INT50633

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Context Info
Confidence 0.60
First Reported 1993
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 12
Total Number 15
Disease Relevance 1.64
Pain Relevance 6.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Glul) mitochondrion (Glul) lyase activity (Glul)
Golgi apparatus (Glul) intracellular (Glul) protein complex (Glul)
Anatomy Link Frequency
striatum 5
astrocytes 4
spinal 2
NAc 2
spinal cord 2
Glul (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 86 100.00 Very High Very High Very High
Morphine 57 100.00 Very High Very High Very High
Spinal cord 14 100.00 Very High Very High Very High
Gabapentin 6 100.00 Very High Very High Very High
tolerance 6 100.00 Very High Very High Very High
dexamethasone 6 100.00 Very High Very High Very High
Clonidine 2 100.00 Very High Very High Very High
anticonvulsant 2 100.00 Very High Very High Very High
intrathecal 2 100.00 Very High Very High Very High
Enkephalin 8 99.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoxia 128 98.88 Very High Very High Very High
Neurological Disease 8 93.08 High High
Death 9 91.28 High High
Gliosis 1 90.56 High High
Stress 68 76.56 Quite High
Adenoma 5 64.36 Quite High
Morphine Dependence 2 56.84 Quite High
Drug Dependence 6 53.08 Quite High
Bordatella Infection 2 52.60 Quite High
Reperfusion Injury 4 49.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this paper, we have proven that despite the fact that several previous proteome/morphinome studies have indicated changes in glutamine synthetase expression or quantity in cells/tissues/organisms, we did not observe any significant changes in enzyme activity during our experiments.
Regulation (changes) of Gene_expression (expression) of glutamine synthetase
1) Confidence 0.60 Published 2010 Journal Anal Bioanal Chem Section Body Doc Link PMC2990007 Disease Relevance 0 Pain Relevance 0.21
The fact that changes in glutamine synthetase expression were linked to morphine administration by three different methods (isotope-coded affinity tags, (ICAT), 2D gel electrophoresis and Western blot) in four distinct laboratories seems very appealing: It indicates that quantitative changes occur in this enzyme during morphine uptake.
Regulation (changes) of Gene_expression (expression) of glutamine synthetase associated with morphine
2) Confidence 0.60 Published 2010 Journal Anal Bioanal Chem Section Body Doc Link PMC2990007 Disease Relevance 0.11 Pain Relevance 0.65
We studied in vitro the effects of anticonvulsant drugs Gabapentin and Topiramate on the production of reactive oxygen species and nitric oxide (NO), the activity of glutamine synthetase (GS), and cell viability in primary cultures of rat cortical astrocytes which are intimately involved in the normal functioning of neurons.
Regulation (effects) of Gene_expression (production) of glutamine synthetase in astrocytes associated with anticonvulsant and gabapentin
3) Confidence 0.45 Published 2001 Journal Neuroreport Section Abstract Doc Link 11409743 Disease Relevance 0.07 Pain Relevance 0.30
We studied in vitro the effects of anticonvulsant drugs Gabapentin and Topiramate on the production of reactive oxygen species and nitric oxide (NO), the activity of glutamine synthetase (GS), and cell viability in primary cultures of rat cortical astrocytes which are intimately involved in the normal functioning of neurons.
Regulation (effects) of Gene_expression (production) of GS in astrocytes associated with anticonvulsant and gabapentin
4) Confidence 0.45 Published 2001 Journal Neuroreport Section Abstract Doc Link 11409743 Disease Relevance 0.07 Pain Relevance 0.30
[Effects of clonidine on myocardial Gs alpha mRNA expression after scalds in rats].
Regulation (Effects) of Gene_expression (expression) of Gs alpha mRNA associated with clonidine
5) Confidence 0.43 Published 2002 Journal Yao Xue Xue Bao Section Title Doc Link 12579893 Disease Relevance 0 Pain Relevance 0.20
We further examined the effect of intrathecal dexamethasone infusion on the development of morphine tolerance and on expression of the intracellular glutamate metabolizing enzymes, glutamate dehydrogenase and glutamine synthetase, in the spinal cord.
Spec (examined) Regulation (effect) of Gene_expression (expression) of glutamine synthetase in spinal cord associated with glutamate, tolerance, dexamethasone, spinal cord, morphine and intrathecal
6) Confidence 0.43 Published 2007 Journal Anesth. Analg. Section Abstract Doc Link 17312234 Disease Relevance 0 Pain Relevance 1.15
The effect of dexamethasone on spinal glutamine synthetase and glutamate dehydrogenase expression in morphine-tolerant rats.
Regulation (effect) of Gene_expression (expression) of glutamine synthetase in spinal associated with glutamate, dexamethasone and morphine
7) Confidence 0.43 Published 2007 Journal Anesth. Analg. Section Title Doc Link 17312234 Disease Relevance 0 Pain Relevance 1.13
The decreased activity of GS in reperfusion group compared to anoxia may be a cumulative of other factors, including a down regulation of GS production and an increased clearance of this enzyme apart from modulation of GS by NO.
Regulation (regulation) of Gene_expression (production) of GS associated with hypoxia
8) Confidence 0.29 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2880843 Disease Relevance 0.62 Pain Relevance 0.26
The sustained decreased activity of GS in reperfusion group compared to anoxia may be a cumulative of other factors, including a down regulation of GS production and an increased clearance of this enzyme apart from modulation of GS activity by NO.
Regulation (regulation) of Gene_expression (production) of GS associated with hypoxia
9) Confidence 0.29 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2880843 Disease Relevance 0.48 Pain Relevance 0.30
Gene expression of the GAD67 and GAD65 isoforms of glutamate decarboxylase is differentially altered in subpopulations of striatal neurons in adult rats lesioned with 6-OHDA as neonates.
Regulation (altered) of Gene_expression (expression) of glutamate decarboxylase in neurons associated with glutamate and enkephalin
10) Confidence 0.17 Published 1999 Journal Synapse Section Title Doc Link 10380849 Disease Relevance 0 Pain Relevance 0.40
The effect of a unilateral 6-hydroxydopamine lesion of the medial forebrain bundle in rats and subsequent L-DOPA treatment for eight weeks on preproenkephalin, preprotachykinin and glutamate decarboxylase (M(r) 67,000) gene expression in the striatum was investigated by in situ hybridization.
Spec (investigated) Regulation (effect) of in medial forebrain bundle Gene_expression (expression) of glutamate decarboxylase in striatum associated with glutamate
11) Confidence 0.16 Published 1995 Journal Neuroscience Section Abstract Doc Link 7637869 Disease Relevance 0 Pain Relevance 0.13
Chronic L-DOPA treatment differentially regulates gene expression of glutamate decarboxylase, preproenkephalin and preprotachykinin in the striatum of 6-hydroxydopamine-lesioned rat.
Regulation (regulates) of Gene_expression (expression) of glutamate decarboxylase in striatum associated with glutamate and enkephalin
12) Confidence 0.16 Published 1995 Journal Neuroscience Section Title Doc Link 7637869 Disease Relevance 0 Pain Relevance 0.26
The effects of neonatal 6-hydroxydopamine injections on the levels and cellular distribution of glutamate decarboxylase (GAD67), preproenkephalin and dopamine D2 receptor messenger RNAs were studied in the striatum of adult rats.
Regulation (effects) of Gene_expression (levels) of glutamate decarboxylase in striatum associated with dopamine and glutamate
13) Confidence 0.15 Published 1993 Journal Brain Res. Section Abstract Doc Link 7902185 Disease Relevance 0 Pain Relevance 0.27
Similar NAc injections of PTX reduced the level of Gi alpha and G(o) alpha subunits as measured by both ADP-ribosylation and Western blot, without affecting levels of Gs alpha or G beta subunits.
Neg (without) Regulation (affecting) of Gene_expression (levels) of Gs alpha in NAc associated with nucleus accumbens
14) Confidence 0.06 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 7931576 Disease Relevance 0.23 Pain Relevance 0.64
Expression of glutamine synthase is dramatically age-dependent.
Regulation (dependent) of Gene_expression (Expression) of glutamine synthase
15) Confidence 0.03 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.06 Pain Relevance 0.39

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