INT50704

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Context Info
Confidence 0.31
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 6.33
Pain Relevance 5.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Trib3) nucleus (Trib3) enzyme binding (Trib3)
kinase activity (Trib3)
Anatomy Link Frequency
skeletal muscle cells 2
spinal 1
neurons 1
brain 1
dorsal root ganglia 1
Trib3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 14 100.00 Very High Very High Very High
qutenza 7 99.68 Very High Very High Very High
Hyperalgesia 36 99.64 Very High Very High Very High
Central nervous system 29 98.76 Very High Very High Very High
intrathecal 53 98.54 Very High Very High Very High
nMDA receptor 29 98.20 Very High Very High Very High
Inflammation 102 97.28 Very High Very High Very High
Dorsal horn neuron 6 96.94 Very High Very High Very High
anesthesia 11 95.52 Very High Very High Very High
Dorsal horn 16 95.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 50 99.64 Very High Very High Very High
Apoptosis 60 99.48 Very High Very High Very High
Myocardial Reperfusion Injury 12 98.32 Very High Very High Very High
INFLAMMATION 98 97.28 Very High Very High Very High
Death 68 96.28 Very High Very High Very High
Poisoning 8 91.08 High High
Arthritis 69 89.36 High High
Ganglion Cysts 8 86.48 High High
Rheumatoid Arthritis 29 84.40 Quite High
Neuropathic Pain 21 84.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that lead inhibits creatine kinase and pyruvate kinase activity by interaction with their thiol groups.
kinase Binding (interaction) of
1) Confidence 0.31 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 19925858 Disease Relevance 0.19 Pain Relevance 0.09
We conclude that sevoflurane increases glucose uptake in skeletal muscle cells and that the sevoflurane-stimulated glucose uptake was associated with tyrosine kinase, protein kinase C, and intracellular Ca(2+).
kinase Binding (associated) of in skeletal muscle cells associated with kinase c
2) Confidence 0.19 Published 2002 Journal Anesth. Analg. Section Abstract Doc Link 12088955 Disease Relevance 0 Pain Relevance 0.43
We conclude that sevoflurane increases glucose uptake in skeletal muscle cells and that the sevoflurane-stimulated glucose uptake was associated with tyrosine kinase, protein kinase C, and intracellular Ca(2+).
kinase Binding (associated) of in skeletal muscle cells associated with kinase c
3) Confidence 0.19 Published 2002 Journal Anesth. Analg. Section Abstract Doc Link 12088955 Disease Relevance 0 Pain Relevance 0.43
Resiniferatoxin also caused direct activation of a Ca(2+)- and lipid-dependent kinase (or kinases) in the cytosolic fraction of dorsal root ganglia, at concentrations (100 nM to 10 microM) higher than required for displacement of [3H]resiniferatoxin binding or translocation of protein kinase C.
kinase Binding (binding) of in dorsal root ganglia associated with kinase c
4) Confidence 0.04 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7643108 Disease Relevance 0.17 Pain Relevance 0.74
PGE(2)-induced hyperalgesia is mediated by protein kinase A (PKA), while epinephrine-induced hyperalgesia is mediated by a combination of PKA, protein kinase Cepsilon (PKCepsilon) and mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK).
kinase Binding (combination) of associated with hyperalgesia
5) Confidence 0.03 Published 2005 Journal Pain Section Abstract Doc Link 15836982 Disease Relevance 0.93 Pain Relevance 0.80
PGE(2)-induced hyperalgesia is mediated by protein kinase A (PKA), while epinephrine-induced hyperalgesia is mediated by a combination of PKA, protein kinase Cepsilon (PKCepsilon) and mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK).
kinase Binding (combination) of associated with hyperalgesia
6) Confidence 0.03 Published 2005 Journal Pain Section Abstract Doc Link 15836982 Disease Relevance 0.94 Pain Relevance 0.81
The current study identifies an intracellular mechanism, to our knowledge not yet described, that involves spinal p38 MAP kinase as a link between the periphery and the CNS.
kinase Binding (link) of in spinal associated with central nervous system
7) Confidence 0.03 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1560929 Disease Relevance 0.47 Pain Relevance 0.69
Lastly, a DNA damage protein (Gadd45a) and a MAP kinase (Mapk14), two other proteins recently associated with Wnt activation, were also differentially expressed in PB- and PTU-treated animals but not in NaI-treated animals (Hildesheim et al. 2004).
kinase Binding (associated) of
8) Confidence 0.02 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1281279 Disease Relevance 0.40 Pain Relevance 0
However, reactive oxygen species (ROS) are formed in excessive amounts within the first few minutes following reperfusion and are considered important to myocardial reperfusion injury.5) In addition, excessive ROS during the early stages of reperfusion increases the activity of mitogen-activated protein (MAP) kinase and induces apoptosis following reperfusion.6-8)
kinase Binding (activity) of associated with myocardial reperfusion injury and apoptosis
9) Confidence 0.02 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2771824 Disease Relevance 1.38 Pain Relevance 0.08
We further delineated the participation of MAPK signal-interacting kinase (MNK), a novel substrate of ERK [20,21] in this process.
kinase Binding (interacting) of
10) Confidence 0.02 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.52 Pain Relevance 0.16
Our findings (Battaglia et al., 2003, and present work) support the idea of an activation by ephrinB2 of postsynaptic EphB receptors in neurons of the dorsal horn, since we showed that EphB1 receptors are present in dorsal horn neurons, where they are found in close association with NMDA receptors, and intrathecal administration of ephrinB2-Fc induces an increase in phosphorylated Src kinase associated with the EphB receptor itself.
kinase Binding (associated) of in neurons associated with nmda receptor, dorsal horn, dorsal horn neuron and intrathecal
11) Confidence 0.01 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 1.01 Pain Relevance 0.91
Rabbit muscle pyruvate kinase (this isoform is also present in the brain (Tsutsumi et al 1988; Yamada and Noguchi 1999)) did bind isatin and the Kd value of 10 ?
kinase Binding (bind) of in brain
12) Confidence 0.01 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721300 Disease Relevance 0 Pain Relevance 0.03
While binding to the kinase domain of JAK1 was not examined in that study, it has been suggested that therapeutic efficacy of CP-690,550 in some indications may be due to cross-over inhibition of other JAKs [23].
kinase Binding (binding) of
13) Confidence 0.00 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0.32 Pain Relevance 0.28

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