INT50657

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Context Info
Confidence 0.67
First Reported 1994
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 3.95
Pain Relevance 4.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR2B) cytoplasm (HTR2B) signal transducer activity (HTR2B)
Anatomy Link Frequency
blood vessels 1
endothelial cells 1
astrocytes 1
platelets 1
HTR2B (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 13 99.76 Very High Very High Very High
headache 6 99.24 Very High Very High Very High
Rostral ventromedial medulla 8 99.00 Very High Very High Very High
Migraine 22 98.88 Very High Very High Very High
fibrosis 1 98.48 Very High Very High Very High
nMDA receptor 2 98.20 Very High Very High Very High
antagonist 1 97.82 Very High Very High Very High
agonist 5 97.18 Very High Very High Very High
dopamine receptor 1 97.02 Very High Very High Very High
Dopamine 3 94.00 High High
Disease Link Frequency Relevance Heat
Hypertension 1 99.82 Very High Very High Very High
Stress 1 99.82 Very High Very High Very High
INFLAMMATION 14 99.76 Very High Very High Very High
Migraine Disorders 13 99.24 Very High Very High Very High
Adverse Drug Reaction 1 99.14 Very High Very High Very High
Valvular Heart Disease Other Than Mitral Valve Prolapse 1 98.70 Very High Very High Very High
Fibrosis 2 98.48 Very High Very High Very High
Headache 11 97.60 Very High Very High Very High
Cirrhosis 1 96.96 Very High Very High Very High
Variant Angina Pectoris 1 92.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of meningeal 5-HT2B receptors: an early step in the generation of migraine headache?
Positive_regulation (Activation) of 5-HT2B associated with migraine and headache
1) Confidence 0.67 Published 1996 Journal Eur. J. Neurosci. Section Title Doc Link 8743744 Disease Relevance 0.47 Pain Relevance 0.78
Endogenous 5-HT, arising perhaps from platelets but more likely from perivascular 5-HT-containing neurons in response to different types of "stress", would activate 5-HT2B/5-HT2C receptors on endothelial cells of the cerebral vasculature to release NO.
Positive_regulation (activate) of 5-HT2B in platelets associated with stress
2) Confidence 0.49 Published 1995 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 7639613 Disease Relevance 0.43 Pain Relevance 0.49
We first established that 5-HT2B receptors are coupled with the phospholipase A2 (PLA2)-mediated release of arachidonic acid (AA) and that the activation of 5-HT2B receptors in 1C11*d2 cells inhibits the 5-HT1B/1D receptor function via a cyclooxygenase-dependent AA metabolite.
Positive_regulation (activation) of 5-HT2B
3) Confidence 0.49 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9651340 Disease Relevance 0 Pain Relevance 0.05
In this respect, activation of vascular 5-HT2B and/or 5-HT7 receptors, possibly as a consequence of the sudden rise in 5-HT levels reported at the onset of a migraine attack, would hypothetically result in dilation of cerebral blood vessels and concomitant activation of sensory trigeminovascular afferents, hence initiating the manifestation of head pain.
Positive_regulation (activation) of 5-HT2B in blood vessels associated with migraine and headache
4) Confidence 0.49 Published 1999 Journal Can J Neurol Sci Section Abstract Doc Link 10563226 Disease Relevance 0.70 Pain Relevance 0.81
Lisuride, a dopamine receptor agonist with 5-HT2B receptor antagonist properties: absence of cardiac valvulopathy adverse drug reaction reports supports the concept of a crucial role for 5-HT2B receptor agonism in cardiac valvular fibrosis.
Positive_regulation (role) of 5-HT2B associated with adverse drug reaction, fibrosis, valvular heart disease other than mitral valve prolapse, antagonist, dopamine receptor and agonist
5) Confidence 0.49 Published 2006 Journal Clin Neuropharmacol Section Title Doc Link 16614540 Disease Relevance 0.39 Pain Relevance 0.51
Chronic exposure to 5-HT can contribute to pulmonary hypertension through activation of constrictor 5-HT1B receptors and proliferative 5-HT2B receptors, and possibly through direct intracellular effects.
Spec (possibly) Positive_regulation (activation) of 5-HT2B associated with hypertension
6) Confidence 0.49 Published 2006 Journal Pharmacol. Ther. Section Abstract Doc Link 16960982 Disease Relevance 0.73 Pain Relevance 0.23
(Pharmacogenomics J 6:413-420, 2006) and provides the new information that upregulation (1) occurs in astrocytes, (2) is evoked by stimulation of 5-HT(2B) receptor, and (3) requires transactivation-mediated ERK(1/2) phosphorylation.
Positive_regulation (stimulation) of 5-HT(2B) in astrocytes
7) Confidence 0.45 Published 2009 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 19662385 Disease Relevance 0.07 Pain Relevance 0.56
The key findings are that nitric oxide is an important trigger for migraine, that 5-HT2B/5-HT2C receptors are present on endothelial cells and trigger nitric oxide release when activated and that supersensitivity of the 5-HT2B/5-HT2C receptor is a neurochemical feature predisposing to headache.
Positive_regulation (supersensitivity) of 5-HT2B in endothelial cells associated with migraine and headache
8) Confidence 0.21 Published 1994 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7824037 Disease Relevance 0.36 Pain Relevance 0.44
The increase in the NR1, NR2A, and NR2B receptor mRNAs started at 5 h, maintained for 1-7 days (P < 0.05-0.001) and returned to the control level at 14 days after inflammation.
Positive_regulation (increase) of NR2B receptor associated with inflammation
9) Confidence 0.00 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 11826044 Disease Relevance 0.80 Pain Relevance 0.84

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