INT50618

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Context Info
Confidence 0.74
First Reported 1995
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 48
Total Number 51
Disease Relevance 17.37
Pain Relevance 15.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Dio1) endoplasmic reticulum (Dio1)
Anatomy Link Frequency
neurons 6
striatum 4
NAc 3
GI-LI-N 2
MSNs 2
Dio1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 1167 100.00 Very High Very High Very High
projection neuron 484 100.00 Very High Very High Very High
substance P 266 100.00 Very High Very High Very High
agonist 128 100.00 Very High Very High Very High
dopamine receptor 95 100.00 Very High Very High Very High
addiction 29 100.00 Very High Very High Very High
Dynorphin 24 100.00 Very High Very High Very High
Nucleus accumbens 82 99.98 Very High Very High Very High
cerebral cortex 36 99.86 Very High Very High Very High
gABA 323 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 381 99.96 Very High Very High Very High
Targeted Disruption 249 99.50 Very High Very High Very High
Skin Cancer 689 99.24 Very High Very High Very High
Body Weight 56 99.12 Very High Very High Very High
Diarrhoea 6 99.08 Very High Very High Very High
Neuroblastoma 611 98.72 Very High Very High Very High
Cancer 724 98.28 Very High Very High Very High
Wrinkles 1 98.12 Very High Very High Very High
Dystonia 13 96.56 Very High Very High Very High
Stress 7 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together, these data demonstrate significant differences in electrophysiological properties of subpopulations of MSSNs defined by selective expression of D1 and D2 receptors.
Gene_expression (expression) of D1
1) Confidence 0.74 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18279319 Disease Relevance 0 Pain Relevance 0.22
The electrophysiological properties of distinct subpopulations of striatal medium-sized spiny neurons (MSSNs) were compared using enhanced green fluorescent protein as a reporter gene for identification of neurons expressing dopamine D1 and D2 receptor subtypes in mice.
Gene_expression (expressing) of D1 in neurons associated with dopamine
2) Confidence 0.65 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18279319 Disease Relevance 0 Pain Relevance 0.19
In the present study, we show that cannabinoid CB1 receptor mRNA is present in striatonigral neurons expressing substance P and dopamine D1 receptors, as well as in striatopallidal neurons expressing enkephalin and dopamine D2 receptors.
Gene_expression (expressing) of D1 in neurons associated with dopamine, cannabinoid, enkephalin and substance p
3) Confidence 0.52 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17957223 Disease Relevance 0 Pain Relevance 0.83
During striatal development, dopamine afferents initially reach the striosomal compartment, and this early dopamine innervation is thought to influence, through the D1 receptors first expressed in the developing patches, the phenotype of target striatal cells.
Gene_expression (expressed) of D1 associated with dopamine
4) Confidence 0.49 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7637573 Disease Relevance 0 Pain Relevance 0.17
Cannabinoid CB1 receptors are densely expressed on striatal projection neurons expressing dopamine D1 or D2 receptors.
Gene_expression (expressing) of D1 in projection neurons associated with dopamine, cannabinoid and projection neuron
5) Confidence 0.45 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17957223 Disease Relevance 0 Pain Relevance 0.50
Despite unaltered expression of D1 and D2 dopamine receptors, there were dramatic alterations in striatal mRNAs encoding the neuropeptides substance P, dynorphin, enkephalin and cholecystokinin.
Gene_expression (expression) of D1 associated with dynorphin, dopamine receptor, neuropeptide, enkephalin, cholecystokinin and substance p
6) Confidence 0.45 Published 2007 Journal Brain Res. Section Abstract Doc Link 17433807 Disease Relevance 0 Pain Relevance 0.60
The effect of AM404 on grooming behavior was absent in dopamine D1 receptor knockout mice, demonstrating its dependence on D1 receptors.
Neg (absent) Gene_expression (dependence) of D1 associated with targeted disruption, addiction and dopamine
7) Confidence 0.45 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17957223 Disease Relevance 0.10 Pain Relevance 0.87
It is concluded that activation of both dopamine D1 and D2 receptors may suppress naloxone-induced jumping in morphine-dependent mice, and that stimulation of dopamine D1 receptors during development of morphine dependence may increase diarrhoea through peripheral mechanism.
Gene_expression (activation) of D1 associated with addiction, dopamine, diarrhoea, narcan and morphine
8) Confidence 0.44 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12242090 Disease Relevance 0.58 Pain Relevance 0.93
It suppresses the expression of cyclin D1, which is deregulated in several types of tumor, and it also induces apoptosis in tumor cells by activating caspase-8, which leads to cleavage of Bid, thus resulting in sequential release of mitochondrial cytochrome c and activation of caspase-9 and caspase-3, cleavage of poly ADP ribose polymerase (PARP) and apoptosis of tumor cells.
Gene_expression (expression) of D1 in poly associated with cancer and apoptosis
9) Confidence 0.41 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 1.04 Pain Relevance 0.08
When 1,1'-dioctadecyl-3,3,3',3'-tetramethyl-indocarbocyanine perchlorate (DiI), a hydrophobic fluorescence probe, was applied in IPM alone, the amount of DiI which penetrated into the intercellular space of the SC was very low, but this was markedly increased when DiI was applied in IPM/GEFA-C(8).
Gene_expression (applied) of DiI
10) Confidence 0.41 Published 2010 Journal Biol. Pharm. Bull. Section Abstract Doc Link 20118556 Disease Relevance 0 Pain Relevance 0.47
D1 and D6 induce apoptosis in both melanoma and neuroblastoma cells
Gene_expression (induce) of D1 associated with neuroblastoma, skin cancer and apoptosis
11) Confidence 0.36 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 1.34 Pain Relevance 0
The pronounced delay in tumor growth, especially by D6, was translated into tumor weight values, which have been obtained at the end of the treatment (Figure 6, panel B: both D1 and D6 vs control, ***, P < 0.001; D6 vs D1, *, P < 0.05).
Gene_expression (control) of D1 associated with cancer
12) Confidence 0.36 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 0.96 Pain Relevance 0.04
All MM (3-5 × 103 per well) and NB (8-12 × 103 per well) cell lines were plated in 96-well plates in complete medium and treated in quadruplicate with different concentrations of either D1/D6 (0-25 ?
Gene_expression (concentrations) of D1 associated with neuroblastoma and skin cancer
13) Confidence 0.36 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 0.66 Pain Relevance 0
All MM (3-5 × 103 per well) and NB (8-12 × 103 per well) cell lines were plated in 96-well plates in complete medium and treated in quadruplicate with different concentrations of either D1/D6 (0-25 ?
Gene_expression (/) of D1 associated with neuroblastoma and skin cancer
14) Confidence 0.36 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 0.66 Pain Relevance 0
On this regard, mean body weight of treated mice was not affected by either D1 or D6 administration and both liver and renal functionality showed to be normal (see Additional file 2 Table S1).
Gene_expression (administration) of D1 in liver associated with body weight
15) Confidence 0.36 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 0.80 Pain Relevance 0
More importantly, the survival rate was significantly increased only by the D6 treatment (Figure 6, panel D: D6 vs control, P = 0.0007; D6 vs D1, P = 0.0169).
Gene_expression (control) of D1
16) Confidence 0.36 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 0.90 Pain Relevance 0.05
The pronounced delay in tumor growth, especially by D6, was translated into tumor weight values, which have been obtained at the end of the treatment (Figure 6, panel B: both D1 and D6 vs control, ***, P < 0.001; D6 vs D1, *, P < 0.05).
Gene_expression (control) of D1 associated with cancer
17) Confidence 0.36 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 0.96 Pain Relevance 0.04
For in vivo experiments, D1 was diluted in a sterile 0.9% (w/v) NaCl solution containing 1.65 mg/ml bovine serum albumin (BSA, Sigma, St.
Gene_expression (diluted) of D1
18) Confidence 0.36 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 0.63 Pain Relevance 0
MM (LB24) and NB (GI-LI-N) cells were suspended at concentrations of 3 × 105 cells/ml, treated with either D1 or D6 (0, 2.5, 5, 10, or 20 ?
Gene_expression (with) of D1 in GI-LI-N associated with neuroblastoma and skin cancer
19) Confidence 0.36 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 0.46 Pain Relevance 0
Caspase 3/7 assays showed that both D1 and D6 (at 10 ?
Gene_expression (showed) of D1
20) Confidence 0.36 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 1.07 Pain Relevance 0

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