INT5057

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Context Info
Confidence 0.58
First Reported 1989
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 23
Total Number 23
Disease Relevance 8.33
Pain Relevance 12.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IFNG) extracellular region (IFNG)
Anatomy Link Frequency
T-cell 14
mononuclear cells 6
PBL 2
respiratory 2
IFNG (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 177 100.00 Very High Very High Very High
agonist 40 100.00 Very High Very High Very High
antidepressant 50 99.98 Very High Very High Very High
nud 6 99.84 Very High Very High Very High
spastic colon 4 99.70 Very High Very High Very High
monoamine 20 99.32 Very High Very High Very High
corticosteroid 37 99.22 Very High Very High Very High
noradrenaline 15 99.20 Very High Very High Very High
Morphine 6 98.66 Very High Very High Very High
Serotonin 10 98.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Dyspepsia 6 99.84 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

3 99.70 Very High Very High Very High
Eczema 5 98.08 Very High Very High Very High
Asthma 321 96.56 Very High Very High Very High
Cerebral Toxoplasmosis 2 95.36 Very High Very High Very High
INFLAMMATION 154 95.04 Very High Very High Very High
Angina 3 94.92 High High
Injury 3 94.44 High High
Immune System Diseases 1 93.72 High High
Gastrointestinal Disease 5 90.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent studies have shown that in vitro exposure of peripheral blood mononuclear cells (PBMC) to morphine results in suppressed respiratory-burst activity of monocytes and impaired interferon-gamma (IFN-gamma) production by lymphocytes.
Negative_regulation (impaired) of in mononuclear cells Gene_expression (production) of interferon-gamma in respiratory associated with morphine
1) Confidence 0.58 Published 1989 Journal J. Infect. Dis. Section Abstract Doc Link 2536791 Disease Relevance 0 Pain Relevance 0.54
This suppression of IFN-gamma production was paralleled by reduced T-cell proliferation, therefore we suggest that the ability of antidepressants to suppress IFN-gamma production may be related to their anti-proliferative properties.
Negative_regulation (suppress) of Gene_expression (production) of IFN-gamma in T-cell associated with antidepressant
2) Confidence 0.56 Published 2006 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 16388933 Disease Relevance 0.23 Pain Relevance 1.07
The fact that trimipramine also suppressed IFN-gamma production and T-cell proliferation indicates that these immunomodulatory actions of antidepressants are most likely unrelated to inhibition of monoamine reuptake.
Negative_regulation (suppressed) of Gene_expression (production) of IFN-gamma in T-cell associated with antidepressant and monoamine
3) Confidence 0.56 Published 2006 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 16388933 Disease Relevance 0.22 Pain Relevance 1.09
All of the antidepressants suppressed IFN-gamma production in the 10-50 microM concentration range, irrespective of their preference for serotonin or noradrenaline transporters.
Negative_regulation (suppressed) of Gene_expression (production) of IFN-gamma associated with antidepressant, noradrenaline and serotonin
4) Confidence 0.56 Published 2006 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 16388933 Disease Relevance 0.27 Pain Relevance 0.98
Similar to the results obtained after 24 h, IFN-gamma production after 96 h was biphasically inhibited by salmeterol, and this inhibition (60%) was significantly at 10(-5) M.
Negative_regulation (inhibited) of Gene_expression (production) of IFN-gamma
5) Confidence 0.55 Published 1996 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8796447 Disease Relevance 0 Pain Relevance 0.27
Salmeterol inhibits interferon-gamma and interleukin-4 production by human peripheral blood mononuclear cells.
Negative_regulation (inhibits) of Gene_expression (production) of interferon-gamma in mononuclear cells
6) Confidence 0.55 Published 1996 Journal Int. J. Immunopharmacol. Section Title Doc Link 8796447 Disease Relevance 0.10 Pain Relevance 0.12
Furthermore, tenidap was found to inhibit IFN-gamma production as well as the induction of mRNA encoding IFN-gamma or TNF-alpha.
Negative_regulation (inhibit) of Gene_expression (production) of IFN-gamma
7) Confidence 0.53 Published 1995 Journal Scand. J. Immunol. Section Abstract Doc Link 8552993 Disease Relevance 0.57 Pain Relevance 0.50
Recent studies have shown that in vitro exposure of peripheral blood mononuclear cells (PBMC) to morphine results in suppressed respiratory-burst activity of monocytes and impaired interferon-gamma (IFN-gamma) production by lymphocytes.
Negative_regulation (impaired) of in mononuclear cells Gene_expression (production) of IFN-gamma in respiratory associated with morphine
8) Confidence 0.43 Published 1989 Journal J. Infect. Dis. Section Abstract Doc Link 2536791 Disease Relevance 0 Pain Relevance 0.54
In contrast to their effects in human PBL, the drugs even inhibited the production of IFN-gamma after stimulation with PHA or Con A.
Negative_regulation (inhibited) of Gene_expression (production) of IFN-gamma in PBL
9) Confidence 0.42 Published 1992 Journal Arch. Immunol. Ther. Exp. (Warsz.) Section Abstract Doc Link 1284366 Disease Relevance 0.54 Pain Relevance 0.19
Antidepressants suppress production of the Th1 cytokine interferon-gamma, independent of monoamine transporter blockade.
Negative_regulation (suppress) of Gene_expression (production) of interferon-gamma associated with antidepressant, monoamine and cytokine
10) Confidence 0.41 Published 2006 Journal Eur Neuropsychopharmacol Section Title Doc Link 16388933 Disease Relevance 0.24 Pain Relevance 0.97
This suppression of IFN-gamma production was paralleled by reduced T-cell proliferation, therefore we suggest that the ability of antidepressants to suppress IFN-gamma production may be related to their anti-proliferative properties.
Negative_regulation (suppression) of Gene_expression (production) of IFN-gamma in T-cell associated with antidepressant
11) Confidence 0.41 Published 2006 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 16388933 Disease Relevance 0.25 Pain Relevance 1.01
A biphasic concentration response curve was observed for the inhibitory activity of all beta-adrenoceptor agonists on IFN-gamma production by PBMC 24 h after PHA activation.
Negative_regulation (activity) of Gene_expression (production) of IFN-gamma in PBMC associated with agonist
12) Confidence 0.40 Published 1996 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8796447 Disease Relevance 0.06 Pain Relevance 0.16
Interestingly, treatment with COX-2-specific inhibitors such as NS398 or Celecoxib severely diminished early and late events of T cell activation, including CD25 and CD71 cell surface expression, IL-2, TNF-alpha, and IFN-gamma production and cell proliferation, but not the expression of CD69, an immediate early gene.
Negative_regulation (diminished) of Gene_expression (production) of IFN-gamma in T cell
13) Confidence 0.22 Published 1999 Journal J. Immunol. Section Abstract Doc Link 10384106 Disease Relevance 0.15 Pain Relevance 0.23
At pharmacologically attainable concentrations, INF, but not IND, suppressed the production of IgM and IgG of B cells, whereas neither suppressed the T cell proliferation and IFN-gamma production.
Neg (neither) Negative_regulation (suppressed) of Gene_expression (production) of IFN-gamma in T cell
14) Confidence 0.22 Published 1999 Journal Immunopharmacology Section Abstract Doc Link 10598881 Disease Relevance 0.30 Pain Relevance 0.18
In contrast, neutralization of endogenous IL-22 activity by IL-22-binding protein decreased IL-4, IL-13 and IFN-gamma synthesis [270].
Negative_regulation (decreased) of Gene_expression (synthesis) of IFN-gamma
15) Confidence 0.17 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.85 Pain Relevance 0.26
They suppressed IFN-gamma production and proliferation by CD4+ T cells in vitro in a cell contact-dependent manner, which could be blocked using a CTLA-4-specific mAb.
Negative_regulation (suppressed) of Gene_expression (production) of IFN-gamma in T cells
16) Confidence 0.15 Published 2005 Journal Eur. J. Immunol. Section Abstract Doc Link 16180249 Disease Relevance 0.23 Pain Relevance 0.13
The results demonstrated a significant decrease in interferon-gamma production and an increase in interleukin-10 secretion in heroin addicts, relative to the control group (35.9+/-26.3 versus 110.2+/-60.3 pg/mL, p<0.01 and 71.8+/-28.4 versus 17.1+/-13.5 pg/mL, p<0.01, respectively), however the changes in these values in opium addicts were not significant compared to healthy individuals.
Negative_regulation (decrease) of Gene_expression (production) of interferon-gamma
17) Confidence 0.09 Published 2007 Journal Eur. Cytokine Netw. Section Abstract Doc Link 17993452 Disease Relevance 0.16 Pain Relevance 0.64
An altered Th1/Th2 balance, characterized by reduced IL-4, IFN-gamma and TNF-alpha but normal IL-2 levels, was present in untreated heroin addicted subjects, while the Th1/Th2 balance was well conserved in the methadone and buprenorphine groups.
Negative_regulation (reduced) of Gene_expression (levels) of IFN-gamma associated with methadone and buprenorphine
18) Confidence 0.07 Published 2008 Journal Brain Behav. Immun. Section Abstract Doc Link 18294814 Disease Relevance 0.23 Pain Relevance 1.23
Conversely, the stimulated monocytic IL-12 and lymphocytic IL-10 expression were reduced in IBS and FD, while IFN-gamma expression was also reduced in FD patients.
Negative_regulation (reduced) of Gene_expression (expression) of IFN-gamma associated with spastic colon and nud
19) Confidence 0.07 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19126184 Disease Relevance 1.41 Pain Relevance 0.98
Some of the patients suffered also from atopic dermatitis (AD) and were exposed to cat and/or other pet allergens, associated with an increased IL-4 and decreased IFN-gamma production.
Negative_regulation (decreased) of Gene_expression (production) of IFN-gamma associated with eczema
20) Confidence 0.05 Published 2007 Journal Am J Ther Section Abstract Doc Link 17303977 Disease Relevance 1.50 Pain Relevance 0.61

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