INT50616

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Context Info
Confidence 0.49
First Reported 1995
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.72
Pain Relevance 3.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fos) DNA binding (Fos) transcription factor binding (Fos)
Anatomy Link Frequency
striatum 4
spinal 2
NAcS 2
neural 2
Fos (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 15 99.72 Very High Very High Very High
Nucleus accumbens 11 99.68 Very High Very High Very High
Nerve growth factor 7 99.68 Very High Very High Very High
Periaqueductal grey 1 99.12 Very High Very High Very High
Dopamine 153 97.84 Very High Very High Very High
Morphine 7 97.52 Very High Very High Very High
Ventral tegmentum 11 96.08 Very High Very High Very High
Opioid 1 94.68 High High
antagonist 14 94.40 High High
gABA 9 93.48 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 2 99.12 Very High Very High Very High
Targeted Disruption 13 89.28 High High
Myalgia 1 72.64 Quite High
Nociception 2 71.28 Quite High
Headache 2 69.00 Quite High
Aids-related Complex 10 67.68 Quite High
Disease 19 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 16 5.00 Very Low Very Low Very Low
Diabetes Mellitus 11 5.00 Very Low Very Low Very Low
Sprains And Strains 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We then assessed whether activation of the GLP-1Rc was essential for regulation of the neural c-Fos expression pattern observed in response to the activation of enteric glucose sensor.
Spec (whether) Positive_regulation (essential) of Regulation (regulation) of c-Fos in neural
1) Confidence 0.49 Published 2008 Journal Diabetes Section Body Doc Link PMC2551668 Disease Relevance 0.31 Pain Relevance 0.04
By day 21, as in adult animals, no more c-fos response to D1 agonists was observed, except in the most caudal division of the striatum.
Neg (no) Positive_regulation (more) of Neg (no) Regulation (response) of c-fos in striatum associated with agonist
2) Confidence 0.45 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7637573 Disease Relevance 0 Pain Relevance 0.40
In comparison with sham and saline conditions, NGF administration induced significantly stronger Fos immunoreactivity in the mesencephalic periaqueductal grey (PAG), the medullary lateral reticular nucleus (LRN), and superficial layers I and II of cervical spinal dorsal horns C1, C2 and C3.
Positive_regulation (induced) of Regulation (immunoreactivity) of Fos in spinal associated with nerve growth factor, periaqueductal grey and urological neuroanatomy
3) Confidence 0.44 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16426266 Disease Relevance 0.41 Pain Relevance 0.66
Next, morphine was administered on days 1, 3, 5, and 9 and mice demonstrated sensitization to its motor stimulant effects and concomitant induction of Fos immunoreactivity in the NAc shell (NAcS) but not NAc core.
Positive_regulation (induction) of Regulation (immunoreactivity) of Fos in NAcS associated with nucleus accumbens and morphine
4) Confidence 0.43 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14610238 Disease Relevance 0 Pain Relevance 1.84
Pharmacological studies show that Fos immunoreactivity in the striatum and other key regions of
   the brain is increased following administration of D1 and D2 agonists 58, 66, 69, 109, 126, suggesting Fos may be important as a downstream gene regulated by dopaminergic
   signaling. ?
Positive_regulation (increased) of Regulation (immunoreactivity) of Fos in striatum associated with agonist
5) Confidence 0.24 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2836544 Disease Relevance 0 Pain Relevance 0.23

General Comments

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