sham: 49.57% ± 4.04%) were also GAD immunoreactive.
Gene_expression (lesion) of HCA associated with generalized anxiety disorder
13) Confidence 0.12 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1796906 Disease Relevance 0.54 Pain Relevance 0.15

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