INT50645

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Context Info
Confidence 0.21
First Reported 1995
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.42
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Glul) mitochondrion (Glul) lyase activity (Glul)
Golgi apparatus (Glul) intracellular (Glul) protein complex (Glul)
Anatomy Link Frequency
internal 2
Glul (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 8 100.00 Very High Very High Very High
mu opioid receptor 97 99.98 Very High Very High Very High
narcan 67 99.66 Very High Very High Very High
Morphine 76 99.52 Very High Very High Very High
gABA 2 86.04 High High
antagonist 6 70.08 Quite High
Opioid 42 67.04 Quite High
addiction 17 63.96 Quite High
tolerance 13 63.36 Quite High
opioid receptor 1 50.52 Quite High
Disease Link Frequency Relevance Heat
Catalepsy 6 99.52 Very High Very High Very High
Opiate Addiction 4 5.00 Very Low Very Low Very Low
Drug Dependence 2 5.00 Very Low Very Low Very Low
Bordatella Infection 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Levels of glutamate decarboxylase messenger RNA were also increased in the entopeduncular nucleus (internal pallidum), but only after 14 days of treatment with haloperidol.
Positive_regulation (increased) of Positive_regulation (increased) of glutamate decarboxylase in internal associated with glutamate
1) Confidence 0.21 Published 1995 Journal Neuroscience Section Abstract Doc Link 7637876 Disease Relevance 0.42 Pain Relevance 0.35
Specifically, FLNA peptide fragments containing the NLX binding site blocked the protective effect of NLX on both the MOR–Gs coupling and downstream cAMP accumulation induced by chronic morphine (twice daily 1-hr exposures for 7 days), presumably by interfering with NLX's binding to FLNA in the tissues.
Positive_regulation (induced) of Positive_regulation (accumulation) of Gs associated with mu opioid receptor, narcan and morphine
2) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.31

General Comments

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