INT50676

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Context Info
Confidence 0.07
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Title
Documents 2
Total Number 3
Disease Relevance 0.60
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGA4) plasma membrane (ITGA4)
Anatomy Link Frequency
neuron 1
ITGA4 (Homo sapiens)
Pain Link Frequency Relevance Heat
mu opioid receptor 2 99.12 Very High Very High Very High
lidocaine 5 98.80 Very High Very High Very High
sodium channel 3 96.88 Very High Very High Very High
Pain 5 96.12 Very High Very High Very High
antagonist 6 91.60 High High
Nav1.7 6 91.36 High High
Opioid 1 87.04 High High
Congenital analgesia 1 85.76 High High
nav1.8 3 83.28 Quite High
hyperexcitability 2 78.72 Quite High
Disease Link Frequency Relevance Heat
Pain 5 96.12 Very High Very High Very High
Syndrome 1 87.76 High High
Congenital Pain Insensitivity 1 85.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of ranolazine on wild-type and mutant hNav1.7 channels and on DRG neuron excitability.
Regulation (Effects) of wild-type in neuron
1) Confidence 0.07 Published 2010 Journal Mol Pain Section Title Doc Link 20529343 Disease Relevance 0.60 Pain Relevance 1.36
Modification of block by alterations in the alpha-subunit III-IV interdomain.
Regulation (alterations) of alpha-subunit III-IV
2) Confidence 0.00 Published 1995 Journal Circ. Res. Section Title Doc Link 7641328 Disease Relevance 0 Pain Relevance 0.43
In the present study, we have examined the effect of structural modifications on the affinity of norBNI analogues for wild-type and mutant kappa and mu opioid receptors expressed in COS-7 cells.
Spec (examined) Regulation (effect) of wild-type associated with mu opioid receptor
3) Confidence 0.00 Published 2000 Journal J. Med. Chem. Section Abstract Doc Link 10780914 Disease Relevance 0 Pain Relevance 0.34

General Comments

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