INT50712

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Context Info
Confidence 0.68
First Reported 1994
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 6.33
Pain Relevance 6.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Comt) plasma membrane (Comt) cytoplasm (Comt)
Anatomy Link Frequency
plasma 1
liver 1
brain 1
chromaffin cells 1
Comt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 202 100.00 Very High Very High Very High
Catecholamine 16 100.00 Very High Very High Very High
Pain 57 99.74 Very High Very High Very High
Dismenorea 2 99.52 Very High Very High Very High
opiate 1 99.08 Very High Very High Very High
drug abuse 7 98.92 Very High Very High Very High
endometriosis 2 98.88 Very High Very High Very High
Opioid 13 98.80 Very High Very High Very High
gABA 1 98.78 Very High Very High Very High
Migraine 1 97.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 58 99.74 Very High Very High Very High
Dysmenorrhea 2 99.52 Very High Very High Very High
Death 37 98.96 Very High Very High Very High
Drug Dependence 7 98.92 Very High Very High Very High
Endometriosis (extended) 2 98.88 Very High Very High Very High
Migraine Without Aura 1 98.32 Very High Very High Very High
Disease 133 97.40 Very High Very High Very High
Headache 3 95.52 Very High Very High Very High
Headache Disorders 3 92.24 High High
Alcohol Addiction 4 91.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genotyping of the COMT locus
Gene_expression (locus) of COMT associated with catechol-o-methyltransferase
1) Confidence 0.68 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1906749 Disease Relevance 2.10 Pain Relevance 0.11
Numerous SNPs have been detected in the COMT gene and 22 of the most frequent SNPs have been analysed regarding different aspects of pain and opioid responses [2,3,8,9], so the analyses of 11 SNPs in our study do not cover all genetic variation in the COMT gene.
Gene_expression (detected) of COMT associated with pain, catechol-o-methyltransferase and opioid
2) Confidence 0.60 Published 2008 Journal Mol Pain Section Body Doc Link PMC2644687 Disease Relevance 0.34 Pain Relevance 1.24
There are prospective
               negative studies, but they may have been under powered because of folate
               supplementation in the American and Canadian diet, leading to a milder increase in
               homocysteine than expected.44,53,54 Observational European non-prospective studies
               showed lower homocysteine levels in EN-treated patients.55–57

Homocysteine metabolism in relation to peripheral and central COMT inhibition

Neg (inhibition) Gene_expression (inhibition) of COMT associated with catechol-o-methyltransferase
3) Confidence 0.59 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778405 Disease Relevance 0.16 Pain Relevance 0.27
Therefore oxidative stress
               was found in combination with S-adenosylmethionine (SAM) depletion, as SAM is the
               methyl donor for nicotinamide N-methylation and most other important methylation
                   reactions.7,61,63–66 Accordingly, reduced SAM levels were found in
               chronic neurodegeneration.67–70
               LD/DDI further lowered SAM concentrations,71 as O-methylation of LD by COMT elevates homocysteine.58,64,72 Consequently, one may suggest combining central COMT inhibition with
               central blocking of monoaminooxidase-B. 
Neg (inhibition) Gene_expression (inhibition) of COMT associated with stress and catechol-o-methyltransferase
4) Confidence 0.59 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778405 Disease Relevance 0.22 Pain Relevance 0.40
Pheo contains large amount of enzyme catechol-O-methyl transpherase (COMT) with subsequent excessive production of COMT metabolites like metanephrines.
Gene_expression (production) of COMT
5) Confidence 0.55 Published 2009 Journal Cas. Lek. Cesk. Section Abstract Doc Link 19899721 Disease Relevance 0.49 Pain Relevance 0.13
The content of DA in blood and blood plasma, the characteristics of GABA and the opiate receptors of the brain, the activity of DBH, COMT, MAO, the content of cAMP and cGMP in brain tissue, as well as the expression of the gene c-fos were studied.
Gene_expression (expression) of COMT in brain associated with gaba and opiate
6) Confidence 0.53 Published 1994 Journal Neurosci. Behav. Physiol. Section Abstract Doc Link 7969881 Disease Relevance 0.25 Pain Relevance 0.19
We conclude that COMT polymorphisms on their own do not seem to play a relevant role as major genetic risk factors for MSD.
Gene_expression (polymorphisms) of COMT associated with catechol-o-methyltransferase
7) Confidence 0.52 Published 2010 Journal Genet Test Mol Biomarkers Section Abstract Doc Link 20373853 Disease Relevance 0.21 Pain Relevance 0.43
For assaying the in vitro O-methylation of L-DOPA by human liver cytosolic COMT, the incubation mixture usually consisted of 10 µM L-DOPA as substrate, 250 µM [3H-methyl]AdoMet (containing 0.2 µCi) as the methyl group donor, 0.25 mg/mL of human liver cytosolic protein as the source of COMT, 1 mM dithiothreitol, 1.2 mM MgCl2, and the dietary inhibitor (EGCG, GTP extract, or BTP extract) in a final volume of 0.25 mL Tris-HCl buffer (10 mM, pH 7.4).
Gene_expression (source) of COMT in liver
8) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916818 Disease Relevance 0.13 Pain Relevance 0.03
The data also suggest that common variants in OPRM1 and specific 'high pain sensitivity'COMT haplotypes may not be the cause of high opioid needs.
Gene_expression (haplotypes) of COMT associated with catechol-o-methyltransferase, pain and opioid
9) Confidence 0.17 Published 2009 Journal Eur J Pain Section Abstract Doc Link 19167252 Disease Relevance 1.05 Pain Relevance 1.88
No differences were found at the COMT and MAOA genes among the three groups investigated.
Neg (No) Gene_expression (found) of COMT
10) Confidence 0.07 Published 2006 Journal Eur. J. Neurol. Section Abstract Doc Link 16930369 Disease Relevance 1.04 Pain Relevance 0.90
BACKGROUND: The aim of the study was to test whether the COMT, CYP1A1 and CYP17 genes influence the risk of developing adenomyosis and endometriosis.
Gene_expression (influence) of COMT associated with endometriosis and dismenorea
11) Confidence 0.04 Published 2006 Journal Hum. Reprod. Section Abstract Doc Link 16527884 Disease Relevance 0.35 Pain Relevance 0.26
As adrenal medullary chromaffin cells express imidazoline binding sites in the absence of alpha 2-adrenergic receptors, these cells provide an ideal system in which to determine whether imidazolines can influence catecholamine gene expression through nonadrenergic receptors.
Gene_expression (expression) of catecholamine gene in chromaffin cells associated with catecholamine
12) Confidence 0.01 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7643129 Disease Relevance 0 Pain Relevance 0.34
This study examined the impact of a chronic physiological elevation of plasma cortisol levels on adrenal catecholamine synthetic enzyme and proenkephalin A mRNA expression in foetal sheep.
Gene_expression (expression) of catecholamine synthetic enzyme in plasma associated with catecholamine
13) Confidence 0.01 Published 1999 Journal J. Neuroendocrinol. Section Abstract Doc Link 10444314 Disease Relevance 0 Pain Relevance 0.05

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