INT50649

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.19
First Reported 1995
Last Reported 1995
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 1.28
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Glul) mitochondrion (Glul) lyase activity (Glul)
Golgi apparatus (Glul) intracellular (Glul) protein complex (Glul)
Anatomy Link Frequency
globus pallidus 6
Glul (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 24 100.00 Very High Very High Very High
antagonist 3 98.26 Very High Very High Very High
Enkephalin 3 95.44 Very High Very High Very High
gABA 3 91.80 High High
Disease Link Frequency Relevance Heat
Catalepsy 18 99.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When co-administered with haloperidol (seven days, 1 mg/kg s.c.), the muscarinic antagonist scopolamine (1 mg/kg, s.c.) completely blocked both haloperidol-induced catalepsy and increases in glutamate decarboxylase messenger RNA levels in the globus pallidus.
Positive_regulation (increases) of Transcription (levels) of glutamate decarboxylase in globus pallidus associated with glutamate, catalepsy and antagonist
1) Confidence 0.19 Published 1995 Journal Neuroscience Section Abstract Doc Link 7637876 Disease Relevance 0.48 Pain Relevance 0.50
These results reveal a good correlation between increases in glutamate decarboxylase messenger RNA levels in the globus pallidus and catalepsy after these drug treatments and suggest that anticholinergic blockade of the behavioral and molecular effects of neuroleptics may involve non-striatal mechanisms.
Positive_regulation (increases) of Transcription (levels) of glutamate decarboxylase in globus pallidus associated with glutamate and catalepsy
2) Confidence 0.19 Published 1995 Journal Neuroscience Section Abstract Doc Link 7637876 Disease Relevance 0.39 Pain Relevance 0.47
Different regimens of haloperidol (1 mg/kg s.c., three, seven or 14 days; 2 mg/kg, s.c., 10 days) induced catalepsy in a majority of rats and increased glutamate decarboxylase messenger RNA levels in the globus pallidus (external pallidum) in those rats exhibiting catalepsy.
Positive_regulation (increased) of Transcription (levels) of glutamate decarboxylase in globus pallidus associated with glutamate and catalepsy
3) Confidence 0.19 Published 1995 Journal Neuroscience Section Abstract Doc Link 7637876 Disease Relevance 0.41 Pain Relevance 0.29

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox