INT50646

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Context Info
Confidence 0.38
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 3.59
Pain Relevance 4.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Glul) mitochondrion (Glul) lyase activity (Glul)
Golgi apparatus (Glul) intracellular (Glul) protein complex (Glul)
Anatomy Link Frequency
globus pallidus 4
Neurons 1
striatum 1
brain 1
hippocampus 1
Glul (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 45 100.00 Very High Very High Very High
Deafferentation 1 99.92 Very High Very High Very High
GABAergic 3 99.64 Very High Very High Very High
Dopamine 49 99.60 Very High Very High Very High
Hippocampus 2 98.80 Very High Very High Very High
cocaine 4 98.60 Very High Very High Very High
antagonist 4 98.00 Very High Very High Very High
tetrodotoxin 2 95.60 Very High Very High Very High
Morphine 9 95.30 Very High Very High Very High
Enkephalin 5 94.92 High High
Disease Link Frequency Relevance Heat
Hepatotoxicity 13 100.00 Very High Very High Very High
Catalepsy 24 99.64 Very High Very High Very High
Generalized Anxiety Disorder 13 95.04 Very High Very High Very High
Necrosis 3 82.04 Quite High
Schizophrenia 2 81.68 Quite High
Disease 8 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Neurological Disease 2 5.00 Very Low Very Low Very Low
Parkinson's Disease 1 5.00 Very Low Very Low Very Low
Repression 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In situ hybridization histochemistry has been used to detect the basal distribution of mRNA encoding the alpha subunit of Gs, Go and Gi2 proteins throughout the rat brain.
Transcription (distribution) of Gs in brain
1) Confidence 0.38 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8458398 Disease Relevance 0 Pain Relevance 0.25
Repeated injections of dizocilpine maleate (MK-801) do not suppress the effects of nigrostriatal dopamine deafferentation on glutamate decarboxylase (GAD67) mRNA expression in the adult rat striatum.
Transcription (expression) of glutamate decarboxylase in striatum associated with glutamate, dopamine and deafferentation
2) Confidence 0.35 Published 1996 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9037536 Disease Relevance 0 Pain Relevance 0.38
The atypical antipsychotic clozapine (seven days, 20 mg/kg, s.c.), which did not induce catalepsy, slightly decreased glutamate decarboxylase messenger RNA levels in the globus pallidus.
Transcription (levels) of glutamate decarboxylase in globus pallidus associated with glutamate and catalepsy
3) Confidence 0.22 Published 1995 Journal Neuroscience Section Abstract Doc Link 7637876 Disease Relevance 0.48 Pain Relevance 0.47
These results reveal a good correlation between increases in glutamate decarboxylase messenger RNA levels in the globus pallidus and catalepsy after these drug treatments and suggest that anticholinergic blockade of the behavioral and molecular effects of neuroleptics may involve non-striatal mechanisms.
Transcription (levels) of glutamate decarboxylase in globus pallidus associated with glutamate and catalepsy
4) Confidence 0.22 Published 1995 Journal Neuroscience Section Abstract Doc Link 7637876 Disease Relevance 0.39 Pain Relevance 0.47
When co-administered with haloperidol (seven days, 1 mg/kg s.c.), the muscarinic antagonist scopolamine (1 mg/kg, s.c.) completely blocked both haloperidol-induced catalepsy and increases in glutamate decarboxylase messenger RNA levels in the globus pallidus.
Transcription (levels) of glutamate decarboxylase in globus pallidus associated with glutamate, catalepsy and antagonist
5) Confidence 0.22 Published 1995 Journal Neuroscience Section Abstract Doc Link 7637876 Disease Relevance 0.47 Pain Relevance 0.50
Different regimens of haloperidol (1 mg/kg s.c., three, seven or 14 days; 2 mg/kg, s.c., 10 days) induced catalepsy in a majority of rats and increased glutamate decarboxylase messenger RNA levels in the globus pallidus (external pallidum) in those rats exhibiting catalepsy.
Transcription (levels) of glutamate decarboxylase in globus pallidus associated with glutamate and catalepsy
6) Confidence 0.22 Published 1995 Journal Neuroscience Section Abstract Doc Link 7637876 Disease Relevance 0.41 Pain Relevance 0.29
It was found that the DCE-Et-GS iPr administration significantly inhibited the GSH depletion caused by APAP, suggesting that the protective effect of DCE-Et-GS iPr on APAP-induced hepatotoxicity was due, at least in part, to the retention of hepatic GSH level.
Transcription (retention) of DCE-Et-GS associated with hepatotoxicity
7) Confidence 0.19 Published 1996 Journal Biol. Pharm. Bull. Section Abstract Doc Link 8889044 Disease Relevance 0.42 Pain Relevance 0.15
It was found that the DCE-Et-GS iPr administration significantly inhibited the GSH depletion caused by APAP, suggesting that the protective effect of DCE-Et-GS iPr on APAP-induced hepatotoxicity was due, at least in part, to the retention of hepatic GSH level.
Transcription (retention) of DCE-Et-GS associated with hepatotoxicity
8) Confidence 0.19 Published 1996 Journal Biol. Pharm. Bull. Section Abstract Doc Link 8889044 Disease Relevance 0.42 Pain Relevance 0.15
It was found that the DCE-Et-GS iPr administration significantly inhibited the GSH depletion caused by APAP, suggesting that the protective effect of DCE-Et-GS iPr on APAP-induced hepatotoxicity was due, at least in part, to the retention of hepatic GSH level.
Transcription (retention) of DCE-Et-GS associated with hepatotoxicity
9) Confidence 0.19 Published 1996 Journal Biol. Pharm. Bull. Section Abstract Doc Link 8889044 Disease Relevance 0.42 Pain Relevance 0.15
Neurons were identified by mRNA expression of choline acetyltransferase (ChAT+, cholinergic) and glutamate decarboxylase (GAD67, GABAergic).
Transcription (expression) of glutamate decarboxylase in Neurons associated with glutamate and gabaergic
10) Confidence 0.18 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15836920 Disease Relevance 0.43 Pain Relevance 0.27
The effects of single (20 or 50 mg/kg) and repeated morphine (14 days, rising doses: four days, 2 x 10 mg/kg; two days, 2 x 20 mg/kg; two days, 2 x 30 mg/kg; two days, 2 x 40 mg/kg and four days, 2 x 50 mg/kg i.p.) or cocaine (20 mg/kg i.p., once every hour for 3 h for one or five days) on the Gs alpha and Go alpha protein messenger RNA levels were investigated in the rat hippocampus.
Transcription (levels) of Gs alpha in hippocampus associated with hippocampus, cocaine and morphine
11) Confidence 0.09 Published 1994 Journal Neuroscience Section Abstract Doc Link 7700512 Disease Relevance 0 Pain Relevance 0.54
Glutamine synthetase (GlnS) mRNA and protein levels were increased in response to SKF (Table 1).
Transcription (levels) of Glutamine synthetase
12) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924890 Disease Relevance 0.16 Pain Relevance 0.46

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