INT50648
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
RESULTS: A subset of patients with IBS (8/19, 42%) had increased intestinal membrane permeability and decreased glutamine synthetase expression compared to patients with IBS normal membrane permeability, and to controls. | |||||||||||||||
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The reduced quantity of Gs alpha mRNA expression level correlated well with the Efa dose (gamma = 0.900, P < 0.05). | |||||||||||||||
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In contrast, scopolamine was not able to block increased glutamate decarboxylase and enkephalin messenger RNA expression induced by haloperidol in the striatum. | |||||||||||||||
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The decreased activity of GS in reperfusion group compared to anoxia may be a cumulative of other factors, including a down regulation of GS production and an increased clearance of this enzyme apart from modulation of GS by NO. | |||||||||||||||
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The sustained decreased activity of GS in reperfusion group compared to anoxia may be a cumulative of other factors, including a down regulation of GS production and an increased clearance of this enzyme apart from modulation of GS activity by NO. | |||||||||||||||
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The atypical antipsychotic clozapine (seven days, 20 mg/kg, s.c.), which did not induce catalepsy, slightly decreased glutamate decarboxylase messenger RNA levels in the globus pallidus. | |||||||||||||||
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Glutamine cysteine ligase and glutathione reductase expression were increased whereas glutamine synthetase expression was decreased (figure 5C, table 3). | |||||||||||||||
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A consequence of reduced GS expression is that the capacity of these astrocytes to detoxify glutamate will be impaired. | |||||||||||||||
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A significant decrease in GS expression was observed in cells treated with EGF in the presence of LIF, TGFß1 or a combination of both, as compared to cells treated with EGF alone (Fig. 4A,B).
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Similar to the blockade by a 100 pM concentration of the active isomer of NLX seen in Fig. 2, 100 pM (+)NLX blocked the Gs coupling induced by 15 min of 100 µM morphine (Fig. 3).
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General Comments
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