INT50706

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Context Info
Confidence 0.04
First Reported 1995
Last Reported 1995
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.28
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Phax, Trib3) nucleoplasm (Phax) nucleolus (Trib3)
RNA binding (Phax) enzyme binding (Trib3) kinase activity (Trib3)
Anatomy Link Frequency
dorsal root ganglion 4
Phax (Rattus norvegicus)
Trib3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 12 100.00 Very High Very High Very High
Kinase C 10 100.00 Very High Very High Very High
dorsal root ganglion 4 99.76 Very High Very High Very High
nociceptor 2 83.48 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 4 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Resiniferatoxin and capsaicin both caused translocation of protein kinase C in dorsal root ganglion neurones (EC50 value 18 +/- 3 nM).
Resiniferatoxin Positive_regulation (caused) of Localization (translocation) of kinase in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, kinase c and qutenza
1) Confidence 0.04 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7643108 Disease Relevance 0.10 Pain Relevance 0.65
These data imply that although resiniferatoxin-induced translocation of protein kinase C in dorsal root ganglion neurones was mainly indirect, it also caused direct activation of a protein kinase C-like kinase in these cells.
resiniferatoxin Positive_regulation (induced) of Localization (translocation) of kinase in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion and kinase c
2) Confidence 0.03 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7643108 Disease Relevance 0.18 Pain Relevance 0.73

General Comments

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