INT5059

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Context Info
Confidence 0.70
First Reported 1989
Last Reported 2011
Negated 39
Speculated 18
Reported most in Abstract
Documents 1050
Total Number 1068
Disease Relevance 896.51
Pain Relevance 322.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
macrophages 34
T cells 28
monocytes 22
plasma 17
lymphocytes 13
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 16584 100.00 Very High Very High Very High
cytokine 13323 100.00 Very High Very High Very High
rheumatoid arthritis 8765 100.00 Very High Very High Very High
Arthritis 3535 100.00 Very High Very High Very High
Infliximab 3284 100.00 Very High Very High Very High
Etanercept 2031 100.00 Very High Very High Very High
Inflammatory response 1719 100.00 Very High Very High Very High
methotrexate 1265 100.00 Very High Very High Very High
chemokine 1219 100.00 Very High Very High Very High
antagonist 981 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 18947 100.00 Very High Very High Very High
Disease 10596 100.00 Very High Very High Very High
Rheumatoid Arthritis 9248 100.00 Very High Very High Very High
Cancer 6199 100.00 Very High Very High Very High
Apoptosis 4925 100.00 Very High Very High Very High
Infection 4888 100.00 Very High Very High Very High
Obesity 4470 100.00 Very High Very High Very High
Stress 2392 100.00 Very High Very High Very High
Necrosis 2162 100.00 Very High Very High Very High
Death 2106 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ANOVA revealed that TNF-alpha levels increased during the eluate sampling period.
Positive_regulation (increased) of TNF-alpha
1) Confidence 0.70 Published 2010 Journal Exp. Neurol. Section Abstract Doc Link 19931249 Disease Relevance 0.37 Pain Relevance 0.57
Experimental and preliminary clinical data have shown that circulating levels of TNFalpha are increased during cardiac graft rejection, and indicate that TNFalpha plays a role in the pathogenesis of acute cardiac allograft rejection.
Positive_regulation (increased) of TNFalpha associated with graft vs host disease
2) Confidence 0.70 Published 2005 Journal BioDrugs Section Abstract Doc Link 16128605 Disease Relevance 0.84 Pain Relevance 0.23
Exogenous prostaglandin E(2) (IC(50)<5 nM) inhibited endotoxin-induced TNFalpha mRNA and protein while, up to 1 microM, it did not significantly affect cyclooxygenase-2 mRNA expression.
Positive_regulation (induced) of TNFalpha
3) Confidence 0.70 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464057 Disease Relevance 0.18 Pain Relevance 0.15
Consistent with downregulation of bone-resorbing mediators, eugenol suppressed the messenger RNA expression of LPS-induced IL-1beta, TNF-alpha, and cyclooxygenase-2 in macrophages.
Positive_regulation (induced) of TNF-alpha in macrophages
4) Confidence 0.70 Published 2007 Journal J Endod Section Abstract Doc Link 17509409 Disease Relevance 0.32 Pain Relevance 0.22
Elevated TNF-alpha levels in the culture medium were reliably detected at 360 minutes after exposure to LPS.
Positive_regulation (Elevated) of TNF-alpha
5) Confidence 0.69 Published 2000 Journal Am Surg Section Abstract Doc Link 11261622 Disease Relevance 0.42 Pain Relevance 0.16
In TB patients, peripheral increases in TNF have been implicated in clinical worsening [10].
Positive_regulation (increases) of TNF associated with mycobacterial infection
6) Confidence 0.69 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2041971 Disease Relevance 1.81 Pain Relevance 0.26
Although TNF-alpha has been found in human HD, it is not known whether TNF-alpha concentrations are increased in symptomatic patients.
Spec (whether) Positive_regulation (increased) of TNF-alpha
7) Confidence 0.69 Published 2008 Journal Spine Section Body Doc Link 18758358 Disease Relevance 0 Pain Relevance 0
Systemic administration of iloprost inhibited serum TNF levels after intraperitoneal LPS, whereas intracerebroventricular injection of iloprost or PGE2 did not inhibit brain TNF induced by intracerebroventricular LPS.
Positive_regulation (induced) of TNF in brain associated with intracerebroventricular
8) Confidence 0.69 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9798931 Disease Relevance 0.67 Pain Relevance 0.68
Intoxication with different natural toxins or man-made toxicants has been associated with the induction of tumor necrosis factor alpha (TNF).
Positive_regulation (induction) of TNF associated with necrosis, cancer and poisoning
9) Confidence 0.69 Published 1999 Journal Toxicology Section Abstract Doc Link 10576587 Disease Relevance 0.54 Pain Relevance 0.09
Intoxication with different natural toxins or man-made toxicants has been associated with the induction of tumor necrosis factor alpha (TNF).
Positive_regulation (induction) of tumor necrosis factor alpha associated with necrosis, cancer and poisoning
10) Confidence 0.69 Published 1999 Journal Toxicology Section Abstract Doc Link 10576587 Disease Relevance 0.54 Pain Relevance 0.08
Increased TNF-alpha levels have been observed not only in cancer patients but also in cachectic patients with the acquired immunodeficiency syndrome (AIDS), and TNF-alpha is known to increase the expression of the human immunodeficiency virus type 1 (HIV-1) via activating its long terminal repeat (LTR).
Positive_regulation (Increased) of TNF-alpha associated with syndrome, cancer, acquired immune deficiency syndrome or hiv infection and immunodeficiency
11) Confidence 0.68 Published 1991 Journal Blood Section Abstract Doc Link 1707692 Disease Relevance 1.09 Pain Relevance 0.09
This raises the question of the contribution of monocytes to the increased TNF-?
Positive_regulation (increased) of TNF in monocytes
12) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297564 Disease Relevance 0.92 Pain Relevance 0.40
In addition, they were found to increase their TNF-?
Positive_regulation (increase) of TNF
13) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297564 Disease Relevance 0.60 Pain Relevance 0.33
This result indicates that synovial cell populations are indeed likely to be the major source of the increased TNF-?
Positive_regulation (increased) of TNF in synovial cell
14) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297564 Disease Relevance 0.50 Pain Relevance 0.25
in RA, T cell-dependent induction of TNF-?
Positive_regulation (induction) of TNF in T cell associated with rheumatoid arthritis
15) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1297564 Disease Relevance 0.58 Pain Relevance 0.29
As seen in Fig. 2a, co-incubation of monocytes of patients with RA with preactivated fixed T cells resulted in significantly lower levels of TNF-?
Positive_regulation (resulted) of TNF in monocytes associated with rheumatoid arthritis
16) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297564 Disease Relevance 0.81 Pain Relevance 0.41
The induction of TNF-?
Positive_regulation (induction) of TNF
17) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297564 Disease Relevance 0.72 Pain Relevance 0.43
In patients positive for human immunodeficiency virus (HIV), HIV-RNA levels have been correlated with elevated tumor necrosis factor-alpha (TNF-alpha) levels.
Positive_regulation (elevated) of TNF-alpha associated with necrosis, cancer and acquired immune deficiency syndrome or hiv infection
18) Confidence 0.68 Published 2003 Journal J. Rheumatol. Section Abstract Doc Link 12563704 Disease Relevance 1.63 Pain Relevance 0.47
In patients positive for human immunodeficiency virus (HIV), HIV-RNA levels have been correlated with elevated tumor necrosis factor-alpha (TNF-alpha) levels.
Positive_regulation (elevated) of tumor necrosis factor-alpha associated with necrosis, cancer and acquired immune deficiency syndrome or hiv infection
19) Confidence 0.68 Published 2003 Journal J. Rheumatol. Section Abstract Doc Link 12563704 Disease Relevance 1.62 Pain Relevance 0.46
This was shown by increased TNF?
Positive_regulation (increased) of TNF
20) Confidence 0.68 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564801 Disease Relevance 0.42 Pain Relevance 0.20

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