INT50687

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Context Info
Confidence 0.78
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.17
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Aldoc) mitochondrion (Aldoc) lyase activity (Aldoc)
aging (Aldoc) cytoplasm (Aldoc)
Anatomy Link Frequency
Purkinje cells 3
neuronal 2
neurons 1
Aldoc (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 6 90.80 High High
Pain 1 84.84 Quite High
member 8 4 78.08 Quite High
medulla 1 65.04 Quite High
Glutamate 8 64.72 Quite High
tetrodotoxin 4 63.92 Quite High
Hippocampus 2 27.44 Quite Low
depression 6 11.96 Low Low
gABA 18 7.60 Low Low
Dopamine 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 1 84.84 Quite High
Cognitive Disorder 6 82.16 Quite High
Apoptosis 8 44.80 Quite Low
Cerebellar Ataxia 37 25.24 Quite Low
Disease 26 22.28 Low Low
Starvation 46 14.20 Low Low
Autism 2 14.08 Low Low
Schizophrenia 2 12.56 Low Low
Depression 5 11.96 Low Low
Generalized Anxiety Disorder 2 8.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results are consistent with the concept that expression of the zebrin+ and zebrin- phenotypes is an intrinsic property of Purkinje cells.
Gene_expression (expression) of zebrin in Purkinje cells
1) Confidence 0.78 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 7642801 Disease Relevance 0 Pain Relevance 0.06
The fact that zebrin expression seems to depend on an intrinsic program of differentiation in Purkinje cells suggests some role for zebrin compartmentation in cerebellar function.
Gene_expression (expression) of zebrin in Purkinje cells
2) Confidence 0.78 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 7642801 Disease Relevance 0 Pain Relevance 0.06
These results are consistent with the concept that expression of the zebrin+ and zebrin- phenotypes is an intrinsic property of Purkinje cells.
Gene_expression (expression) of zebrin in Purkinje cells
3) Confidence 0.60 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 7642801 Disease Relevance 0 Pain Relevance 0.06
Genes involved in glycolysis are also enriched, including aldolase 3, C isoform (Aldoc), enolase 2 gamma neuronal (Eno2), malate dehydrogenase 1, NAD (soluble) (Mdh1) and oxoglutarate dehydrogenase (lipoamide) (Ogdh).
Gene_expression (enriched) of aldolase 3 in neuronal
4) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 0 Pain Relevance 0.20
Genes involved in glycolysis are also enriched, including aldolase 3, C isoform (Aldoc), enolase 2 gamma neuronal (Eno2), malate dehydrogenase 1, NAD (soluble) (Mdh1) and oxoglutarate dehydrogenase (lipoamide) (Ogdh).
Gene_expression (enriched) of Aldoc in neuronal
5) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 0 Pain Relevance 0.20
Zebrin II is expressed by a subset of Purkinje neurons forming parasagittal stripes which are highly reproducible between subjects and across species [156].
Gene_expression (expressed) of Zebrin II in neurons
6) Confidence 0.07 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866461 Disease Relevance 0.17 Pain Relevance 0.19

General Comments

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