INT50670

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Context Info
Confidence 0.76
First Reported 1995
Last Reported 2010
Negated 21
Speculated 14
Reported most in Abstract
Documents 763
Total Number 781
Disease Relevance 442.13
Pain Relevance 195.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CPOX) small molecule metabolic process (CPOX) oxidoreductase activity (CPOX)
cytoplasm (CPOX)
Anatomy Link Frequency
macrophages 24
colon 20
SH-SY5Y 14
brain 13
kidney 12
CPOX (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 5782 100.00 Very High Very High Very High
COX-2 inhibitor 1814 100.00 Very High Very High Very High
COX2 378 100.00 Very High Very High Very High
cOX1 170 100.00 Very High Very High Very High
Sciatic nerve 144 100.00 Very High Very High Very High
cINOD 5052 99.98 Very High Very High Very High
Spinal cord 743 99.98 Very High Very High Very High
glial activation 69 99.90 Very High Very High Very High
Inflammatory mediators 206 99.88 Very High Very High Very High
Osteoarthritis 2423 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 7411 100.00 Very High Very High Very High
Cancer 5135 100.00 Very High Very High Very High
Disease 3423 100.00 Very High Very High Very High
Colon Cancer 690 100.00 Very High Very High Very High
Injury 637 100.00 Very High Very High Very High
Nervous System Injury 495 100.00 Very High Very High Very High
Breast Cancer 410 100.00 Very High Very High Very High
Stress 292 100.00 Very High Very High Very High
Alzheimer's Dementia 45 100.00 Very High Very High Very High
Repression 40 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Aceclofenac and 4'-hydroxyaceclofenac are the major compounds in human blood after the administration of aceclofenac, but they had no inhibitory effects on cyclooxygenase (COX) activity or COX expression in the rheumatoid synovial cells.
Gene_expression (expression) of COX in synovial cells
1) Confidence 0.76 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10215639 Disease Relevance 0.26 Pain Relevance 0.25
Aceclofenac and 4'-hydroxyaceclofenac are the major compounds in human blood after the administration of aceclofenac, but they had no inhibitory effects on cyclooxygenase (COX) activity or COX expression in the rheumatoid synovial cells.
Gene_expression (expression) of COX in synovial cells
2) Confidence 0.76 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10215639 Disease Relevance 0.26 Pain Relevance 0.25
COX-1 is constitutively expressed in most normal tissues; COX-2 is highly induced by proinflammatory mediators in the setting of inflammation, injury, and pain.
Gene_expression (expressed) of COX associated with pain, inflammation and injury
3) Confidence 0.71 Published 2010 Journal Vet. Pathol. Section Abstract Doc Link 20418470 Disease Relevance 0.45 Pain Relevance 0.35
This article focuses on the expression and function of COX enzymes in normal and pathologic conditions of the cardiovascular system and discusses the cardiovascular pathophysiologic complications associated with COX inhibition.
Gene_expression (expression) of COX in cardiovascular system
4) Confidence 0.71 Published 2010 Journal Vet. Pathol. Section Abstract Doc Link 20418470 Disease Relevance 0.36 Pain Relevance 0.30
These results suggest that redox status-dependent regulation of COX expression may mediate apoptosis induced by Cap in human neuroblastoma cells.
Gene_expression (expression) of COX associated with neuroblastoma, qutenza and apoptosis
5) Confidence 0.68 Published 2002 Journal J. Environ. Pathol. Toxicol. Oncol. Section Abstract Doc Link 12086397 Disease Relevance 0.89 Pain Relevance 0.78
Cap markedly suppressed the expression of COX-1 and COX-2.
Gene_expression (expression) of COX associated with qutenza
6) Confidence 0.68 Published 2002 Journal J. Environ. Pathol. Toxicol. Oncol. Section Abstract Doc Link 12086397 Disease Relevance 0.75 Pain Relevance 0.81
Cap markedly suppressed the expression of COX-1 and COX-2.
Gene_expression (expression) of COX associated with qutenza
7) Confidence 0.68 Published 2002 Journal J. Environ. Pathol. Toxicol. Oncol. Section Abstract Doc Link 12086397 Disease Relevance 0.75 Pain Relevance 0.82
METHODS: Surgical specimens from 44 patients with breast cancer who had undergone lumpectomy or mastectomy were analyzed by immunoblot analysis and immunohistochemical analysis to determine the expression profile of the constitutively expressed form of cyclooxygenase (COX-1) and the inducible form (COX-2); the specimens from 14 patients included normal breast tissue.
Gene_expression (expressed) of COX
8) Confidence 0.61 Published 1998 Journal J. Natl. Cancer Inst. Section Body Doc Link 9521170 Disease Relevance 0.09 Pain Relevance 0
METHODS: Surgical specimens from 44 patients with breast cancer who had undergone lumpectomy or mastectomy were analyzed by immunoblot analysis and immunohistochemical analysis to determine the expression profile of the constitutively expressed form of cyclooxygenase (COX-1) and the inducible form (COX-2); the specimens from 14 patients included normal breast tissue.
Spec (determine) Gene_expression (expression) of COX
9) Confidence 0.61 Published 1998 Journal J. Natl. Cancer Inst. Section Body Doc Link 9521170 Disease Relevance 0.09 Pain Relevance 0
Immunohistochemical staining of specimens that expressed COX-1 and/or COX-2 revealed that COX-1 was localized in stromal cells adjacent to the tumor but not in tumor cells.
Gene_expression (expressed) of COX in stromal cells
10) Confidence 0.61 Published 1998 Journal J. Natl. Cancer Inst. Section Body Doc Link 9521170 Disease Relevance 0.07 Pain Relevance 0
Immunohistochemical staining of specimens that expressed COX-1 and/or COX-2 revealed that COX-1 was localized in stromal cells adjacent to the tumor but not in tumor cells.
Gene_expression (expressed) of COX in stromal cells
11) Confidence 0.61 Published 1998 Journal J. Natl. Cancer Inst. Section Body Doc Link 9521170 Disease Relevance 0.07 Pain Relevance 0
NSAIDs are known to inhibit COX, suggesting that the beneficial effect of NSAIDs in colon cancer may be related to COX overexpression in this disease.
Gene_expression (overexpression) of COX in colon associated with colon cancer, cinod and disease
12) Confidence 0.61 Published 1998 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 9521170 Disease Relevance 0.88 Pain Relevance 0.42
CONCLUSION: Our results suggest that overexpression of COX may not be unique to colon cancer and may be a feature common to other epithelial tumors.


Gene_expression (overexpression) of COX in colon
13) Confidence 0.61 Published 1998 Journal J. Natl. Cancer Inst. Section Body Doc Link 9521170 Disease Relevance 0.06 Pain Relevance 0
Serum and the growth factors increased COX enzyme expression and mitogenesis, and decreased apoptosis as evaluated by the percentage of cells that were floating in culture media rather than attached.
Gene_expression (expression) of COX enzyme associated with apoptosis
14) Confidence 0.58 Published 2000 Journal Carcinogenesis Section Abstract Doc Link 10874020 Disease Relevance 0.91 Pain Relevance 0.18
The effect of the mitogens on COX enzyme expression was also evaluated.
Gene_expression (expression) of COX enzyme
15) Confidence 0.58 Published 2000 Journal Carcinogenesis Section Abstract Doc Link 10874020 Disease Relevance 0.89 Pain Relevance 0.18
The induction of cyclooxygenase-2 (COX-2) expression is associated with more aggressive gliomas and poor survival.
Gene_expression (expression) of COX associated with glioma
16) Confidence 0.56 Published 2005 Journal Exp. Cell Res. Section Abstract Doc Link 15561105 Disease Relevance 0.33 Pain Relevance 0.19
Among several NSAIDs tested, only sulindac sulfide and indomethacin suppressed laminin gamma1 protein expression, and this repression was observed in both COX-expressing and -deficient cell lines, suggesting that laminin gamma1 repression by COX inhibitors was independent of COX.
Gene_expression (expressing) of COX associated with repression and cinod
17) Confidence 0.56 Published 2005 Journal Exp. Cell Res. Section Abstract Doc Link 15561105 Disease Relevance 0.73 Pain Relevance 0.37
Increased expression of cyclooxygenase (COX) and overproduction of prostaglandins (PGs) have been implicated in the development and progression of colorectal cancer (CRC).
Gene_expression (expression) of COX associated with colon cancer
18) Confidence 0.55 Published 1998 Journal Cancer Res. Section Abstract Doc Link 9622066 Disease Relevance 0.42 Pain Relevance 0
Recent observations suggest that reactive oxygen intermediates play a role in tumor cell growth regulation and expression of the inducible COX, COX-2.
Gene_expression (expression) of COX associated with cancer
19) Confidence 0.55 Published 1998 Journal Cancer Res. Section Abstract Doc Link 9622066 Disease Relevance 0.52 Pain Relevance 0
In the present work, we characterize the protective effect of the indomethacin on the neurotoxicity elicited by amyloid-beta protein (A beta, fragments 25-35 and 1-42) alone or in combination with AA added exogenously as well as its effects on COX-2 expression.
Gene_expression (expression) of COX associated with drug induced neurotoxicity and alzheimer's dementia
20) Confidence 0.54 Published 2005 Journal Neurochem. Int. Section Abstract Doc Link 16169124 Disease Relevance 1.03 Pain Relevance 0.43

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