INT50698

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Context Info
Confidence 0.52
First Reported 1995
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) extracellular region (Penk) aging (Jun)
nucleus (Jun) DNA binding (Jun) transcription factor binding (Jun)
Anatomy Link Frequency
striatum 2
Jun (Rattus norvegicus)
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 1 97.76 Very High Very High Very High
Hippocampus 4 85.72 High High
Nucleus accumbens 1 79.04 Quite High
Enkephalin 7 63.04 Quite High
adenocard 4 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have previously shown that in cell extracts from rat striatum, cyclic AMP response element (CRE) binding protein (CREB), rather than AP-1 proteins, preferentially interacts with the CRE-2 element of the proenkephalin second messenger-inducible enhancer, even under conditions in which AP-1 proteins are highly induced.
AP-1 Binding (interacts) of proenkephalin in striatum
1) Confidence 0.52 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7643080 Disease Relevance 0 Pain Relevance 0
In a complementary study we could not find increased binding to the AP-1-like site in the 5'-flanking sequence of proenkephalin following caffeine treatment.
AP-1 Binding (binding) of proenkephalin
2) Confidence 0.40 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7751931 Disease Relevance 0 Pain Relevance 0.10
We have previously shown that in cell extracts from rat striatum, cyclic AMP response element (CRE) binding protein (CREB), rather than AP-1 proteins, preferentially interacts with the CRE-2 element of the proenkephalin second messenger-inducible enhancer, even under conditions in which AP-1 proteins are highly induced.
AP-1 Binding (interacts) of proenkephalin in striatum
3) Confidence 0.39 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7643080 Disease Relevance 0 Pain Relevance 0
The blockade of KA-induced proENK and proDYN mRNA levels by the pre-treatment with L-ARG was well correlated with proto-oncoprotein levels, such as c-Fos, Fra-2, FosB, JunD, JunB, and c-Jun, as well as AP-1 and ENKCRE-2 DNA binding activities.
AP-1 Binding (activities) of proENK
4) Confidence 0.25 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.08
The blockade of KA-induced proENK and proDYN mRNA levels by the pre-treatment with L-ARG was well correlated with proto-oncoprotein levels, such as c-Fos, Fra-2, FosB, JunD, JunB, and c-Jun, as well as AP-1 and ENKCRE-2 DNA binding activities.
c-Jun Binding (activities) of proENK
5) Confidence 0.22 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.08
The combined treatment with FSK and PMA additively increased the proENK mRNA level, which was correlated with AP-1 or ENKCRE-2 DNA binding activity, and CREB phosphorylation.
AP-1 Binding (activity) of proENK mRNA
6) Confidence 0.15 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11113530 Disease Relevance 0 Pain Relevance 0.05

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