INT50723

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Context Info
Confidence 0.53
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.47
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr4a2) DNA binding (Nr4a2) response to stress (Nr4a2)
cytoplasm (Nr4a2)
Anatomy Link Frequency
substantia nigra 2
ventral 2
brain 1
granulosa cell 1
Nr4a2 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 5 100.00 Very High Very High Very High
Substantia nigra 5 99.20 Very High Very High Very High
opioid receptor 5 99.20 Very High Very High Very High
antinociception 5 98.86 Very High Very High Very High
Ventral tegmentum 5 98.36 Very High Very High Very High
tail-flick 3 89.80 High High
Nucleus accumbens 10 89.68 High High
antagonist 4 87.24 High High
Dopamine 16 86.28 High High
midbrain 5 81.08 Quite High
Disease Link Frequency Relevance Heat
Psychosis 5 84.88 Quite High
Targeted Disruption 7 78.56 Quite High
Apoptosis 2 48.08 Quite Low
Adhesions 2 42.88 Quite Low
INFLAMMATION 1 24.80 Low Low
Fibrosarcoma 1 18.60 Low Low
Pain 1 14.96 Low Low
Repression 13 5.00 Very Low Very Low Very Low
Syndrome 6 5.00 Very Low Very Low Very Low
Premature Ovarian Failure 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to classical gene patterns induced in the striatal complex (striatum, accumbens) and cortex, most antipsychotic drugs tested strongly induced Nur77, Nor-1, and increased Nurr1 mRNA levels in the substantia nigra and ventral tegmental area.
Positive_regulation (increased) of Nurr1 in substantia nigra associated with ventral tegmentum and substantia nigra
1) Confidence 0.53 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15615863 Disease Relevance 0.08 Pain Relevance 0.30
The results are consistent with the previous study in mice [Tseng LF and Collins KA (1992) Eur J Pharmacol 214: 59-65] that the antinociception induced by beta-endorphin given i.t. is mediated by the stimulation of mu- and kappa-, but not delta- and epsilon-opioid receptors.
Positive_regulation (stimulation) of not associated with antinociception and opioid receptor
2) Confidence 0.49 Published 1995 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7643909 Disease Relevance 0 Pain Relevance 0.97
In addition to classical gene patterns induced in the striatal complex (striatum, accumbens) and cortex, most antipsychotic drugs tested strongly induced Nur77, Nor-1, and increased Nurr1 mRNA levels in the substantia nigra and ventral tegmental area.
Positive_regulation (induced) of Nurr1 in substantia nigra associated with ventral tegmentum and substantia nigra
3) Confidence 0.39 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15615863 Disease Relevance 0.08 Pain Relevance 0.30
Nr4a2 was found to be rapidly induced by cAMP in the KGN granulosa cell line [36].
Positive_regulation (induced) of Nr4a2 in granulosa cell
4) Confidence 0.37 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.08 Pain Relevance 0
Induction patterns of transcription factors of the nur family (nurr1, nur77, and nor-1) by typical and atypical antipsychotics in the mouse brain: implication for their mechanism of action.
Positive_regulation (Induction) of nurr1 in brain associated with enkephalin
5) Confidence 0.36 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 15615863 Disease Relevance 0.05 Pain Relevance 0.29
In addition to classical gene patterns induced in the striatal complex (striatum, accumbens) and cortex, most antipsychotic drugs tested strongly induced Nur77, Nor-1, and increased Nurr1 mRNA levels in the substantia nigra and ventral tegmental area.
Positive_regulation (increased) of Nurr1 in ventral associated with ventral tegmentum and substantia nigra
6) Confidence 0.18 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15615863 Disease Relevance 0.08 Pain Relevance 0.30
In addition to classical gene patterns induced in the striatal complex (striatum, accumbens) and cortex, most antipsychotic drugs tested strongly induced Nur77, Nor-1, and increased Nurr1 mRNA levels in the substantia nigra and ventral tegmental area.
Positive_regulation (induced) of Nurr1 in ventral associated with ventral tegmentum and substantia nigra
7) Confidence 0.13 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15615863 Disease Relevance 0.08 Pain Relevance 0.30

General Comments

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