INT50648

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Context Info
Confidence 0.58
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 2.70
Pain Relevance 3.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Glul) mitochondrion (Glul) lyase activity (Glul)
Golgi apparatus (Glul) intracellular (Glul) protein complex (Glul)
Anatomy Link Frequency
striatum 2
globus pallidus 2
astrocytes 2
Glul (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 73 100.00 Very High Very High Very High
Enkephalin 2 100.00 Very High Very High Very High
narcan 67 99.98 Very High Very High Very High
Morphine 76 98.84 Very High Very High Very High
mu opioid receptor 97 95.60 Very High Very High Very High
ischemia 18 95.52 Very High Very High Very High
antagonist 17 91.60 High High
Opioid 42 90.48 High High
cytokine 36 86.96 High High
gABA 3 75.20 Quite High
Disease Link Frequency Relevance Heat
Catalepsy 12 99.78 Very High Very High Very High
Hypoxia 146 98.88 Very High Very High Very High
Cv Unclassified Under Development 16 95.52 Very High Very High Very High
Neurological Disease 6 93.08 High High
Death 20 82.48 Quite High
Stress 27 76.56 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

2 76.28 Quite High
Glioblastoma 2 71.68 Quite High
Apoptosis 3 60.04 Quite High
Injury 77 51.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: A subset of patients with IBS (8/19, 42%) had increased intestinal membrane permeability and decreased glutamine synthetase expression compared to patients with IBS normal membrane permeability, and to controls.
Negative_regulation (decreased) of Gene_expression (expression) of glutamine synthetase
1) Confidence 0.58 Published 2010 Journal Gut Section Body Doc Link 19951903 Disease Relevance 0 Pain Relevance 0
The reduced quantity of Gs alpha mRNA expression level correlated well with the Efa dose (gamma = 0.900, P < 0.05).
Negative_regulation (reduced) of Gene_expression (expression) of Gs alpha mRNA
2) Confidence 0.34 Published 2002 Journal Yao Xue Xue Bao Section Body Doc Link 12579893 Disease Relevance 0 Pain Relevance 0
In contrast, scopolamine was not able to block increased glutamate decarboxylase and enkephalin messenger RNA expression induced by haloperidol in the striatum.
Negative_regulation (block) of Gene_expression (expression) of glutamate decarboxylase in striatum associated with glutamate and enkephalin
3) Confidence 0.24 Published 1995 Journal Neuroscience Section Abstract Doc Link 7637876 Disease Relevance 0.46 Pain Relevance 0.50
The decreased activity of GS in reperfusion group compared to anoxia may be a cumulative of other factors, including a down regulation of GS production and an increased clearance of this enzyme apart from modulation of GS by NO.
Negative_regulation (regulation) of Gene_expression (production) of GS associated with hypoxia
4) Confidence 0.21 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2880843 Disease Relevance 0.62 Pain Relevance 0.26
The sustained decreased activity of GS in reperfusion group compared to anoxia may be a cumulative of other factors, including a down regulation of GS production and an increased clearance of this enzyme apart from modulation of GS activity by NO.
Negative_regulation (regulation) of Gene_expression (production) of GS associated with hypoxia
5) Confidence 0.21 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2880843 Disease Relevance 0.48 Pain Relevance 0.30
The atypical antipsychotic clozapine (seven days, 20 mg/kg, s.c.), which did not induce catalepsy, slightly decreased glutamate decarboxylase messenger RNA levels in the globus pallidus.
Negative_regulation (decreased) of Gene_expression (levels) of glutamate decarboxylase in globus pallidus associated with glutamate and catalepsy
6) Confidence 0.18 Published 1995 Journal Neuroscience Section Abstract Doc Link 7637876 Disease Relevance 0.48 Pain Relevance 0.47
Glutamine cysteine ligase and glutathione reductase expression were increased whereas glutamine synthetase expression was decreased (figure 5C, table 3).
Negative_regulation (decreased) of Gene_expression (expression) of glutamine synthetase
7) Confidence 0.13 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2826316 Disease Relevance 0.19 Pain Relevance 0
A consequence of reduced GS expression is that the capacity of these astrocytes to detoxify glutamate will be impaired.
Negative_regulation (reduced) of Gene_expression (expression) of GS in astrocytes associated with glutamate
8) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832687 Disease Relevance 0.40 Pain Relevance 0.14
A significant decrease in GS expression was observed in cells treated with EGF in the presence of LIF, TGFß1 or a combination of both, as compared to cells treated with EGF alone (Fig. 4A,B).


Negative_regulation (decrease) of Gene_expression (expression) of GS
9) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832687 Disease Relevance 0 Pain Relevance 0.11
Similar to the blockade by a 100 pM concentration of the active isomer of NLX seen in Fig. 2, 100 pM (+)NLX blocked the Gs coupling induced by 15 min of 100 µM morphine (Fig. 3).


Negative_regulation (blocked) of Gene_expression (coupling) of Gs associated with narcan and morphine
10) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.74

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