INT50674

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Context Info
Confidence 0.78
First Reported 1993
Last Reported 2010
Negated 7
Speculated 14
Reported most in Abstract
Documents 459
Total Number 473
Disease Relevance 253.33
Pain Relevance 118.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (PTGS2) endoplasmic reticulum (PTGS2) enzyme binding (PTGS2)
protein complex (PTGS2) cytoplasm (PTGS2) lipid binding (PTGS2)
Anatomy Link Frequency
colon 13
macrophages 8
brain 7
PGE2 7
monocytes 6
PTGS2 (Homo sapiens)
PTGS2 - N580Q (1)
Pain Link Frequency Relevance Heat
Inflammation 1219 100.00 Very High Very High Very High
cINOD 1017 100.00 Very High Very High Very High
cytokine 593 100.00 Very High Very High Very High
COX2 515 100.00 Very High Very High Very High
aspirin 410 100.00 Very High Very High Very High
Pain 318 100.00 Very High Very High Very High
antagonist 122 100.00 Very High Very High Very High
cOX1 70 100.00 Very High Very High Very High
Analgesic 60 100.00 Very High Very High Very High
chemokine 59 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1816 100.00 Very High Very High Very High
Cancer 1606 100.00 Very High Very High Very High
Colon Cancer 448 100.00 Very High Very High Very High
Pain 335 100.00 Very High Very High Very High
Metastasis 193 100.00 Very High Very High Very High
Adenoma 110 100.00 Very High Very High Very High
Necrosis 89 100.00 Very High Very High Very High
Adhesions 63 100.00 Very High Very High Very High
Dysmenorrhea 40 100.00 Very High Very High Very High
Polyps 32 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although cyclooxygenase-2 is expressed in fetal kidneys, there are no reports of adverse effects in human pregnancy.
Gene_expression (expressed) of cyclooxygenase-2
1) Confidence 0.78 Published 2000 Journal Obstet Gynecol Section Abstract Doc Link 11094215 Disease Relevance 0.17 Pain Relevance 0.10
Excess eicosanoid formation during inflammation has been attributed to the expression of the gene coding for the inducible isoform of prostaglandin G/H synthase (PGHS-2).
Gene_expression (expression) of PGHS-2 associated with inflammation
2) Confidence 0.78 Published 1997 Journal Inflammopharmacology Section Abstract Doc Link 17694360 Disease Relevance 0.10 Pain Relevance 0.17
Recently, overexpression of cyclooxygenase-2 has been documented in colorectal tumors and numerous other pre-cancers and cancers.
Gene_expression (overexpression) of cyclooxygenase-2 associated with colorectal cancer and cancer
3) Confidence 0.78 Published 2002 Journal Cancer J Section Abstract Doc Link 12074318 Disease Relevance 1.04 Pain Relevance 0.28
Thus, the decrease we observe in overall PGSH-2 mRNA levels is likely to reflect both the known decline in numbers of neurons in AD as well as a lowered capacity for neuronal synthesis of PGHS-2, perhaps due to dysfunction or a loss of synaptic input.
Gene_expression (synthesis) of PGHS-2 in neurons associated with disease
4) Confidence 0.78 Published 1996 Journal Neurobiol. Aging Section Abstract Doc Link 8892355 Disease Relevance 0.72 Pain Relevance 0.07
To determine whether the increased prostaglandin production is due to enhanced expression of PHS-2 and whether the up-regulation of PHS-2 has any correlation to histopathological findings in brain tumors, we evaluated the profile of PHS expression in several human glioma cell lines and surgical specimens from patients with various types of brain tumors.
Gene_expression (expression) of PHS-2 in brain associated with glioma and brain tumor
5) Confidence 0.78 Published 2001 Journal Acta Neuropathol. Section Abstract Doc Link 11563634 Disease Relevance 1.03 Pain Relevance 0.18
Our data thus suggest that most brain tumors express PHS-2, which may also play a role in tumorigenesis in the brain.
Gene_expression (express) of PHS-2 in brain associated with brain tumor
6) Confidence 0.78 Published 2001 Journal Acta Neuropathol. Section Abstract Doc Link 11563634 Disease Relevance 1.96 Pain Relevance 0
In glioma cell lines, five out of six cell lines showed constitutive expression of PHS-2, whereas PHS-1 was weakly expressed in all of them.
Gene_expression (expression) of PHS-2 associated with glioma
7) Confidence 0.78 Published 2001 Journal Acta Neuropathol. Section Abstract Doc Link 11563634 Disease Relevance 1.85 Pain Relevance 0.15
All surgical specimens, except an ependymoma, which expressed both isozymes equally, expressed PHS-2 mRNA predominantly.
Gene_expression (expressed) of PHS-2 mRNA associated with ependymoma
8) Confidence 0.78 Published 2001 Journal Acta Neuropathol. Section Abstract Doc Link 11563634 Disease Relevance 2.21 Pain Relevance 0.14
Expression of prostaglandin H synthase-2 in human brain tumors.
Gene_expression (Expression) of prostaglandin H synthase-2 in brain associated with cox1 and brain tumor
9) Confidence 0.78 Published 2001 Journal Acta Neuropathol. Section Title Doc Link 11563634 Disease Relevance 1.36 Pain Relevance 0.29
Patients with cyclooxygenase-2 expression showed a significantly poorer outcome compared with those without cyclooxygenase-2 expression (P = 0.002).
Gene_expression (expression) of cyclooxygenase-2
10) Confidence 0.78 Published 2002 Journal Dis. Colon Rectum Section Body Doc Link 11786771 Disease Relevance 0.07 Pain Relevance 0
Multivariate analysis for factors associated with metachronous liver metastasis showed that cyclooxygenase-2 expression was one of the independent risk factors, second only to lymph node metastasis.
Gene_expression (expression) of cyclooxygenase-2 in lymph node
11) Confidence 0.78 Published 2002 Journal Dis. Colon Rectum Section Body Doc Link 11786771 Disease Relevance 0.07 Pain Relevance 0
The aim of this study was to clarify the clinicopathologic significance of cyclooxygenase-2 expression in human colorectal cancer.
Gene_expression (expression) of cyclooxygenase-2 associated with colon cancer
12) Confidence 0.78 Published 2002 Journal Dis. Colon Rectum Section Abstract Doc Link 11786771 Disease Relevance 0.53 Pain Relevance 0.08
In addition, several studies demonstrate increased expression of cyclooxygenase-2 in human colorectal cancer tissues.
Gene_expression (expression) of cyclooxygenase-2 associated with colon cancer
13) Confidence 0.78 Published 2002 Journal Dis. Colon Rectum Section Abstract Doc Link 11786771 Disease Relevance 0.46 Pain Relevance 0.09
CONCLUSION: Cyclooxygenase-2 expression in the primary lesion may be a useful marker for evaluating prognosis and liver metastasis in patients with colorectal cancer.


Gene_expression (expression) of Cyclooxygenase-2 in liver
14) Confidence 0.78 Published 2002 Journal Dis. Colon Rectum Section Body Doc Link 11786771 Disease Relevance 0.06 Pain Relevance 0
Cyclooxygenase-2 expression was noted in 71.6 percent (166/232) of the cancer patients and correlated significantly with histologic type (P = 0.033), depth of invasion (P = 0.016), pathologic stage (P = 0.020), and metachronous liver metastasis (P = 0.001).
Gene_expression (expression) of Cyclooxygenase-2 in liver
15) Confidence 0.78 Published 2002 Journal Dis. Colon Rectum Section Body Doc Link 11786771 Disease Relevance 0.08 Pain Relevance 0
However, the role of cyclooxygenase-2 expression in colorectal cancer has not yet been fully established.
Gene_expression (expression) of cyclooxygenase-2 associated with colon cancer
16) Confidence 0.78 Published 2002 Journal Dis. Colon Rectum Section Abstract Doc Link 11786771 Disease Relevance 0.46 Pain Relevance 0.09
Patients with cyclooxygenase-2 expression showed a significantly poorer outcome compared with those without cyclooxygenase-2 expression (P = 0.002).
Gene_expression (expression) of cyclooxygenase-2
17) Confidence 0.78 Published 2002 Journal Dis. Colon Rectum Section Body Doc Link 11786771 Disease Relevance 0.06 Pain Relevance 0
Cyclooxygenase-2 expression was then compared with clinicopathologic background and survival outcome.
Gene_expression (expression) of Cyclooxygenase-2
18) Confidence 0.78 Published 2002 Journal Dis. Colon Rectum Section Body Doc Link 11786771 Disease Relevance 0.09 Pain Relevance 0
RESULTS: Cyclooxygenase-2 was expressed in the cytoplasm of the cancer cells but not in normal epithelium.
Neg (not) Gene_expression (expressed) of Cyclooxygenase-2 in epithelium
19) Confidence 0.78 Published 2002 Journal Dis. Colon Rectum Section Body Doc Link 11786771 Disease Relevance 0.09 Pain Relevance 0
Cyclooxygenase-2 expression as a new marker for patients with colorectal cancer.
Gene_expression (expression) of Cyclooxygenase-2 associated with colon cancer and cox2
20) Confidence 0.78 Published 2002 Journal Dis. Colon Rectum Section Title Doc Link 11786771 Disease Relevance 0.46 Pain Relevance 0.15

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