INT50669

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Context Info
Confidence 0.58
First Reported 1993
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 5.56
Pain Relevance 6.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ptn) endoplasmic reticulum (Ptn)
Anatomy Link Frequency
PTN 3
dorsal root ganglia 2
spinal cord 1
pore 1
ciliary 1
Ptn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Trigeminal neuralgia 8 100.00 Very High Very High Very High
qutenza 12 99.82 Very High Very High Very High
Neuropeptide 2 99.64 Very High Very High Very High
lidocaine 12 99.20 Very High Very High Very High
carbamazepine 3 98.88 Very High Very High Very High
Spinal cord 7 98.76 Very High Very High Very High
allodynia 3 98.52 Very High Very High Very High
Neuropathic pain 9 97.96 Very High Very High Very High
Eae 15 97.36 Very High Very High Very High
substance P 2 96.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Headache 8 100.00 Very High Very High Very High
Peptic Ulcer 1 99.16 Very High Very High Very High
Neuropathic Pain 12 98.52 Very High Very High Very High
Sprains And Strains 18 98.12 Very High Very High Very High
Injury 15 97.36 Very High Very High Very High
Nervous System Injury 6 97.04 Very High Very High Very High
Ganglion Cysts 1 96.88 Very High Very High Very High
Stress 3 94.00 High High
Hyperalgesia 4 90.64 High High
Anxiety Disorder 9 84.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, PTN was found to be downregulated in injured DRG of SD rats, the most sensitive strain in behavioural studies.
Negative_regulation (downregulated) of PTN in DRG associated with sprains and strains
1) Confidence 0.58 Published 2008 Journal Growth Factors Section Abstract Doc Link 18365878 Disease Relevance 1.35 Pain Relevance 0.66
The sequential trial has identified that Sanchaning could be used effectively to inhibit PTN and has the same effect as carbamazepine.
Negative_regulation (inhibit) of PTN associated with trigeminal neuralgia and carbamazepine
2) Confidence 0.58 Published 1995 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Abstract Doc Link 7640504 Disease Relevance 0.59 Pain Relevance 0.82
In contrast, receptors for ciliary neurotrophic factor and pleiotrophin were downregulated after avulsion.
Negative_regulation (downregulated) of pleiotrophin in ciliary
3) Confidence 0.57 Published 2009 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 19104442 Disease Relevance 0 Pain Relevance 0
The PTN can also be blocked proximally (7 cm) above the medial malleolus in the subfascial plane between the flexor hallucis longus and flexor digitorum longus tendons.
Negative_regulation (blocked) of PTN in medial
4) Confidence 0.50 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 17056973 Disease Relevance 0 Pain Relevance 0.07
We have tested this hypothesis by comparatively studying PTN and MK gene expression in the spinal cord and dorsal root ganglia (DRG) of three rat strains known to differ in their behavioural responses to chronic constriction injury (CCI) of the sciatic nerve: Lewis, Fischer 344 (F344) and Sprague-Dawley (SD).
Negative_regulation (studying) of PTN in dorsal root ganglia associated with eae, injury, sciatic nerve, sprains and strains and spinal cord
5) Confidence 0.43 Published 2008 Journal Growth Factors Section Abstract Doc Link 18365878 Disease Relevance 1.17 Pain Relevance 0.59
The P approach to PTN block may be a useful alternative to the traditional D site approach, particularly in patients with restricted access to the D site.


Negative_regulation (block) of PTN in PTN
6) Confidence 0.37 Published 2006 Journal Anesth. Analg. Section Body Doc Link 17056973 Disease Relevance 0 Pain Relevance 0
PTN block was considered successful if surgical anesthesia was achieved in all PTN distributions.
Negative_regulation (block) of PTN in PTN
7) Confidence 0.32 Published 2006 Journal Anesth. Analg. Section Body Doc Link 17056973 Disease Relevance 0 Pain Relevance 0
Thirteen of 78 PTN and L5 and S1 dermatomal SSEPs were abolished in the alkalinized lidocaine group compared to 4 of 78 SSEPs in the nonalkalinized group.
Negative_regulation (abolished) of PTN in PTN associated with lidocaine
8) Confidence 0.26 Published 1993 Journal Anesth. Analg. Section Abstract Doc Link 8424510 Disease Relevance 0 Pain Relevance 1.52
In contrast, substitution of the 2' pore-lining glycine by serine selectively reduces PTN sensitivity, whereas the introduction of 2' alanines selectively increases PTXININ sensitivity.
Negative_regulation (reduces) of PTN in pore
9) Confidence 0.16 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17714449 Disease Relevance 0 Pain Relevance 0.18
We have tested this hypothesis by comparatively studying PTN and MK gene expression in the spinal cord and dorsal root ganglia (DRG) of three rat strains known to differ in their behavioural responses to chronic constriction injury (CCI) of the sciatic nerve: Lewis, Fischer 344 (F344) and Sprague-Dawley (SD).
Negative_regulation (studying) of PTN in spinal cord associated with eae, injury, sciatic nerve, sprains and strains and spinal cord
10) Confidence 0.14 Published 2008 Journal Growth Factors Section Abstract Doc Link 18365878 Disease Relevance 1.17 Pain Relevance 0.59
This finding suggests that the main cause of the periods of reduced PTN activity is a decrease of the excitatory (most probably thalamic) drive.
Negative_regulation (reduced) of PTN
11) Confidence 0.14 Published 2007 Journal The European Journal of Neuroscience Section Body Doc Link PMC2777253 Disease Relevance 0 Pain Relevance 0.21
In the present study, we found that 24 h after electrolytic lesion of the rat MRN glandular gastric ulcers occurred, and the immune response to the mitogen concanavalin A was depressed.
Negative_regulation (depressed) of mitogen in MRN associated with peptic ulcer
12) Confidence 0.05 Published 1996 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 8728550 Disease Relevance 0.69 Pain Relevance 0.41
Capsaicin-induced inhibition of mitogen and interleukin-2-stimulated T cell proliferation: its reversal by in vivo substance P administration.
Negative_regulation (inhibition) of mitogen in T cell associated with qutenza and substance p
13) Confidence 0.03 Published 1996 Journal J. Neuroimmunol. Section Title Doc Link 8784269 Disease Relevance 0 Pain Relevance 0.64
Capsaicin treatment of neonatal rats (50 mg/kg at 2 days of age), results in a marked inhibition of mitogen and hrIL-2-induced cell proliferation both in the spleen and peripheral blood.
Negative_regulation (inhibition) of mitogen in blood associated with qutenza
14) Confidence 0.03 Published 1996 Journal J. Neuroimmunol. Section Abstract Doc Link 8784269 Disease Relevance 0 Pain Relevance 0.36
This was inhibited by a beta(2)-adrenergic receptor blocker and by an inhibitor of mitogen and extracellular signal-regulated kinase kinase (MEK), which phosphorylates and activates ERK1/2.
Negative_regulation (inhibitor) of mitogen
15) Confidence 0.02 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11517280 Disease Relevance 0.61 Pain Relevance 0.82

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