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Context Info
Confidence 0.67
First Reported 1994
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.30
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR2C) nucleus (HTR2C) cytoplasm (HTR2C)
signal transducer activity (HTR2C)
Anatomy Link Frequency
endothelial cells 1
platelets 1
central nervous system 1
HTR2C (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 11 100.00 Very High Very High Very High
Migraine 11 99.24 Very High Very High Very High
headache 5 97.88 Very High Very High Very High
5HT 141 92.84 High High
Central nervous system 2 91.76 High High
agonist 15 91.72 High High
Neurotransmitter 4 88.64 High High
Pain 1 84.80 Quite High
Hyperalgesia 1 84.08 Quite High
Inflammatory response 1 79.20 Quite High
Disease Link Frequency Relevance Heat
Stress 1 99.82 Very High Very High Very High
Headache 16 99.24 Very High Very High Very High
Premature Ejaculation 79 89.48 High High
Anxiety Disorder 97 85.32 High High
Reprotox - General 1 9 85.04 High High
Pain 1 84.80 Quite High
Hyperalgesia 1 84.08 Quite High
Epilepsy 2 83.96 Quite High
Stress Incontinence 2 78.92 Quite High
Cognitive Disorder 4 68.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although activation of the 5-HT1a receptor exhibits proejaculatory effects, activation of the 5-HT1b and 5-HT2c receptors are involved in the process of delaying ejaculation.16,17 It has been hypothesized that altered levels of serotonin or serotonin receptor sensitivity in the ejaculatory modulating centers of the central nervous system are the pathophysiologic basis of ejaculatory disorders.17

Current treatments for PE

Positive_regulation (activation) of 5-HT2c in central nervous system associated with premature ejaculation, central nervous system and serotonin
1) Confidence 0.67 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695237 Disease Relevance 0.67 Pain Relevance 0.31
The key findings are that nitric oxide is an important trigger for migraine, that 5-HT2B/5-HT2C receptors are present on endothelial cells and trigger nitric oxide release when activated and that supersensitivity of the 5-HT2B/5-HT2C receptor is a neurochemical feature predisposing to headache.
Positive_regulation (supersensitivity) of 5-HT2C in endothelial cells associated with migraine and headache
2) Confidence 0.49 Published 1994 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7824037 Disease Relevance 0.36 Pain Relevance 0.44
Allelic variation in the serotonin 5-HT2C receptor gene and migraine.
Positive_regulation (variation) of 5-HT2C associated with migraine and serotonin
3) Confidence 0.49 Published 1997 Journal Neuroreport Section Title Doc Link 9295094 Disease Relevance 0.44 Pain Relevance 0.45
The actions of the drug are probably mostly due to activation of 5HT2C receptors because of its lower affinity to 5HT1A receptor subtype (Gross et al 1998; McDougle 1999).
Positive_regulation (activation) of 5HT2C
4) Confidence 0.45 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2416754 Disease Relevance 0.40 Pain Relevance 0.21
Endogenous 5-HT, arising perhaps from platelets but more likely from perivascular 5-HT-containing neurons in response to different types of "stress", would activate 5-HT2B/5-HT2C receptors on endothelial cells of the cerebral vasculature to release NO.
Positive_regulation (activate) of 5-HT2C in platelets associated with stress
5) Confidence 0.21 Published 1995 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 7639613 Disease Relevance 0.43 Pain Relevance 0.49

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