INT50673

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Context Info
Confidence 0.54
First Reported 1995
Last Reported 2010
Negated 5
Speculated 4
Reported most in Abstract
Documents 156
Total Number 162
Disease Relevance 97.31
Pain Relevance 37.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CPOX) small molecule metabolic process (CPOX) oxidoreductase activity (CPOX)
cytoplasm (CPOX)
Anatomy Link Frequency
colon 16
SH-SY5Y 10
macrophage 10
HASM 6
fibroblast 6
CPOX (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 751 100.00 Very High Very High Very High
Osteoarthritis 411 100.00 Very High Very High Very High
COX-2 inhibitor 267 100.00 Very High Very High Very High
Spinal cord 188 100.00 Very High Very High Very High
COX2 89 100.00 Very High Very High Very High
cytokine 200 99.98 Very High Very High Very High
Pain 358 99.84 Very High Very High Very High
Peripheral nerve injury 22 99.76 Very High Very High Very High
Inflammatory response 68 99.72 Very High Very High Very High
aspirin 126 99.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 878 100.00 Very High Very High Very High
Disease 450 100.00 Very High Very High Very High
Osteoarthritis 334 100.00 Very High Very High Very High
Phosphate Metabolism Disorders 220 100.00 Very High Very High Very High
Colon Cancer 136 100.00 Very High Very High Very High
Infection 54 100.00 Very High Very High Very High
Breast Cancer 42 100.00 Very High Very High Very High
Repression 10 100.00 Very High Very High Very High
Stomach Cancer 69 99.98 Very High Very High Very High
Cardiovascular Disease 8 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: Our results suggest that overexpression of COX may not be unique to colon cancer and may be a feature common to other epithelial tumors.


Positive_regulation (overexpression) of Gene_expression (overexpression) of COX in colon
1) Confidence 0.54 Published 1998 Journal J. Natl. Cancer Inst. Section Body Doc Link 9521170 Disease Relevance 0.06 Pain Relevance 0
NSAIDs are known to inhibit COX, suggesting that the beneficial effect of NSAIDs in colon cancer may be related to COX overexpression in this disease.
Positive_regulation (overexpression) of Gene_expression (overexpression) of COX in colon associated with colon cancer, cinod and disease
2) Confidence 0.54 Published 1998 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 9521170 Disease Relevance 0.88 Pain Relevance 0.42
Serum and the growth factors increased COX enzyme expression and mitogenesis, and decreased apoptosis as evaluated by the percentage of cells that were floating in culture media rather than attached.
Positive_regulation (increased) of Gene_expression (expression) of COX enzyme associated with apoptosis
3) Confidence 0.51 Published 2000 Journal Carcinogenesis Section Abstract Doc Link 10874020 Disease Relevance 0.91 Pain Relevance 0.18
Several studies have correlated an increase in the expression of COX-2 with a poor clinical outcome, while epidemiological studies demonstrate a reduced risk of cancer mortality in persons with longterm, chronic ingestion of non-steroidal anti-inflammatory drugs (NSAIDs).
Positive_regulation (increase) of Gene_expression (expression) of COX associated with inflammation, cancer and cinod
4) Confidence 0.46 Published 2003 Journal Expert Opin Emerg Drugs Section Abstract Doc Link 14610907 Disease Relevance 0.62 Pain Relevance 0.26
Since the COX-2 isoform was found to be overexpressed in a many human cancers, a particular attention was paid on the possible use of selective COX-2 inhibitors in cancer chemoprevention.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of COX associated with cancer and cox-2 inhibitor
5) Confidence 0.46 Published 2006 Journal Anti-cancer agents in medicinal chemistry Section Abstract Doc Link 16712451 Disease Relevance 0.64 Pain Relevance 0.23
COX-1 is constitutively expressed in most normal tissues; COX-2 is highly induced by proinflammatory mediators in the setting of inflammation, injury, and pain.
Positive_regulation (induced) of Gene_expression (expressed) of COX associated with pain, inflammation and injury
6) Confidence 0.43 Published 2010 Journal Vet. Pathol. Section Abstract Doc Link 20418470 Disease Relevance 0.46 Pain Relevance 0.36
In particular, the inducible form of cyclooxygenase (COX), the rate-limiting enzyme in prostaglandin biosynthesis, is overexpressed in colon tumors.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of COX in colon associated with colon cancer
7) Confidence 0.39 Published 1998 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 9521170 Disease Relevance 0.87 Pain Relevance 0.39
This possibility led us to ask whether COX is also overexpressed in breast cancers.
Spec (whether) Positive_regulation (overexpressed) of Gene_expression (overexpressed) of COX associated with breast cancer
8) Confidence 0.37 Published 1998 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 9521170 Disease Relevance 0.95 Pain Relevance 0.41
The induction of cyclooxygenase-2 (COX-2) expression is associated with more aggressive gliomas and poor survival.
Positive_regulation (induction) of Gene_expression (expression) of COX associated with glioma
9) Confidence 0.36 Published 2005 Journal Exp. Cell Res. Section Abstract Doc Link 15561105 Disease Relevance 0.33 Pain Relevance 0.19
Among several NSAIDs tested, only sulindac sulfide and indomethacin suppressed laminin gamma1 protein expression, and this repression was observed in both COX-expressing and -deficient cell lines, suggesting that laminin gamma1 repression by COX inhibitors was independent of COX.
Neg (independent) Positive_regulation (independent) of Gene_expression (repression) of COX associated with repression and cinod
10) Confidence 0.36 Published 2005 Journal Exp. Cell Res. Section Abstract Doc Link 15561105 Disease Relevance 0.74 Pain Relevance 0.38
Increased expression of cyclooxygenase (COX) and overproduction of prostaglandins (PGs) have been implicated in the development and progression of colorectal cancer (CRC).
Positive_regulation (Increased) of Gene_expression (expression) of COX associated with colon cancer
11) Confidence 0.36 Published 1998 Journal Cancer Res. Section Abstract Doc Link 9622066 Disease Relevance 0.42 Pain Relevance 0
Enhanced COX-2 expression was observed in colon cancer tissues from 15 subjects with clinically diagnosed colorectal cancer.
Positive_regulation (Enhanced) of Gene_expression (expression) of COX in colon associated with colon cancer
12) Confidence 0.36 Published 1995 Journal Cancer Res. Section Abstract Doc Link 7641194 Disease Relevance 1.09 Pain Relevance 0.34
These data suggest that the enhanced expression of the COX-2 gene in colon cancer tissues may contribute to the enhanced synthesis of prostaglandin E2 by the colon cancer tissues.
Positive_regulation (enhanced) of Gene_expression (expression) of COX in colon associated with colon cancer
13) Confidence 0.36 Published 1995 Journal Cancer Res. Section Abstract Doc Link 7641194 Disease Relevance 1.16 Pain Relevance 0.26
Enhanced expression of COX-2 may play a role in the pathogenesis of colon cancer.
Positive_regulation (Enhanced) of Gene_expression (expression) of COX in colon associated with colon cancer
14) Confidence 0.36 Published 1995 Journal Cancer Res. Section Abstract Doc Link 7641194 Disease Relevance 1.06 Pain Relevance 0.18
Since the COX-2 isoform was found to be overexpressed in a many human cancers, a particular attention was paid on the possible use of selective COX-2 inhibitors in cancer chemoprevention.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of COX associated with cancer and cox-2 inhibitor
15) Confidence 0.33 Published 2006 Journal Anti-cancer agents in medicinal chemistry Section Abstract Doc Link 16712451 Disease Relevance 0.65 Pain Relevance 0.23
COX-1 is ubiquitously and constitutively expressed in mammalian tissues and cells, whereas COX-2 is highly inducible and is generally present in mammalian tissues at very low levels, unless increased by one of many types of stimuli such as cytokines and growth factors.
Positive_regulation (increased) of Gene_expression (expressed) of COX associated with cytokine
16) Confidence 0.33 Published 2004 Journal Genome Biol Section Body Doc Link PMC522864 Disease Relevance 0.09 Pain Relevance 0.35
COX-1 is ubiquitously and constitutively expressed in mammalian tissues and cells, whereas COX-2 is highly inducible and is generally present in mammalian tissues at very low levels, unless increased by one of many types of stimuli such as cytokines and growth factors.
Positive_regulation (increased) of Gene_expression (expressed) of COX associated with cytokine
17) Confidence 0.33 Published 2004 Journal Genome Biol Section Body Doc Link PMC522864 Disease Relevance 0.08 Pain Relevance 0.35
COX-2, the inducible isoform of cyclooxygenase, is overexpressed in early and advanced CRC tissues, which portends a poor prognosis.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of COX
18) Confidence 0.32 Published 2005 Journal J. Clin. Oncol. Section Abstract Doc Link 15837998 Disease Relevance 0.44 Pain Relevance 0.27
Moreover, bupivacaine significantly increased COX-2 gene expression at 48 h as compared with the lidocaine/placebo group.
Positive_regulation (increased) of Gene_expression (expression) of COX
19) Confidence 0.30 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18165598 Disease Relevance 0.07 Pain Relevance 0
CONCLUSIONS: These results suggest that bupivacaine stimulates COX-2 gene expression after tissue injury, which is associated with higher PGE2 production and pain after the local anesthetic effect dissipates.


Positive_regulation (stimulates) of Gene_expression (expression) of COX in PGE2
20) Confidence 0.30 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18165598 Disease Relevance 0.05 Pain Relevance 0

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