INT50672

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 1995
Last Reported 2010
Negated 15
Speculated 4
Reported most in Abstract
Documents 205
Total Number 209
Disease Relevance 125.93
Pain Relevance 60.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CPOX) small molecule metabolic process (CPOX) oxidoreductase activity (CPOX)
cytoplasm (CPOX)
Anatomy Link Frequency
macrophages 6
nerves 5
SH-SY5Y 4
fibroblasts 4
leg 4
CPOX (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1489 100.00 Very High Very High Very High
Osteoarthritis 749 100.00 Very High Very High Very High
metalloproteinase 389 100.00 Very High Very High Very High
COX-2 inhibitor 364 100.00 Very High Very High Very High
COX2 104 100.00 Very High Very High Very High
cOX1 47 100.00 Very High Very High Very High
cytokine 542 99.98 Very High Very High Very High
Spinal cord 336 99.80 Very High Very High Very High
cerebral cortex 10 99.80 Very High Very High Very High
antagonist 322 99.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1927 100.00 Very High Very High Very High
Osteoarthritis 796 100.00 Very High Very High Very High
Alzheimer's Dementia 14 100.00 Very High Very High Very High
Stress 83 99.98 Very High Very High Very High
Prostate Cancer 22 99.92 Very High Very High Very High
Endotoxemia 2 99.86 Very High Very High Very High
Cancer 916 99.84 Very High Very High Very High
Disease 699 99.84 Very High Very High Very High
Colon Cancer 184 99.84 Very High Very High Very High
Carcinoma 40 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, this article will discuss the evidence supporting the conclusion that the chemo-preventive activity of COX inhibitors is mediated, in part, by altered gene expression with an emphasis on NAG-1 studies.
Positive_regulation (mediated) of COX
1) Confidence 0.44 Published 2006 Journal Prog. Lipid Res. Section Abstract Doc Link 16337272 Disease Relevance 0.69 Pain Relevance 0.53
However, in situations where the release of protective PGs by COX-1 has been lost, the induction of COX-2 may compensate and reduce inflammatory responses.
Positive_regulation (induction) of COX associated with inflammatory response
2) Confidence 0.43 Published 1998 Journal Inflamm. Res. Section Abstract Doc Link 9831329 Disease Relevance 0.56 Pain Relevance 0.28
We, and others, have recently shown that COX-2 can be induced by proinflammatory cytokines in human blood vessels, and also in human airway cells.
Positive_regulation (induced) of COX in blood vessels associated with cytokine
3) Confidence 0.43 Published 1998 Journal Inflamm. Res. Section Abstract Doc Link 9831329 Disease Relevance 0.59 Pain Relevance 0.30
Recent observations suggest that reactive oxygen intermediates play a role in tumor cell growth regulation and expression of the inducible COX, COX-2.
Positive_regulation (inducible) of COX associated with cancer
4) Confidence 0.43 Published 1998 Journal Cancer Res. Section Abstract Doc Link 9622066 Disease Relevance 0.52 Pain Relevance 0
Recently, the identification of a cytokine-inducible isoform of COX, COX-2, has led to the suggestion that salicylate produces its anti-inflammatory actions by inhibiting COX-2 induction through actions on nuclear factor kappaB (NF-kappaB).
Positive_regulation (induction) of COX associated with inflammation and cytokine
5) Confidence 0.42 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9187256 Disease Relevance 0.42 Pain Relevance 0.45
A COX radioimmunoassay showed up-regulation of COX activity in chronic venous ulcers compared with normal skin (p<0.05).
Positive_regulation (up-regulation) of COX in skin associated with skin ulcer
6) Confidence 0.40 Published 2001 Journal J. Pathol. Section Abstract Doc Link 11745699 Disease Relevance 1.20 Pain Relevance 0.34
On the other hand, up-regulation of COX-2 is most likely responsible for the persistent inflammation in chronic venous leg ulcers.
Positive_regulation (up-regulation) of COX in leg associated with leg ulcer and inflammation
7) Confidence 0.40 Published 2001 Journal J. Pathol. Section Abstract Doc Link 11745699 Disease Relevance 1.05 Pain Relevance 0.31
Using immunoenzymatic labelling and western blot analysis, this study has shown that both COX-1 and COX-2 were up-regulated in chronic venous leg ulcers by comparison with normal human skin.
Positive_regulation (up-regulated) of COX in leg associated with leg ulcer
8) Confidence 0.40 Published 2001 Journal J. Pathol. Section Abstract Doc Link 11745699 Disease Relevance 0.84 Pain Relevance 0.27
Using immunoenzymatic labelling and western blot analysis, this study has shown that both COX-1 and COX-2 were up-regulated in chronic venous leg ulcers by comparison with normal human skin.
Positive_regulation (up-regulated) of COX in leg associated with leg ulcer
9) Confidence 0.40 Published 2001 Journal J. Pathol. Section Abstract Doc Link 11745699 Disease Relevance 0.84 Pain Relevance 0.28
Up-regulation of COX-1 in chronic venous leg ulcers could produce prostacyclin, which contributes to angiogenesis.
Positive_regulation (Up-regulation) of COX in leg associated with leg ulcer
10) Confidence 0.40 Published 2001 Journal J. Pathol. Section Abstract Doc Link 11745699 Disease Relevance 1.22 Pain Relevance 0.35
In particular, the inducible form of cyclooxygenase (COX), the rate-limiting enzyme in prostaglandin biosynthesis, is overexpressed in colon tumors.
Positive_regulation (inducible) of COX in colon associated with colon cancer
11) Confidence 0.39 Published 1998 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 9521170 Disease Relevance 0.85 Pain Relevance 0.36
Immunoblot analysis revealed extremely high levels of COX-2 protein in two tumor samples.
Positive_regulation (levels) of COX
12) Confidence 0.39 Published 1998 Journal J. Natl. Cancer Inst. Section Body Doc Link 9521170 Disease Relevance 0.08 Pain Relevance 0
COX-1 is constitutively expressed in most normal tissues; COX-2 is highly induced by proinflammatory mediators in the setting of inflammation, injury, and pain.
Positive_regulation (induced) of COX associated with pain, inflammation and injury
13) Confidence 0.37 Published 2010 Journal Vet. Pathol. Section Abstract Doc Link 20418470 Disease Relevance 0.46 Pain Relevance 0.36
Among several NSAIDs tested, only sulindac sulfide and indomethacin suppressed laminin gamma1 protein expression, and this repression was observed in both COX-expressing and -deficient cell lines, suggesting that laminin gamma1 repression by COX inhibitors was independent of COX.
Neg (independent) Positive_regulation (independent) of COX associated with repression and cinod
14) Confidence 0.36 Published 2005 Journal Exp. Cell Res. Section Abstract Doc Link 15561105 Disease Relevance 0.74 Pain Relevance 0.38
The inducible isoform, COX-2, is induced by pro-inflammatory stimuli in migratory cells and inflamed tissues.
Positive_regulation (induced) of COX associated with inflammatory stimuli
15) Confidence 0.36 Published 1998 Journal Int J Tissue React Section Abstract Doc Link 9561441 Disease Relevance 0.47 Pain Relevance 0.45
Recent observations suggest that reactive oxygen intermediates play a role in tumor cell growth regulation and expression of the inducible COX, COX-2.
Positive_regulation (inducible) of COX associated with cancer
16) Confidence 0.36 Published 1998 Journal Cancer Res. Section Abstract Doc Link 9622066 Disease Relevance 0.52 Pain Relevance 0
Classical NSAIDs like indomethacin inhibit both the constitutive COX-1 and the inducible COX-2 enzymes.
Positive_regulation (inducible) of COX associated with cinod
17) Confidence 0.35 Published 2005 Journal Neurochem. Int. Section Abstract Doc Link 16169124 Disease Relevance 0.88 Pain Relevance 0.48
While not detected in unstimulated normal mucosal cells and cancer cells, COX-2 protein was induced by both lipopolysaccharide (LPS) and LPC.
Positive_regulation (induced) of COX associated with cancer
18) Confidence 0.35 Published 1999 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 10328326 Disease Relevance 0.67 Pain Relevance 0.21
The COX enzyme family consists of the classical COX-1 enzyme, which is constitutively expressed in many tissues, and a second enzyme, i.e., COX-2, which is induced by various stimuli, such as mitogens and cytokines, and is involved in many inflammatory reactions.
Positive_regulation (induced) of COX associated with inflammation and cytokine
19) Confidence 0.34 Published 1998 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 9790545 Disease Relevance 0.54 Pain Relevance 0.26
We confirmed up-regulation of COX-2 in gastric cancer tissues compared with normal paired mucosa using Western blot analysis.
Positive_regulation (up-regulation) of COX associated with stomach cancer
20) Confidence 0.34 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10690533 Disease Relevance 1.01 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox