INT50581

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Context Info
Confidence 0.55
First Reported 1995
Last Reported 2010
Negated 6
Speculated 1
Reported most in Abstract
Documents 26
Total Number 27
Disease Relevance 8.96
Pain Relevance 4.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (PPIG) protein folding (PPIG) nucleoplasm (PPIG)
nucleolus (PPIG) nucleus (PPIG) cytoplasm (PPIG)
Anatomy Link Frequency
liver 3
plasma 2
hepatocytes 2
ECs 1
endothelium 1
PPIG (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 70 100.00 Very High Very High Very High
antagonist 25 100.00 Very High Very High Very High
Analgesic 10 100.00 Very High Very High Very High
Buprenorphine 6 100.00 Very High Very High Very High
methadone 5 99.70 Very High Very High Very High
aspirin 7 98.68 Very High Very High Very High
cINOD 11 98.40 Very High Very High Very High
fluoxetine 4 98.26 Very High Very High Very High
lidocaine 17 98.24 Very High Very High Very High
Oxycodone 3 98.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 372 99.88 Very High Very High Very High
Burns 5 99.64 Very High Very High Very High
Cancer 132 99.52 Very High Very High Very High
Sepsis 8 99.50 Very High Very High Very High
Disease 19 99.06 Very High Very High Very High
INFLAMMATION 93 98.20 Very High Very High Very High
Endometriosis (extended) 4 98.12 Very High Very High Very High
Infection 3 97.12 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 3 96.68 Very High Very High Very High
Immunodeficiency 1 96.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this "dual-activity" system, alamethicin, a pore-forming peptide, was used to activate UGTs in human liver microsomes without affecting CYP activity.
Neg (without) Regulation (affecting) of CYP in liver
1) Confidence 0.55 Published 2003 Journal Eur J Drug Metab Pharmacokinet Section Abstract Doc Link 14527096 Disease Relevance 0 Pain Relevance 0.09
Similarly, although inhibitory effects of the smoke constituents carbon monoxide and cadmium on CYP enzymes have been observed in vitro and in animal studies, the relevance of this inhibition to humans has not yet been established.
Regulation (effects) of CYP
2) Confidence 0.44 Published 1999 Journal Clin Pharmacokinet Section Abstract Doc Link 10427467 Disease Relevance 0.81 Pain Relevance 0.11
We report the effect of a known cytochrome P450 (CYP) inducer, rifampicin, on the metabolism of lidocaine by primary human hepatocytes.
Regulation (effect) of CYP in hepatocytes associated with lidocaine
3) Confidence 0.41 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7636727 Disease Relevance 0 Pain Relevance 0.32
It has been established that human cytochrome P450 (CYP) enzymatic activity is affected by gender, or by hormonal factors such as the menopause in women.
Regulation (affected) of CYP associated with endometriosis (extended)
4) Confidence 0.41 Published 2005 Journal Eur J Drug Metab Pharmacokinet Section Abstract Doc Link 16435566 Disease Relevance 0.44 Pain Relevance 0.34
Acetylsalicylic acid (aspirin) and the naturally occurring phytochemical salicylic acid had no effect on CYP activity.
Neg (no) Regulation (effect) of CYP associated with aspirin
5) Confidence 0.32 Published 2004 Journal Cancer Res. Section Abstract Doc Link 14729655 Disease Relevance 0.16 Pain Relevance 0.27
Evidence obtained from the effects of cytochrome P450 (CYP) inhibitors on the demethylation of LAAM to norLAAM by placental microsomes suggested that CYP 19/aromatase is the major enzyme involved.
Regulation (effects) of CYP
6) Confidence 0.28 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15104241 Disease Relevance 0 Pain Relevance 0.15
Fluoxetine is a substantial inhibitor of CYP2D6, has mild effects on CYP3A3/4, and may also have effects on CYP2C9/10 and CYP2C19.
Regulation (effects) of CYP associated with fluoxetine
7) Confidence 0.26 Published 1996 Journal Int Clin Psychopharmacol Section Abstract Doc Link 9032002 Disease Relevance 0.12 Pain Relevance 0.30
Reboxetine at therapeutic concentrations has no effect on the in vitro activity of CYP1A2, 2C9, 2D6, 2E1 or 3A4.
Neg (no) Regulation (effect) of CYP
8) Confidence 0.26 Published 2000 Journal Clin Pharmacokinet Section Abstract Doc Link 11192474 Disease Relevance 0.15 Pain Relevance 0.18
Methadone metabolism is affected by cytochrome P450 (CYP) 3A4 inhibitors or inducers.
Regulation (affected) of CYP associated with methadone
9) Confidence 0.24 Published 2000 Journal Pharmacotherapy Section Abstract Doc Link 10641980 Disease Relevance 0.47 Pain Relevance 0.45
In this study, the effects of hydrocotarnine on the cytochrome P450 (CYP) and P-glycoprotein (P-gp) were investigated.
Regulation (effects) of CYP
10) Confidence 0.17 Published 2009 Journal Drug Metab. Pharmacokinet. Section Abstract Doc Link 19252340 Disease Relevance 0 Pain Relevance 0.29
The levels of other CYP proteins, including CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP2E1, were not affected by eletriptan.
Neg (not) Regulation (affected) of CYP
11) Confidence 0.17 Published 2000 Journal Drug Metab. Dispos. Section Abstract Doc Link 10611140 Disease Relevance 0.06 Pain Relevance 0.16
BACKGROUND: Potential drug-drug interactions can be identified in vitro by exploring the importance of specific cytochrome P450 (CYP) isozymes for drug metabolism.
Regulation (importance) of CYP
12) Confidence 0.16 Published 1998 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 9834040 Disease Relevance 0 Pain Relevance 0.10
We studied the human cytochrome P450 (CYP) isoform responsible for indomethacin O-demethylation, the major metabolic pathway for indomethacin.
Regulation (responsible) of CYP
13) Confidence 0.11 Published 1998 Journal Drug Metab. Dispos. Section Abstract Doc Link 9492390 Disease Relevance 0.10 Pain Relevance 0.10
Two aspects have been particularly taken into account: the changes or absence of changes in plasma/serum concentrations of concomitant drugs and the direct or indirect evidence of induction, inhibition or lack of effect on the six major human hepatic CYP isozymes (CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4), as well as on other CYP isozymes or enzyme systems.
Regulation (effect) of CYP in plasma
14) Confidence 0.08 Published 2000 Journal Fundam Clin Pharmacol Section Abstract Doc Link 11030437 Disease Relevance 0 Pain Relevance 0.20
The effects of buprenorphine, a powerful mixed agonist/antagonist analgesic, on several cytochrome P450 (CYP) isoform specific reactions in human liver microsomes were investigated to predict drug interaction of buprenorphine in vivo from in vitro data.
Spec (investigated) Regulation (effects) of CYP in liver associated with analgesic, antagonist, agonist and buprenorphine
15) Confidence 0.07 Published 2002 Journal Biol. Pharm. Bull. Section Abstract Doc Link 12033517 Disease Relevance 0 Pain Relevance 0.52
Two aspects have been particularly taken into account: the changes or absence of changes in plasma/serum concentrations of concomitant drugs and the direct or indirect evidence of induction, inhibition or lack of effect on the six major human hepatic CYP isozymes (CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4), as well as on other CYP isozymes or enzyme systems.
Regulation (effect) of CYP in plasma
16) Confidence 0.07 Published 2000 Journal Fundam Clin Pharmacol Section Abstract Doc Link 11030437 Disease Relevance 0 Pain Relevance 0.20
Interestingly, these inhibitors had no effect on EETs in the tumor tissue suggesting that the tumor endothelium may be the target of these CYP inhibitors [124].
Regulation (target) of CYP in endothelium associated with cancer
17) Confidence 0.03 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 1.41 Pain Relevance 0.09
There is growing evidence that specific disease states such as sepsis, burns, and trauma also influence CYP and transporter activity, independent of whether AKI is also present.
Regulation (influence) of CYP associated with burns, injury, disease and sepsis
18) Confidence 0.03 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 1.46 Pain Relevance 0.13
Another important consideration regarding the effect of AKI on drug metabolism is that an observed change in CYP activity in a particular organ cannot be extrapolated to other organs.
Regulation (change) of CYP associated with injury
19) Confidence 0.03 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 1.29 Pain Relevance 0
Okabe and coworkers [24] demonstrated that the change in CYP activity in the intestine and liver may not necessarily be the same.
Regulation (change) of CYP in intestine
20) Confidence 0.03 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 1.13 Pain Relevance 0

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