INT50631

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Context Info
Confidence 0.43
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 3.00
Pain Relevance 4.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Glul) mitochondrion (Glul) lyase activity (Glul)
Golgi apparatus (Glul) intracellular (Glul) protein complex (Glul)
Anatomy Link Frequency
striatum 4
brain stem 2
internal 2
pallidum 2
Glul (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 70 100.00 Very High Very High Very High
Enkephalin 8 100.00 Very High Very High Very High
narcan 67 99.74 Very High Very High Very High
Morphine 76 99.16 Very High Very High Very High
gABA 28 98.92 Very High Very High Very High
GABAergic 2 98.32 Very High Very High Very High
Raphe 2 98.14 Very High Very High Very High
mu opioid receptor 97 95.12 Very High Very High Very High
Pain 3 91.48 High High
antagonist 48 90.96 High High
Disease Link Frequency Relevance Heat
Catalepsy 24 100.00 Very High Very High Very High
Diabetes Mellitus 71 99.98 Very High Very High Very High
Pain 6 91.48 High High
Stress 64 80.80 Quite High
Injury 17 80.20 Quite High
Neuropathic Pain 6 75.00 Quite High
Cancer 22 62.88 Quite High
Ganglion Cysts 14 49.88 Quite Low
Drug Induced Neurotoxicity 7 45.32 Quite Low
Hyperalgesia 3 36.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cannabidiol prevents diabetes-induced glutamine synthetase nitration and restores its activity
Positive_regulation (induced) of Gene_expression (nitration) of glutamine synthetase associated with diabetes mellitus
1) Confidence 0.43 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2925907 Disease Relevance 1.04 Pain Relevance 0.04
In contrast, scopolamine was not able to block increased glutamate decarboxylase and enkephalin messenger RNA expression induced by haloperidol in the striatum.
Positive_regulation (induced) of Gene_expression (expression) of glutamate decarboxylase in striatum associated with glutamate and enkephalin
2) Confidence 0.29 Published 1995 Journal Neuroscience Section Abstract Doc Link 7637876 Disease Relevance 0.46 Pain Relevance 0.50
In contrast, scopolamine was not able to block increased glutamate decarboxylase and enkephalin messenger RNA expression induced by haloperidol in the striatum.
Positive_regulation (induced) of Gene_expression (expression) of glutamate decarboxylase in striatum associated with glutamate and enkephalin
3) Confidence 0.21 Published 1995 Journal Neuroscience Section Abstract Doc Link 7637876 Disease Relevance 0.46 Pain Relevance 0.50
Levels of glutamate decarboxylase messenger RNA were also increased in the entopeduncular nucleus (internal pallidum), but only after 14 days of treatment with haloperidol.
Positive_regulation (increased) of Gene_expression (Levels) of glutamate decarboxylase in internal associated with glutamate
4) Confidence 0.19 Published 1995 Journal Neuroscience Section Abstract Doc Link 7637876 Disease Relevance 0.42 Pain Relevance 0.35
We have investigated the effects of neuroleptic treatments which do, or do not, induce catalepsy on the level of expression of glutamate decarboxylase, the rate limiting enzyme in GABA synthesis, in efferent neurons of the pallidum in adult rats.
Neg (not) Positive_regulation (induce) of Gene_expression (expression) of glutamate decarboxylase in pallidum associated with gaba, glutamate and catalepsy
5) Confidence 0.19 Published 1995 Journal Neuroscience Section Abstract Doc Link 7637876 Disease Relevance 0.25 Pain Relevance 0.21
The effect of L-DOPA on the gene expression of preproenkephalin and glutamate decarboxylase (M(r) 67,000) differs from the increase in striatal enkephalin content and glutamate decarboxylase activity previously found following L-DOPA treatment.
Positive_regulation (increase) of Gene_expression (activity) of glutamate decarboxylase associated with glutamate and enkephalin
6) Confidence 0.18 Published 1995 Journal Neuroscience Section Abstract Doc Link 7637869 Disease Relevance 0 Pain Relevance 0.38
Like normal FS cells, Tpit/F1 cells express nNOS and FGF-2 and respond to PACAP (blunting of IL-6 secretion) and glucocorticoids stimulate glutamine synthase expression (661).
Positive_regulation (stimulate) of Gene_expression (expression) of glutamine synthase
7) Confidence 0.07 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.14 Pain Relevance 0
Similar to the blockade by a 100 pM concentration of the active isomer of NLX seen in Fig. 2, 100 pM (+)NLX blocked the Gs coupling induced by 15 min of 100 ┬ÁM morphine (Fig. 3).


Positive_regulation (induced) of Gene_expression (coupling) of Gs associated with narcan and morphine
8) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.74
The neuronal cell line, RN33B, derived from E13 brain stem raphe and immortalized with the SV40 temperature-sensitive allele of large T antigen (tsTag), was transfected with rat GAD67 cDNA (glutamate decarboxylase, the synthetic enzyme for GABA), and the GABAergic cell line, 33G10.17, was isolated.
Positive_regulation (transfected) of Gene_expression (transfected) of glutamate decarboxylase in brain stem associated with gaba, glutamate, gabaergic and raphe
9) Confidence 0.05 Published 1999 Journal Cell Transplant Section Abstract Doc Link 10338278 Disease Relevance 0.22 Pain Relevance 0.65

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