INT50713

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Context Info
Confidence 0.69
First Reported 1995
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 1.50
Pain Relevance 4.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nisch) plasma membrane (Nisch) cytoplasm (Nisch)
Anatomy Link Frequency
plasma 2
medulla 1
chromaffin cells 1
Nisch (Rattus norvegicus)
Pain Link Frequency Relevance Heat
long-term potentiation 8 99.62 Very High Very High Very High
Morphine 19 99.52 Very High Very High Very High
Rostral ventrolateral medulla 10 99.42 Very High Very High Very High
antagonist 9 98.80 Very High Very High Very High
Cannabinoid 10 98.52 Very High Very High Very High
narcan 6 98.48 Very High Very High Very High
Nicotine 3 97.84 Very High Very High Very High
Clonidine 10 97.44 Very High Very High Very High
Opioid 5 96.12 Very High Very High Very High
Neurotransmitter 1 94.48 High High
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 3 99.74 Very High Very High Very High
Hypertension 4 99.28 Very High Very High Very High
Hypothermia 5 97.76 Very High Very High Very High
Diabetes Mellitus 7 97.48 Very High Very High Very High
Opiate Addiction 2 87.40 High High
Cv General 4 Under Development 3 75.00 Quite High
Substance Withdrawal Syndrome 1 48.04 Quite Low
Cv Unclassified Under Development 12 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that agmatine attenuated the effect of morphine on hippocampal LTP, possibly through activation of imidazoline receptor.
Spec (possibly) Positive_regulation (activation) of imidazoline receptor associated with long-term potentiation and morphine
1) Confidence 0.69 Published 2010 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 20451544 Disease Relevance 0 Pain Relevance 1.25
Activation of imidazoline receptor by agmatine to lower plasma glucose in streptozotocin-induced diabetic rats.
Positive_regulation (Activation) of imidazoline receptor in plasma associated with diabetes mellitus
2) Confidence 0.49 Published 2004 Journal Neurosci. Lett. Section Title Doc Link 15026161 Disease Relevance 0.50 Pain Relevance 0.10
Effect of ethanol on reductions in norepinephrine electrochemical signal in the rostral ventrolateral medulla and hypotension elicited by I1-receptor activation in spontaneously hypertensive rats.
Positive_regulation (activation) of I1-receptor in medulla associated with rostral ventrolateral medulla, pressure volume 2 under development and hypertension
3) Confidence 0.46 Published 2003 Journal Alcohol. Clin. Exp. Res. Section Title Doc Link 14506409 Disease Relevance 0.35 Pain Relevance 0.30
Idazoxan (2 mg/kg, i.p.), an imidazoline antagonist, blocked the enhancement by agmatine, thus suggesting that imidazoline receptor activation is required for agmatine to enhance cannabinoid-evoked hypothermia.
Positive_regulation (activation) of imidazoline receptor associated with hypothermia, cannabinoid and antagonist
4) Confidence 0.35 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17109846 Disease Relevance 0.33 Pain Relevance 0.62
After 1 hr of reperfusion serum NO concentration was elevated in IR1 and l-Arg(IR1) groups compared with group C but not in l-NAME(IR1) and Allo(IR1) group.
Neg (not) Positive_regulation (elevated) of IR1
5) Confidence 0.25 Published 2008 Journal Vascular Health and Risk Management Section Abstract Doc Link PMC2496980 Disease Relevance 0.14 Pain Relevance 0.07
Previous studies showed that an activation of imidazoline I2 receptor (I2R) in adrenal gland lowered plasma glucose through releasing beta-endorphin to stimulate the opioid-mu receptor in streptozotocin-induced diabetic rats (STZ rats).
Positive_regulation (activation) of imidazoline I2 receptor in plasma associated with diabetes mellitus and opioid
6) Confidence 0.25 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19822195 Disease Relevance 0.09 Pain Relevance 0.34
Although 100 microM clonidine diminishes nicotine-stimulated release of epinephrine and norepinephrine in chromaffin cells, this effect appears unrelated to stimulation of imidazoline receptor subtypes.
Spec (appears) Positive_regulation (stimulation) of imidazoline receptor in chromaffin cells associated with nicotine and clonidine
7) Confidence 0.06 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7643129 Disease Relevance 0 Pain Relevance 0.80
Modulation of agmatine on calcium signal in morphine-dependent CHO cells by activation of IRAS, a candidate for imidazoline I1 receptor.
Positive_regulation (activation) of imidazoline I1 receptor associated with narcan and morphine
8) Confidence 0.01 Published 2006 Journal Eur. J. Pharmacol. Section Title Doc Link 16962578 Disease Relevance 0.09 Pain Relevance 0.84

General Comments

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